Protein–Protein Interactions News and Research

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Study uncovers a protein-protein interaction that contributes to Parkinson's disease

In a study published in Nature Communications, a team led by Krembil Brain Institute Senior Scientists, Drs. Lorraine Kalia and Suneil Kalia, and University of Toronto (U of T) Professor, Dr. Philip M. Kim, identified a protein-protein interaction that contributes to Parkinson's disease.

20 Apr 2023

Study identifies four different autism subtypes based on brain activity and behavior

People with autism spectrum disorder can be classified into four distinct subtypes based on their brain activity and behavior, according to a study from Weill Cornell Medicine investigators.

7 Apr 2023

Highly complementary, biologically relevant protein-protein interactions can evolve entirely by chance

Proteins are the key players for virtually all molecular processes within the cell. To fulfil their diverse functions, they have to interact with other proteins.

7 Apr 2023

Researchers gain systematic insight into the organization of proteins in mitochondria

Mitochondria, the so-called powerhouse of the cells, are responsible for the energy supply of the organism and fulfill functions in metabolic and signaling processes.

25 Jan 2023

Novel machine learning method detects animal coronaviruses that might infect humans

Researchers used machine learning (ML) tools to discover animal coronaviruses (CoVs), both alpha and beta CoVs, previously unknown to infect humans.

15 Dec 2022

Researchers propose a deep antibody-antigen interaction algorithm to accelerate the identification of potential therapeutic antibodies

Researchers used a deep antibody-antigen interaction (DeepAAI) algorithm to understand the antibody representations of unseen antibodies to accelerate the discovery of novel antibodies with potential therapeutic applications.

9 Nov 2022

Study reveals conserved and divergent host responses to infections with SARS-CoV-2 variants of concern

Researchers analyzed the phenotypes of the SARS-CoV-2 variants of concern (VOCs), the molecular responses to infections from these VOCs, and the evolving virus-host interactions using a comparative genomic and proteomic approach.

26 Oct 2022

New research finds microclotting and inflammatory molecule abnormalities in long-COVID

A new study published on the preprint server medRxiv* determines how endothelial activation and inflammation contribute to the formation of microclots in PASC.

18 Oct 2022

Motif-based SARS-CoV-2 protein-human protein interactions as potential antiviral target sites

Researchers performed a ProP-PD (proteomic peptide phage display) analysis to identify peptides from intrinsically disordered human (host) proteome regions that bind with SARS-CoV-2 genome-encoded folded protein domains (PDs).

13 Oct 2022

Study offers a systems biology strategy to facilitate the search for effective COVID-19 drugs

A Cleveland Clinic-led research team used artificial intelligence to map out hundreds of ways that the virus that causes COVID-19 interacts with infected cells.

10 Oct 2022

The involvement of minor intron-containing gene-encoded proteins in viral infections

Researchers explored the role of the minor intron-containing gene (MIG)-encoded proteins (MIG-Ps) depending on minor spliceosome-MiG excision to be expressed in infections by pathogenic viruses.

6 Oct 2022

Small antiviral molecules termed assembly modulators show therapeutic efficacy against cancer

In a new study, researchers evaluated the anti-cancer therapeutic efficacy of two structurally-unrelated small molecules, PAV-617 and PAV-951.

4 Oct 2022

SARS-CoV-2 N escape mutations do not affect rapid antigen testing

A new study maps the escape mutations found in various strains of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that could cause them to escape neutralization by antibodies or detection by rapid antigen tests that rely on antibody binding for a positive result.

16 Sep 2022

Protein–Protein Interactions News and Research

Study uncovers a protein-protein interaction that contributes to Parkinson's disease

Study identifies four different autism subtypes based on brain activity and behavior

Highly complementary, biologically relevant protein-protein interactions can evolve entirely by chance

Researchers gain systematic insight into the organization of proteins in mitochondria

Novel machine learning method detects animal coronaviruses that might infect humans

Researchers propose a deep antibody-antigen interaction algorithm to accelerate the identification of potential therapeutic antibodies

Study reveals conserved and divergent host responses to infections with SARS-CoV-2 variants of concern

New research finds microclotting and inflammatory molecule abnormalities in long-COVID

Motif-based SARS-CoV-2 protein-human protein interactions as potential antiviral target sites

Study offers a systems biology strategy to facilitate the search for effective COVID-19 drugs

The involvement of minor intron-containing gene-encoded proteins in viral infections

Small antiviral molecules termed assembly modulators show therapeutic efficacy against cancer

SARS-CoV-2 N escape mutations do not affect rapid antigen testing

Researchers discover a new class of more potent and less toxic drugs for leukemia patients

The bat-virus relationship examined

New molecule kills a broad spectrum of hard-to-treat cancers

Association of neuronal and non-neuronal GABA with neuropsychiatric illness in COVID-19 patients

Sarbecovirus open reading frame 7a suppresses major histocompatibility complex-I antigen presentation

Study explores SARS-CoV-2 RNA genome's functional interactions with host cell

The diversity of transcriptional targets between four different coronavirus nsp1 proteins

Event guide: 4th Extra-Hepatic Lipid-Based Nanoparticles Delivery Summit eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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