RNA Interference News and Research

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Study sheds light on how SARS-CoV-2 virus switches between replication and packaging

Immediately after the infection of a cell in the throat or lungs, the SARS-CoV-2 virus works very hard to replicate, using the human cell's metabolic pathways to produce its proteins and make sure that its genetic material (the RNA genome) is copied.

21 Aug 2023

Newly discovered protein kinase shows promise for establishing future obesity and diabetes treatments

Researchers used genetically modified animal models to investigate the role of the newly discovered Traf2- and NCK-interacting protein kinase (TNIK) in obesity and metabolic dysfunction.

15 Aug 2023

Study discovers new mechanism for deadly tumor switch in prostate cancer

A study from the University of Michigan Rogel Cancer Center uncovers a new mechanism to explain why some prostate tumors switch from a common, treatable form to a more rare and aggressive form of prostate cancer.

14 Aug 2023

Scientists unravel step-by-step activation process of protein with deep evolutionary history

Scientists have unraveled the step-by-step activation process of a protein with a deep evolutionary history in all domains of life, opening the door to harnessing its functions for use as a biotechnology tool.

26 Jul 2023

New findings expand the genotypic spectrum of NPRL3-associated focal epilepsy

Science China Life Sciences magazine recently reported on the research results of Tang Beisha's team from Xiangya Hospital of Central South University, Liu Jing Yu's team from the Institute of Neurology of the Chinese Academy of Sciences, and Zhang Luoying's team from Huazhong University of Science and Technology, including Du Shiyue, Zeng Sheng, and Song Li. Epilepsy has a complex etiology with 80% owing a genetic basis.

15 Jun 2023

How do the outcomes of viral coinfections vary across host species?

In a recent study published in the journal PLOS Pathogens, researchers investigated the outcomes of coinfections of two viruses — Drosophila C Virus (DCV) and Cricket Paralysis Virus (CrPV) in 25 inbred lines of Drosophila melanogaster and 47 other host species belonging to the Drosophilidae family.

26 May 2023

New technology can deliver gene therapy directly to the lung

Scientists at UMass Chan Medical School have developed a technology to deliver gene therapy directly to lung tissue through intranasal administration, a development that could potentially create a new class of treatments for lung disease.

2 May 2023

Study shows SARS-CoV-2 causes DNA damage and elicits an altered DNA damage response

Researchers assessed the association between SARS-CoV-2 infection and DNA damage and cellular senescence.

14 Mar 2023

Study finds a new mammalian antiviral response pathway restricting poxviruses replication

In a recent study posted to the bioRxiv* preprint server, researchers identified a novel antiviral pathway different from the interferon (IFN) pathway that inhibited poxvirus(es) replication.

15 Feb 2023

Study identifies new tau regulators as viable therapeutic targets for Alzheimer's and other tauopathies

Neurodegenerative diseases affect millions of people worldwide and as our life expectancy increases, more individuals are expected to be affected in the coming decades.

16 Jan 2023

Bioinformatics approach for the design of siRNAs against SARS-CoV-2

Scientists have developed a set of siRNAs against SARS-CoV-2 using computational approaches.

14 Dec 2022

Research reveals a novel viral strategy in modulating stress granule formation to promote virus infection

Researchers illustrated a novel strategy likely employed by viruses to promote infection.

6 Dec 2022

SLU and industry partners report the first effective drug to treat rare, genetic liver disease

Researchers at Saint Louis University's School of Medicine, in collaboration with Arrowhead Pharmaceuticals and Takeda Pharmaceuticals, report the first effective drug to treat a rare, genetic liver disease that formerly could only be treated with a liver transplant.

26 Jul 2022

Lumasiran shows efficacy and acceptable safety in patients with PH1 and advanced kidney disease

In patients with PH1 and advanced kidney disease, including patients on hemodialysis, use of Lumasiran shows substantial reductions in plasma oxalate levels with acceptable safety.

14 Jul 2022

Researchers discover the first effective drug to treat rare, genetic liver disease

8 Jul 2022

Proteins in the eye may predict which macular degeneration patients need life-long treatment

In a study of eye fluid from 38 patients, Johns Hopkins Medicine researchers say they have found that levels of a specific protein appears to help accurately predict whether people with the wet form of age-related macular degeneration may need lifelong, frequent eye injections to preserve vision or if they can be safely weaned off the treatments.

29 Jun 2022

RNA Interference News and Research

Study sheds light on how SARS-CoV-2 virus switches between replication and packaging

Newly discovered protein kinase shows promise for establishing future obesity and diabetes treatments

Study discovers new mechanism for deadly tumor switch in prostate cancer

Scientists unravel step-by-step activation process of protein with deep evolutionary history

New findings expand the genotypic spectrum of NPRL3-associated focal epilepsy

How do the outcomes of viral coinfections vary across host species?

New technology can deliver gene therapy directly to the lung

Study shows SARS-CoV-2 causes DNA damage and elicits an altered DNA damage response

Study finds a new mammalian antiviral response pathway restricting poxviruses replication

Study identifies new tau regulators as viable therapeutic targets for Alzheimer's and other tauopathies

Bioinformatics approach for the design of siRNAs against SARS-CoV-2

Research reveals a novel viral strategy in modulating stress granule formation to promote virus infection

SLU and industry partners report the first effective drug to treat rare, genetic liver disease

Lumasiran shows efficacy and acceptable safety in patients with PH1 and advanced kidney disease

Researchers discover the first effective drug to treat rare, genetic liver disease

Proteins in the eye may predict which macular degeneration patients need life-long treatment

Researchers discover how a workhorse protein keeps protein production on track

The promise of RNA medicine is targeted and personalized

Probenecid shows activity against respiratory syncytial virus

RNA interference triggers that target SARS-CoV-2 genome

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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