Status Epilepticus News and Research

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Estrogen-inhibiting drug may suppress dangerous brain seizures

A class of drug that inhibits estrogen production and is used to treat breast cancer has been found to quickly and effectively suppress dangerous brain seizures, according to a new Northwestern University study.

13 May 2016

Penn researchers report results of CAR therapy trial in brain cancer patients

Immune cells engineered to seek out and attack a type of deadly brain cancer known as glioblastoma (GBM) were found to have an acceptable safety profile and successfully migrate to and infiltrate tumors, researchers from Penn Medicine and Harvard University reported at the AACR Annual Meeting 2016.

19 Apr 2016

Article provides specific nursing considerations related to caring for patients experiencing prolonged seizure

Time is of the essence when a patient experiences a prolonged seizure, and immediate action is required to prevent long-term neurological damage, according to an article in the April issue of Critical Care Nurse.

4 Apr 2016

Drexel University researchers explore effective drug for treating established status epilepticus

Drexel University College of Medicine researchers are conducting an emergency medicine study to find out the most effective drug for treating established status epilepticus -- a life-threatening condition in which the brain is in a state of persistent seizure.

14 Mar 2016

AES releases new guideline to help physicians treat status epilepticus patients effectively

Status epilepticus - continuous or rapid sequential seizure activity for 30 minutes or more - is a medical emergency with a high mortality rate in both children and adults. Prompt and effective treatment is key; therefore the American Epilepsy Society has released a new guideline to help physicians, hospitals, and health systems treat patients effectively.

10 Feb 2016

Common mortality causes prevail in epilepsy patients

A prospective, community-based study confirms that patients with epilepsy usually die of the same causes as other people.

19 Jan 2016

Early promise for cannabis extract treatment in epilepsy

A preliminary, open-label study suggests that cannabidiol may be a useful adjunctive treatment in adults and children with intractable epilepsy.

7 Jan 2016

Alexza reports interim results from AZ-002 Phase 2a study in epilepsy patients

Alexza Pharmaceuticals, Inc. today announced interim results of its Phase 2a study of AZ-002 (Staccato alprazolam) in epilepsy patients. AZ-002 produced a dose-related decrease in mean Standardized Photosensivity Range (SPR), the primary endpoint in the study.

21 Dec 2015

AES Annual Meeting takes our understanding of epilepsy to next level

Epilepsy remains one of the most common neurological conditions, affecting one in 26 Americans in their lifetime, with one-third having a form of the condition that resists treatment or effective management. With those statistics in mind, more than 5,200 neurologists, scientists, nurses and health professionals came to Philadelphia December 4-8 for the 2015 American Epilepsy Society Annual Meeting to discuss new discoveries and emerging technologies that can lead to more effective treatment.

18 Dec 2015

Prehospital combination therapy disappoints in status epilepticus

Adding levetiracetam to prehospital treatment with clonazepam does not improve control of generalised convulsive status epilepticus, shows a randomised phase III trial.

27 Nov 2015

Epilepsy common but variable in mitochondrial disease patients

Around a quarter of patients with mitochondrial diseases have seizures, but these do not appear to increase their risk of dying, report researchers.

27 Nov 2015

Misleading symptoms confuse management of older patients with post-HSE relapse

Research shows that teenagers and adults with immune-mediated relapse after herpes simplex encephalitis rarely display the symptoms typically seen in children, delaying the initiation of vital immunotherapy.

3 Nov 2015

Understanding the causes of sudden death in epilepsy: an interview with Professor Sanjay Sisodiya

SUDEP is the sudden unexpected witnessed or unwitnessed, non-traumatic and non-drowning death in people with epilepsy, with or without evidence of a seizure. It doesn’t necessarily have to be in the known context of a seizure, excluding documented status epilepticus, where people have seizure after seizure.

24 Aug 2015

Seizures are common but not clinically apparent in newborns after cardiac surgery

In 2011, the American Clinical Neurophysiology Society issued a guideline recommending that neonates undergoing cardiac surgery for repair of congenital heart disease be placed on continuous encephalographic (EEG) monitoring after surgery to detect seizures. These recommendations followed reports that seizures are common in this population, may not be detected clinically, and are associated with adverse neurocognitive outcomes.

20 Aug 2015

Antiepileptic monotherapy does not increase intrauterine death risk

Neither type nor dosage of antiepileptic drug affects the risk of intrauterine death among pregnant women with epilepsy when given as monotherapy, suggests research.

4 Aug 2015

Clonazepam study supports European practice in status epilepticus

A study comparing outcomes among patients treated with first-line lorazepam, midazolam or clonazepam for status epilepticus finds that the three drugs are broadly equivalent.

22 Jun 2015

Finding may pave way for much-needed treatments for people with epilepsy

An amino acid whose role in the body has been all but a mystery appears to act as a potent seizure inhibitor in mice, according to a study by researchers at Johns Hopkins.

22 Jun 2015

Midazolam drug helps recover full consciousness in traumatic brain injury patient

A patient who had suffered a traumatic brain injury unexpectedly recovered full consciousness after the administration of midazolam, a mild depressant drug of the GABA A agonists family.

14 Dec 2014

New, easy-to-use EEG electrode can measure brain function abnormalities

A new, easy-to-use EEG electrode set for the measurement of the electrical activity of the brain was developed in a recent study completed at the University of Eastern Finland. The solutions developed in the PhD study of Pasi Lepola, MSc, make it possible to attach the electrode set on the patient quickly, resulting in reliable results without any special treatment of the skin.

24 Sep 2014

Stereotactic radiosurgery feasible for multiple brain metastases

Stereotactic radiosurgery is a feasible treatment option for cancer patients with up to 10 brain metastases, Japanese researchers report in The Lancet Oncology.

28 Aug 2014