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Critical receptor in liver regeneration identified

In studies in mouse models, researchers at the University of California, San Diego (UCSD) School of Medicine have found that a cellular receptor involved in triggering cell death is also a necessary component of tissue repair and regeneration immediately following liver injury.

2 Apr 2007

Revving up a crucial set of muscle genes improves muscular dystrophy symptoms in mice

Scientists at Dana-Farber Cancer Institute have shown in a laboratory study that revving up a crucial set of muscle genes counteracts the damage caused by a form of muscular dystrophy.

2 Apr 2007

Possible therapeutic target for Duchenne muscular dystrophy

In the April 1st issue of Genes & Development, Dr. Bruce Spiegelman (Dana Farber Cancer Institute) and colleagues identify a key genetic component of and possible therapeutic target for Duchenne muscular dystrophy.

2 Apr 2007

Researchers identify gene for osteoporosis

Researchers report the identification of a gene that may play a role in susceptibility to osteoporosis, the crippling disease that leads to bone fractures, especially of the hip and spine.

31 Mar 2007

Brain's immune system plays protective role in early Alzheimer's disease

The immune system's response against amyloid-beta, the protein that forms plaques in the brains of patients with Alzheimer's disease, appears to protect the brain from damage in early stages of the devastating neurological disorder.

30 Mar 2007

Researchers look at whether creatine slows progression of Parkinson's disease

Researchers at the University of Rochester Medical Center are leading one of the largest clinical trials ever for Parkinson's disease.

25 Mar 2007

Circadian genes may be involved in bipolar disorder

Disrupt the gene that regulates the biological clocks in mice and they become manic, exhibiting behaviors similar to humans with bipolar disorder, UT Southwestern Medical Center researchers have found.

25 Mar 2007

Inflammation plays key role in the metastasis of prostate cancer

Many would assume that "mounting an immune response" or "having your body fight the cancer" is a good thing.

19 Mar 2007

Scientists decipher a signaling pathway crucially involved in Crohn's disease and ulcerative colitis

Inflammatory bowel diseases, such as Crohn's disease and Ulcerative Colitis, severely impair the lives of more than four million people worldwide. The development of effective therapies against these diseases requires an understanding of their underlying molecular mechanisms.

15 Mar 2007

Researchers use poliovirus to destroy neuroblastoma tumors in mice

The cause of one notorious childhood disease, poliovirus, could be used to treat the ongoing threat of another childhood disease, neuroblastoma.

15 Mar 2007

Researchers uncover genetic sequence responsible for rare form of pancreatic cancer

Pancreatic ductal adenocarcinoma is an almost uniformly fatal disease regardless of the stage at time of diagnosis. However, a small percentage of patients develop a form of ductal adenocarcinoma associated with cystic lesions that can be detected earlier, is less aggressive and has a 50 percent long-term survival rate.

14 Mar 2007

Interferon gamma identified as one of the signaling proteins involved with tumor relapse

Researchers at Virginia Commonwealth University's Massey Cancer Center studying the interaction between the immune system and cancer cells have identified interferon gamma as one of the signaling proteins involved with tumor relapse.

13 Mar 2007

Islet cell trasnplant without immunosuppressive drugs successful in mice

Scientists at Weill Cornell Medical College may have reached a breakthrough in the search for a lasting cure for type 1 diabetes.

11 Mar 2007

Inhaled Celecoxib shows new promise for lung cancer treatment

In recent years, Cycloxygenase (COX)-2 has emerged as a therapeutic target for the prevention and treatment of various types of cancers.

6 Mar 2007

Green tea and COX-2 inhibitors combine to slow growth of prostate cancer

Drinking a nice warm cup of green tea has long been touted for its healthful benefits, both real and anecdotal. But now researchers have found that a component of green tea, combined with low doses of a COX-2 inhibitor, could slow the spread of human prostate cancer.

1 Mar 2007

Metabolic response to colitis varies depending upon whether inflammation is chronic or acute

A new study being published by the American Physiological Society finds that the body responds differently to colitis (inflammation of the colon) based on whether the disease is acute (sharp and brief) or chronic (long-term).

27 Feb 2007

Genetically caused deafness may be reversible by compensating for a missing protein

Emory University researchers have found that in mice, increasing the amount of the protein connexin26 in the ear's cochlea compensates for an absence of another protein, connexin30.

26 Feb 2007

Old drug pentylenetetrazole may improve learning and memory in Down syndrome victims

Researchers in the United States have discovered that an old drug once used to study epilepsy substantially improved learning and memory in mice with Down syndrome symptoms.

26 Feb 2007

Mechanism driving iron overload in thalassemia identified

Led by researchers at Weill Cornell Medical College in New York City, an international group of scientists has pinpointed a specific genetic relationship as the cause of dangerous iron overload in persons with a form of the inherited blood disease, beta-thalassemia.

14 Feb 2007

Dipeptidyl peptidase I critical for early growth of abdominal aortic aneurysms

Surgery is the only treatment for an abdominal aortic aneurysm, a weak spot in the body's main artery that dilates dangerously over time.

13 Feb 2007

Mouse Model News and Research

Critical receptor in liver regeneration identified

Revving up a crucial set of muscle genes improves muscular dystrophy symptoms in mice

Possible therapeutic target for Duchenne muscular dystrophy

Researchers identify gene for osteoporosis

Brain's immune system plays protective role in early Alzheimer's disease

Researchers look at whether creatine slows progression of Parkinson's disease

Circadian genes may be involved in bipolar disorder

Inflammation plays key role in the metastasis of prostate cancer

Scientists decipher a signaling pathway crucially involved in Crohn's disease and ulcerative colitis

Researchers use poliovirus to destroy neuroblastoma tumors in mice

Researchers uncover genetic sequence responsible for rare form of pancreatic cancer

Interferon gamma identified as one of the signaling proteins involved with tumor relapse

Islet cell trasnplant without immunosuppressive drugs successful in mice

Inhaled Celecoxib shows new promise for lung cancer treatment

Green tea and COX-2 inhibitors combine to slow growth of prostate cancer

Metabolic response to colitis varies depending upon whether inflammation is chronic or acute

Genetically caused deafness may be reversible by compensating for a missing protein

Old drug pentylenetetrazole may improve learning and memory in Down syndrome victims

Mechanism driving iron overload in thalassemia identified

Dipeptidyl peptidase I critical for early growth of abdominal aortic aneurysms

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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