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Nanoparticle boost for antitumor vaccines

Researchers have known for some time that certain sequences of synthetic DNA induce potent immune responses when injected into animals and humans.

12 Feb 2007

A plasminogen-activating protease specifically controls the development of primary pneumonic plague

The deadly attack of the bacterium that causes pneumonic plague is significantly slowed when it can't make use of a key protein, scientists at Washington University School of Medicine in St. Louis report in Science.

28 Jan 2007

TrkB and its role in learning and memory

For the first time researchers investigate the molecular basis of memory in living mice.

9 Jan 2007

Scientists spot mechanism behind promising new sleep drug

An experimental drug called gaboxadol may soon help millions of bleary-eyed insomniacs get to sleep, and a multi-center team of U.S. scientists believes they've pinpointed just how the drug works.

1 Nov 2006

Effective test for screening Huntington's disease drugs

A test using cultured cells provides an effective way to screen drugs against Huntington's disease and shows that two compounds - memantine and riluzole - are most effective at keeping cells alive under conditions that mimic the disorder, UT Southwestern Medical Center researchers report.

30 Oct 2006

Scientists discover how brain turns on system designed to protect nerve cells from toxic "free radicals"

Scientists at Dana-Farber Cancer Institute report they have found how the brain turns on a system designed to protect its nerve cells from toxic "free radicals," a waste product of cell metabolism that has been implicated in some degenerative brain diseases, heart attacks, strokes, cancer, and aging.

20 Oct 2006

Gene mutation explains type of brittle bone disease

A newly identified gene mutation helps explain a subset of cases of osteogenesis imperfecta (OI), or brittle bone disease, whose origin had until now remained mysterious.

20 Oct 2006

Heme oxygenase-1 protects against lung damage in silicosis

Levels of heme oxygenase-1 (HO-1), an antioxidant that protects against reactive oxygen species (damaging oxygen molecules that cause direct tissue injury), become elevated in the lungs of chronic silicosis patients and could represent a new treatment approach for the disease.

16 Oct 2006

Cabernet Sauvignon may reduce incidence of Alzheimer's Disease

A new study directed by Mount Sinai School of Medicine has found that moderate red wine consumption in a form of Cabernet Sauvignon may help reduce the incidence of Alzheimer's Disease (AD).

20 Sep 2006

Carbon monoxide shown to reverse symptoms of pulmonary hypertension

In a medical case of Jekyll and Hyde, carbon monoxide - the highly toxic gas emitted from auto exhausts and faulty heating systems - has proven effective in treating the symptoms of pulmonary arterial hypertension (PAH), an extremely debilitating condition that typically leads to right heart failure and eventual death.

20 Sep 2006

Nicotinamide may help people with multiple sclerosis

Researchers have found a possible way to protect people with multiple sclerosis (MS) from severe long-term disability: increase nervous-system levels of a vital compound, called nicotinamide adenine dinucleotide (NAD), by giving its chemical precursor - nicotinamide, a form of vitamin B3.

19 Sep 2006

Researchers identify how molecules of microRNA are responsible for the growth of blood vessels in a model for human colon cancer

The process, called angiogenesis, results in ability of ravenous cancer cells to recruit blood vessels and receive a steady supply of nutrients and oxygen.

4 Aug 2006

Mouse Model News and Research

Nanoparticle boost for antitumor vaccines

A plasminogen-activating protease specifically controls the development of primary pneumonic plague

TrkB and its role in learning and memory

Scientists spot mechanism behind promising new sleep drug

Effective test for screening Huntington's disease drugs

Scientists discover how brain turns on system designed to protect nerve cells from toxic "free radicals"

Gene mutation explains type of brittle bone disease

Heme oxygenase-1 protects against lung damage in silicosis

Cabernet Sauvignon may reduce incidence of Alzheimer's Disease

Carbon monoxide shown to reverse symptoms of pulmonary hypertension

Nicotinamide may help people with multiple sclerosis

New class of super NSAIDs

Useful insights into mechanisms of catecholaminergic polymorphic ventricular tachycardia

First treatment for Hunter disease

New findings support Rapamycin's role as cancer treatment

Enrichment of regulatory CD4+CD25+ T cells by inhibition of phospholipase D signaling

Gene amplification links growth controlling pathway from Drosophila to human cancers

For the first time, scientists watch neurons change in response to experience

New way of delivering corrective genes holds promise for hereditary diseases of the heart

Researchers identify how molecules of microRNA are responsible for the growth of blood vessels in a model for human colon cancer

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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