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New CAR T-cell immunotherapy trial targets solid tumors

Seattle Children's has opened a chimeric antigen receptor (CAR) T-cell immunotherapy trial for children and young adults with relapsed or refractory non-central nervous system EGFR-expressing solid tumors. In the phase 1 trial, STRIvE-01, cancer-fighting CAR T cells will target the EGFR protein expressed in many childhood sarcoma, kidney and neuroblastoma tumors.

7 Aug 2018

Study could help explain why Asians often develop diabetes at a lower body weight

A new UC San Francisco study has discovered a key biological difference in how people of European and Chinese descent put on weight -- a finding that could help explain why Asians often develop type 2 diabetes at a much lower body weight than Caucasians.

7 Aug 2018

Young children are more vulnerable to climate-related health risks, shows study

Young children are far more vulnerable to climate-related disasters and the onus is on adults to provide the protection and care that children need, according to research by Columbia University's Mailman School of Public Health and Columbia University Irving Medical Center.

7 Aug 2018

Medicaid expansion increases access to diabetes treatment

Prescriptions for diabetes medications increased in the first two years after states expanded eligibility for Medicaid as part of the Affordable Care Act, compared to states that didn't expand Medicaid.

7 Aug 2018

Rutgers researchers receive $2.5 million NIEHS grant to study cadmium exposure in expecting mothers

Rutgers researchers, with the aid of $2.5 million National Institute of Environmental Health Sciences grant, will study how exposure to cadmium during pregnancy can impact fetal development.

7 Aug 2018

Red blood cells contribute to cardiovascular diseases in patients with type 2 diabetes

Harmful effects of substances secreted from red blood cells could explain the increased risk of cardiovascular diseases in patients with type 2 diabetes, the results of two new studies conducted at Karolinska Institutet in Sweden indicate.

6 Aug 2018

Probiotic use could result in disorienting brain fogginess and rapid belly bloating

Probiotic use can result in a significant accumulation of bacteria in the small intestine that can result in disorienting brain fogginess as well as rapid, significant belly bloating, investigators report.

6 Aug 2018

Study improves understanding of preeclampsia heart damage in pregnancy

Johns Hopkins researchers say a heart imaging study of scores of pregnant women with the most severe and dangerous form of a blood pressure disorder has added to evidence that the condition - known as preeclampsia - mainly damages the heart's ability to relax between contractions, making the organ overworked and poor at pumping blood.

6 Aug 2018

Research: Having large muscle size could 'outweigh' poor muscle quality in CKD patients

The size of muscles in patients suffering from Chronic Kidney Disease could be more important to maintaining good physical performance than muscle quality, new research has shown.

6 Aug 2018

Scientists map regulatory landscape of mouse genome at single-cell resolution

Scientists have completed a major effort to map the regulatory landscape of the mouse genome at a single-cell resolution.

2 Aug 2018

Otsuka’s JINARC approved for treatment of patients with CKD stage 4 ADPKD

Otsuka Pharmaceutical Europe Ltd. today announced that the European Commission has approved an extension of indication for JINARC to include adult patients with CKD stage 4 Autosomal Dominant Polycystic Kidney Disease

2 Aug 2018

Researchers uncover new mechanisms underlying common kidney cancer in children

Connecting two previously unrelated insights about the formation of pediatric kidney cancer, researchers at UT Southwestern Medical Center have uncovered the means by which the cancer continues to grow, providing potential targets for more effective treatments in the future.

2 Aug 2018

Blood samples used to understand repair and regeneration mechanisms of transplanted organs

Researchers at Wake Forest Baptist Medical Center have shown that gene expression analysis of blood samples taken from the recipients of transplanted kidneys can be used to better understand the mechanisms that promote repair and regeneration of the transplanted organs.

1 Aug 2018

Gene linked to hair loss could be exploited to improve cancer immunotherapy

A gene that's associated with an autoimmune form of hair loss could be exploited to improve cancer immunotherapy, suggests a new mouse study by Columbia University Irving Medical Center (CUIMC) researchers.

31 Jul 2018

FDA approves first therapy for patients with rare tumors of the adrenal gland

The U.S. Food and Drug Administration today approved Azedra (iobenguane I 131) injection for intravenous use for the treatment of adults and adolescents age 12 and older with rare tumors of the adrenal gland (pheochromocytoma or paraganglioma) that cannot be surgically removed (unresectable), have spread beyond the original tumor site and require systemic anticancer therapy.

31 Jul 2018

New improved mouse model could revolutionize bone metastasis research

Researchers at Tokyo Institute of Technology propose an improved mouse model that could revolutionize bone metastasis research. Their method, which involves injecting cancer cells via the so-called caudal artery in the mouse tail, overcomes many limitations of traditional mouse models.

30 Jul 2018

Janssen’s Darzalex receives positive CHMP opinion for treating multiple myeloma patients

The Janssen Pharmaceutical Companies of Johnson & Johnson today announced that the Committee for Medicinal Products for Human Use of the European Medicines Agency has recommended broadening the existing marketing authorization for Darzalex® for use as frontline therapy.

28 Jul 2018

Study: Reducing systolic blood pressure lowers MCI, dementia risk

Lowering one's blood pressure is beneficial not only for the heart, but also for the mind. For the first time, researchers have proved that lowering systolic blood pressure to 120 mm Hg or less reduces the risk of mild cognitive impairment, which in turn, reduces one's risk of developing Alzheimer's disease or dementia.

27 Jul 2018

Researchers investigate how nephrologists should discuss treatment options with older patients

Kidney specialists differ in their approaches to treatment decision-making with older patients with kidney failure, with many nephrologists not describing conservative management and some limiting patients' role in decision-making, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society of Nephrology

27 Jul 2018

Novartis' new drug combination receives positive CHMP opinion for treating stage III BRAF mutant melanoma

Novartis today announced the Committee for Medicinal Products for Human Use of the European Medicines Agency has adopted a positive opinion recommending approval of Tafinlar® in combination with Mekinist® for the adjuvant treatment of adult patients with stage III melanoma with a BRAF V600 mutation, following complete resection.

27 Jul 2018

Kidney News and Research

New CAR T-cell immunotherapy trial targets solid tumors

Study could help explain why Asians often develop diabetes at a lower body weight

Young children are more vulnerable to climate-related health risks, shows study

Medicaid expansion increases access to diabetes treatment

Rutgers researchers receive $2.5 million NIEHS grant to study cadmium exposure in expecting mothers

Red blood cells contribute to cardiovascular diseases in patients with type 2 diabetes

Probiotic use could result in disorienting brain fogginess and rapid belly bloating

Study improves understanding of preeclampsia heart damage in pregnancy

Research: Having large muscle size could 'outweigh' poor muscle quality in CKD patients

Scientists map regulatory landscape of mouse genome at single-cell resolution

Otsuka’s JINARC approved for treatment of patients with CKD stage 4 ADPKD

Researchers uncover new mechanisms underlying common kidney cancer in children

Blood samples used to understand repair and regeneration mechanisms of transplanted organs

Gene linked to hair loss could be exploited to improve cancer immunotherapy

FDA approves first therapy for patients with rare tumors of the adrenal gland

New improved mouse model could revolutionize bone metastasis research

Janssen’s Darzalex receives positive CHMP opinion for treating multiple myeloma patients

Study: Reducing systolic blood pressure lowers MCI, dementia risk

Researchers investigate how nephrologists should discuss treatment options with older patients

Novartis' new drug combination receives positive CHMP opinion for treating stage III BRAF mutant melanoma

Event guide: 8th CKD Summit 2026 eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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