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Genetic variant increases heart failure risk and decreases longevity in Black Americans

Researchers at Brigham and Women’s Hospital and Duke University showed that a genetic variant, present in 3-4% of self-identified Black individuals in the U.S., increases the risk for both heart failure and death and contributes to significant decreases in longevity at the population level.

11 May 2024

Expanding treatment horizons for hypermutated urothelial carcinomas beyond immunotherapy

A new editorial paper was published in Oncoscience (Volume 11) on April 25, 2024, entitled, "Therapeutic opportunities for hypermutated urothelial carcinomas beyond immunotherapy."

10 May 2024

DoD grant awarded for investigating alternative polyadenylation in prostate cancer

A team led by Dr. Eddie Imada, assistant professor of research in pathology and laboratory medicine, has been awarded a three-year, $1.5 million United States Department of Defense grant for research on a cellular process called alternative polyadenylation and its role in prostate cancer.

10 May 2024

Drug repurposing breakthrough: varespladib curbs snakebite-induced necrosis

Researchers discovered that venom toxins from African spitting cobras cause severe dermonecrosis, highlighting the need for targeted treatments like the repurposed drug varespladib.

9 May 2024

Combination immunotherapy treatment enhances immune response for people with malignant gliomas

Investigators at the UCLA Health Jonsson Comprehensive Cancer Center have pinpointed a combination immunotherapy treatment that enhances the immune response for people with malignant gliomas, an aggressive type of brain tumor that is fast growing and difficult to treat.

9 May 2024

Ketogenic diet a potential therapy for autism by reshaping gut bacteria and brain inflammation

Modified ketogenic diet modulates gut microbiome, inflammatory markers, and brain-related miRNAs in autistic children, correlating with improved behavioral symptoms. The diet increases beneficial gut bacteria and reduces inflammatory cytokines and BDNF levels.

9 May 2024

Enhancing the ability of natural killer cells to combat hematologic malignancies

A new study reveals a groundbreaking approach to immunotherapy, demonstrating that blocking the interaction between the CD300A receptor and phosphatidylserine (PS) significantly enhances the ability of human natural killer (NK) cells to lyse hematologic malignancies (HMs).

9 May 2024

Relaxation interventions can be offered to lactating parents who would like to improve milk supply and increase well-being

A recent study in JAMA Pediatrics explored the utility of relaxation therapy in increasing milk production in human mothers.

9 May 2024

Novel bispecific antibodies show promise against evolving SARS-CoV-2 variants

Researchers developed bispecific antibodies targeting both the N-terminal and receptor binding domains of SARS-CoV-2, demonstrating significant neutralization across various Omicron variants, suggesting potential for new COVID-19 treatments.

9 May 2024

USC study unveils iron as key driver of lung inflammation in allergic asthma

New USC research shows that iron serves as a gas pedal driving certain immune cells that cause inflammation in the lungs during an allergic asthma attack – and blocking or limiting iron may reduce the severity of symptoms.

8 May 2024

Researchers enhance CAR-T cells to target solid tumors

Researchers at the National Cancer Institute-designated Montefiore Einstein Comprehensive Cancer Center (MECCC) have shown that a breakthrough therapy for treating blood cancers can be adapted to treat solid tumors - an advance that could transform cancer treatment.

8 May 2024

AVAnT1A study: Investigating early COVID-19 vaccination and type 1 diabetes risk in children

Type 1 diabetes is an autoimmune disease that leads to disrupted glucose metabolism. It requires lifelong insulin therapy.

8 May 2024

New clinical guideline released for effectively managing individuals with hypertrophic cardiomyopathy

The American College of Cardiology (ACC) and the American Heart Association (AHA) today released a new clinical guideline for effectively managing individuals diagnosed with hypertrophic cardiomyopathy (HCM).

8 May 2024

Clinical trial shows CRISPR gene editing has exciting potential to treat a rare form of blindness

A recent study published in The New England Journal of Medicine investigated the potential use of gene editing to correct a congenital retinal degeneration called CEP290 that causes early-onset vision loss.

8 May 2024

Intermittent fasting halts liver disease progression and reduces cancer risk

Fatty liver disease often leads to chronic liver inflammation and can even result in liver cancer. Scientists from the German Cancer Research Center (DKFZ) and the University of Tübingen have now shown in mice that intermittent fasting on a 5:2 schedule can halt this development.

8 May 2024

Therapy News and Research

Genetic variant increases heart failure risk and decreases longevity in Black Americans

Expanding treatment horizons for hypermutated urothelial carcinomas beyond immunotherapy

DoD grant awarded for investigating alternative polyadenylation in prostate cancer

Drug repurposing breakthrough: varespladib curbs snakebite-induced necrosis

Combination immunotherapy treatment enhances immune response for people with malignant gliomas

Ketogenic diet a potential therapy for autism by reshaping gut bacteria and brain inflammation

Enhancing the ability of natural killer cells to combat hematologic malignancies

Relaxation interventions can be offered to lactating parents who would like to improve milk supply and increase well-being

Novel bispecific antibodies show promise against evolving SARS-CoV-2 variants

USC study unveils iron as key driver of lung inflammation in allergic asthma

Researchers enhance CAR-T cells to target solid tumors

AVAnT1A study: Investigating early COVID-19 vaccination and type 1 diabetes risk in children

New clinical guideline released for effectively managing individuals with hypertrophic cardiomyopathy

Clinical trial shows CRISPR gene editing has exciting potential to treat a rare form of blindness

Intermittent fasting halts liver disease progression and reduces cancer risk

Compound 12: A promising candidate for heart failure therapy with reduced glucose-lowering activity

Novel head-mounted device shows promise in alleviating depression symptoms

They were shot at the super bowl parade — and might have bullets in their bodies forever

Does your ADHD medication increase your risk of glaucoma?

AI-driven model identifies potent cancer-killing immune cells for personalized immunotherapy

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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