Fatigue News and Research

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Promising results from Exelixis' cabozantinib phase 2 trial against metastatic ovarian cancer

Exelixis, Inc. reported longer follow-up data from a fully enrolled cohort of patients with advanced epithelial ovarian cancer, primary peritoneal carcinoma, or fallopian tube carcinoma treated with cabozantinib (XL184) in an ongoing phase 2 adaptive randomized discontinuation trial. Cabozantinib shows promising activity in these patients independent of prior response to platinum-based therapies.

6 Jun 2011

Alnylam's ALN-VSP Phase I trial data on liver cancer presented at ASCO 2011

Alnylam Pharmaceuticals, Inc., a leading RNAi therapeutics company, announced today the results from its Phase I clinical trial with ALN-VSP, a systemically delivered RNAi therapeutic for the treatment of advanced solid tumors with liver involvement.

6 Jun 2011

Positive results from Plexxikon's vemurafenib Phase 2 and 3 trial against metastatic melanoma

Plexxikon Inc., a member of the Daiichi Sankyo Group, today announced efficacy and safety data from the BRIM3 trial, a large, randomized, multi-center Phase 3 clinical study of vemurafenib in patients with previously untreated metastatic melanoma with the BRAFV600 mutation.

6 Jun 2011

Ross River Fever vaccine trials begin

Australian researchers are working on a new vaccine that could protect against mosquito-borne Ross River Fever. They are conducting the world-first trial of the vaccine with positive results reported so far.

5 Jun 2011

MRSA found in cow’s milk

Scientists have discovered a new strain of the drug-resistant germ known as MRSA in cow’s milk and some evidence that the animals could be a source of the infection in humans.

5 Jun 2011

Five years after cancer treatment, many survivors still suffer symptoms

When people finish treatment for cancer, they want to bounce back to their former vital selves as quickly as possible. But a new Northwestern Medicine study -- one of the largest survivor studies ever conducted - shows many survivors still suffer moderate to severe problems with pain, fatigue, sleep, memory and concentration three to five years after treatment has ended.

4 Jun 2011

Final analysis of AVEO's tivozanib Phase 2 trial on kidney cancer patients presented at ASCO 2011

AVEO Pharmaceuticals, Inc., today announced data from the final analysis of its Phase 2 randomized discontinuation trial evaluating tivozanib, its lead product candidate designed to optimally block the VEGF pathway by inhibiting all three VEGF receptors, in patients with advanced renal cell carcinoma.

2 Jun 2011

Fatigue and poor health may have major impact on patients with functional dysphonia

Fatigue and poor health, anxiety and depression may have a major impact on patients with functional dysphonia (FD), leading to time off work, reduced activity, and social withdrawal, all of which could further perpetuate and/or cause anxiety, low mood, fatigue and reduced voice use, according to new research published in the June 2011 issue of Otolaryngology - Head and Neck Surgery.

2 Jun 2011

Cardiac resynchronization therapy improves sexual health in men with chronic heart failure

A new study published in the journal Clinical Cardiology reveals that in men with chronic heart failure, cardiac resynchronization therapy improves patients' libido, erectile dysfunction, and sexual performance.

2 Jun 2011

Preliminary results from Eisai's lenvatinib Phase II trial in thyroid cancer to be presented at ASCO 2011

Preliminary results of a Phase II single-arm study to be presented at the American Society of Clinical Oncology (ASCO) Annual Meeting showed that Eisai's lenvatinib demonstrated an Objective Response Rate of 59% (34/58, 95% CI: 45-71), based on an updated investigator assessment, in patients with advanced radioiodine (RAI)-refractory differentiated thyroid cancer.

1 Jun 2011

Scientists find no link between XMRV retrovirus and human disease

Delineation of the origin of the retrovirus known as XMRV from the genomes of laboratory mice indicates that the virus is unlikely to be responsible for either prostate cancer or chronic fatigue syndrome in humans, as has been widely published.

1 Jun 2011

Mouse virus not responsible for Chronic Fatigue Syndrome, new study finds

Two years ago, a widely publicized scientific report plucked an old mouse virus out of obscurity and held it up as a possible cause of Chronic Fatigue Syndrome. According to a new study published today by a group of researchers in California, Wisconsin and Illinois, that report was wrong.

1 Jun 2011

Nighttime heart and lung transplants do not affect patient survival

Despite concerns that surgeon fatigue is leading to dangerous complications for patients and data showing worse outcomes for many patients who undergo surgery at night, new Johns Hopkins research suggests that — in the case of heart and lung transplants — time of day has no affect on patient survival.

1 Jun 2011

Sleep loss reduces healthy young man's testosterone levels

Cutting back on sleep drastically reduces a healthy young man's testosterone levels, according to a study published in the June 1 issue of the Journal of the American Medical Association.

1 Jun 2011

Chronic fatigue syndrome and mouse virus – no association

An earlier study published in 2009 had claimed that a mouse virus was the cause of chronic fatigue syndrome. New evidence suggests that this assumption is wrong. According to latest evidence the earlier study findings were likely based on contaminated lab samples, US researchers said Tuesday.

1 Jun 2011

Canadian women more aware of ovarian cancer now, but misconceptions remain

Canadian women know more about ovarian cancer than they did six years ago, but misconceptions remain that could lead to late diagnosis of the country's most fatal gynecologic cancer - a disease that claims the lives of 70% of those diagnosed.

30 May 2011

People with unexplained symptoms can benefit from traditional acupuncture

Attending frequently with medically unexplained symptoms is distressing for both patient and doctor and effective treatment or management options are limited: one in five patients have symptoms that remain unexplained by conventional medicine.

30 May 2011

Short warm-ups improve athlete's power output and help lessen muscle fatigue

University of Calgary Faculty of Kinesiology researcher Elias Tomaras says the idea came to him while watching track and field sprinters warm-up for a race. "If you watch sprinters, short distance speed skaters or cyclists before their race, they will often warm-up for one to two hours, including several brief bouts of high intensity exercise. From an exercise physiology point of view, it seemed like it might be pretty tiring."

30 May 2011

New positive Cimzia phase IIIb study data on rheumatoid arthritis presented at EULAR meeting

UCB today announced data which showed that the addition of Cimzia to current therapy was associated with a rapid and consistent clinical response in a diverse group of rheumatoid arthritis (RA) patients.

30 May 2011

Vitamin D levels low in African Americans with multiple sclerosis

In the first major study exploring the connection between vitamin D and multiple sclerosis in African Americans, a team of scientists at the University of California, San Francisco has discovered that vitamin D levels in the blood are lower in African Americans who have the disease, compared to African Americans who do not.

30 May 2011

Fatigue News and Research

Promising results from Exelixis' cabozantinib phase 2 trial against metastatic ovarian cancer

Alnylam's ALN-VSP Phase I trial data on liver cancer presented at ASCO 2011

Positive results from Plexxikon's vemurafenib Phase 2 and 3 trial against metastatic melanoma

Ross River Fever vaccine trials begin

MRSA found in cow’s milk

Five years after cancer treatment, many survivors still suffer symptoms

Final analysis of AVEO's tivozanib Phase 2 trial on kidney cancer patients presented at ASCO 2011

Fatigue and poor health may have major impact on patients with functional dysphonia

Cardiac resynchronization therapy improves sexual health in men with chronic heart failure

Preliminary results from Eisai's lenvatinib Phase II trial in thyroid cancer to be presented at ASCO 2011

Scientists find no link between XMRV retrovirus and human disease

Mouse virus not responsible for Chronic Fatigue Syndrome, new study finds

Nighttime heart and lung transplants do not affect patient survival

Sleep loss reduces healthy young man's testosterone levels

Chronic fatigue syndrome and mouse virus – no association

Canadian women more aware of ovarian cancer now, but misconceptions remain

People with unexplained symptoms can benefit from traditional acupuncture

Short warm-ups improve athlete's power output and help lessen muscle fatigue

New positive Cimzia phase IIIb study data on rheumatoid arthritis presented at EULAR meeting

Vitamin D levels low in African Americans with multiple sclerosis

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