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DHA and curcumin preserve walking ability in rats with spinal-cord injury

UCLA researchers discovered that a diet enriched with a popular omega-3 fatty acid and an ingredient of curry spice preserved walking ability in rats with spinal-cord injury. Published June 26 in the Journal of Neurosurgery: Spine, the findings suggest that these dietary supplements help repair nerve cells and maintain neurological function after degenerative damage to the neck.

27 Jun 2012

RXi Pharmaceuticals initiates RXI-109 Phase 1 trial to reduce surgical scars

RXi Pharmaceuticals Corporation today announced that it successfully initiated its first ever clinical study with an RNAi compound, RXI-109, using their proprietary self-delivering RNAi technology.

27 Jun 2012

Astellas submits enzalutamide MAA with EMA for treatment of CRPC

Today, Astellas Pharma Inc. announces the submission of a European marketing authorisation application to the European Medicines Agency (EMA) for enzalutamide for the treatment of men with metastatic castration-resistant prostate cancer who have been previously treated with docetaxel-based chemotherapy.

27 Jun 2012

NIH awards Sirnaomics SBIR grant for developing STP705 siRNA wound healing product

Sirnaomics, Inc. announced today that the company has been awarded another NIH SBIR grant for developing its small interfering RNA (siRNA) therapeutic product STP705 to improve skin wound healing with minimized scar formation.

25 Jun 2012

Neuralstem commences dosing in NSI-189 Phase Ib trial for major depressive disorder

Neuralstem, Inc. announced that the first patients were dosed in Phase Ib of its ongoing trial to test the safety of NSI-189 in the treatment of major depressive disorder (MDD).

25 Jun 2012

Novel small-molecule-inhibiting drug stops spread of breast cancer cells

Scientists have developed a small-molecule-inhibiting drug that in early laboratory cell tests stopped breast cancer cells from spreading and also promoted the growth of early nerve cells called neurites.

22 Jun 2012

Emory scientists identify new type of anti-inflammatory compound

Scientists at Emory University School of Medicine have identified a new type of anti-inflammatory compound that may be useful in treating a wide range of conditions, including neurodegenerative and autoimmune diseases. These compounds inhibit the enzyme Nox2, part of a family of enzymes responsible for producing reactive oxygen species (ROS).

22 Jun 2012

Structure of human P-glycoprotein in a moving 3D computer model

A picture is worth 1,000 words when it comes to understanding how things work, but 3D moving pictures are even better. That's especially true for scientists trying to stop cancer by better understanding the proteins that make some chemotherapies unsuccessful.

21 Jun 2012

Furiex initiates MuDelta Phase III studies in IBS-D

Furiex Pharmaceuticals, Inc. today announced dosing of the first patient in its Phase III randomized, double-blind, placebo-controlled studies evaluating efficacy, safety and tolerability of MuDelta (JNJ-27018966) in the treatment of diarrhea-predominant irritable bowel syndrome (IBS-D).

20 Jun 2012

AstraZeneca, Rigel enter global license agreement for R256 inhaled JAK inhibitor to treat chronic asthma

AstraZeneca and Rigel Pharmaceuticals Inc. today announced an exclusive worldwide license agreement for the global development and commercialization of R256, Rigel's inhaled JAK inhibitor shown to inhibit IL-13 and IL-4 signalling, which is being investigated as a treatment for moderate to severe chronic asthma. In preclinical research, R256 has been shown to reduce airway inflammation and improve lung function.

19 Jun 2012

e-Therapeutics commences enrollment in ETS2101 phase I trial for brain cancer

e-Therapeutics plc announces the start of the first clinical trial evaluating its compound ETS2101 as a treatment for cancer. The phase I trial is enrolling patients with primary brain cancer (glioma) or cancer that has spread to the brain from other sites.

19 Jun 2012

Improving outcomes for children with acquired brain injuries a significant challenge

Outcomes for children with brain injury acquired during childhood are difficult to predict and vary significantly, states an analysis of evidence on the topic published in CMAJ (Canadian Medical Association Journal).

19 Jun 2012

Colectomy need in patients with severe ulcerative colitis drastically reduced by Kappaproct

InDex Pharmaceuticals today announced the publication of positive data from the Company's compassionate use program with its lead compound Kappaproct.

19 Jun 2012

Commensal bacteria essential to fight off viral infections

Healthy humans harbor an enormous and diverse group of bacteria and other bugs that live within their intestines. These microbial partners provide beneficial aid in multiple ways - from helping digest food to the development of a healthy immune system.

19 Jun 2012

Militants ban polio vaccination in northwest Pakistan in response to U.S. drone strikes in region

"A Pakistani militant group threatened action on Saturday against anyone conducting polio vaccinations in the region where it is based, saying the health care drive was a cover for U.S. spies," Reuters reports, adding, "The group, based in North Waziristan and led by Hafiz Gul Bahadur, said it had banned vaccinations for as long as U.S. drone aircraft continued to make missile strikes in Pakistan" (Mujtaba, 6/16).

19 Jun 2012

Five abstracts evaluating Abbott's LCIG presented at Parkinson's disease congress

Today Abbott announced results from five abstracts evaluating levodopa-carbidopa intestinal gel (LCIG), its investigational compound for advanced Parkinson's disease.

19 Jun 2012

Bioactive compounds in peaches, plums and nectarines can fight-off diabetes, cardiovascular disease

Peaches, plums and nectarines have bioactive compounds that can potentially fight-off obesity-related diabetes and cardiovascular disease, according to new studies by Texas AgriLife Research.

19 Jun 2012

Cancer publishes Aeterna Zentaris' perifosine Phase 2 trials in RCC

Aeterna Zentaris Inc. today announced that data from two Phase 2 trials in renal cell carcinoma (RCC) for the Company's oral anticancer drug, perifosine, have been published in the June 2012 issue of Cancer, a publication of the American Cancer Society.

18 Jun 2012

Is curry good for you?

There have been several news stories over the years reporting that curry may be good for us. Most of them refer to a chemical in curry, known as curcumin.

18 Jun 2012

FDA completes review of compounded hydroxyprogesterone caproate products and APIs

FDA (or the Agency) approved Makena (hydroxyprogesterone caproate) in February 2011 for the reduction of the risk of certain preterm births in women who have had at least one prior preterm birth. Beginning many years before Makena was approved, a version of the active ingredient of Makena has been available to patients whose physicians requested the drug from a pharmacist who compounded the drug.

18 Jun 2012

Compound News and Research

DHA and curcumin preserve walking ability in rats with spinal-cord injury

RXi Pharmaceuticals initiates RXI-109 Phase 1 trial to reduce surgical scars

Astellas submits enzalutamide MAA with EMA for treatment of CRPC

NIH awards Sirnaomics SBIR grant for developing STP705 siRNA wound healing product

Neuralstem commences dosing in NSI-189 Phase Ib trial for major depressive disorder

Novel small-molecule-inhibiting drug stops spread of breast cancer cells

Emory scientists identify new type of anti-inflammatory compound

Structure of human P-glycoprotein in a moving 3D computer model

Furiex initiates MuDelta Phase III studies in IBS-D

AstraZeneca, Rigel enter global license agreement for R256 inhaled JAK inhibitor to treat chronic asthma

e-Therapeutics commences enrollment in ETS2101 phase I trial for brain cancer

Improving outcomes for children with acquired brain injuries a significant challenge

Colectomy need in patients with severe ulcerative colitis drastically reduced by Kappaproct

Commensal bacteria essential to fight off viral infections

Militants ban polio vaccination in northwest Pakistan in response to U.S. drone strikes in region

Five abstracts evaluating Abbott's LCIG presented at Parkinson's disease congress

Bioactive compounds in peaches, plums and nectarines can fight-off diabetes, cardiovascular disease

Cancer publishes Aeterna Zentaris' perifosine Phase 2 trials in RCC

Is curry good for you?

FDA completes review of compounded hydroxyprogesterone caproate products and APIs

Enhancing confidence in chemical ionization spectrometry data eBook

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

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