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Pediatric acute myeloid leukemia genetic subtypes with poor outcomes show increased inflammatory cytokine signaling

Researchers used ribonucleic acid (RNA) sequence data to understand the association between inflammatory cytokines and poor outcomes of pediatric Acute Myeloid Leukemia (pAML).

29 Nov 2022

Emory doctors join forces with the Family Heart Foundation to help patients with familial hypercholesterolemia

Doctors from the Emory Heart & Vascular Center are joining forces with the Family Heart Foundation, a leading research and advocacy organization, to find and more widely treat undiagnosed patients living with a common genetic condition that causes very high levels of unhealthy cholesterol, heightening the risk for heart attacks and strokes even at a young age.

29 Nov 2022

What genes are associated with asthma exacerbations?

In a new study, researchers reviewed the genomics, transcriptomics, and epigenetics of asthma exacerbations (AEs).

29 Nov 2022

How SARS-CoV-2 immune responses vary by population due to environmental and genetic factors

Researchers investigate the genetic, immunological, and evolutionary factors that determine the vast variability observed in clinical manifestations of COVID-19.

28 Nov 2022

Isolated monoclonal antibodies targeting SARS-CoV-2 S1/S2 cleavage effective against Delta and Omicron

Isolated monoclonal antibodies neutralize SARS-CoV-2 Delta and Omicron variants.

28 Nov 2022

Study reveals a promising therapeutic target for Alzheimer's disease

In a recent search for gene variants associated with Alzheimer's disease (AD), several affected families showed a mutation in an enzyme called protein kinase C-alpha (PKCα). Family members with this mutation had AD; those without the mutation did not.

28 Nov 2022

Scientists unravel how bats harbor many viruses without developing symptoms

Bats are asymptomatic carriers of a multitude of viruses that are pathogenic to most other mammals. How has their immune system evolved to shield them from these pathogens?

28 Nov 2022

Researchers highlight the importance of localizing BRCA gene mutations for better ovarian cancer treatment

Mutations of BRCA1 and BRCA2 genes, which are inherited by 1 in 400 and 1 in 800 people respectively, significantly increase the risk of certain cancers such as ovarian, breast, pancreatic and prostate cancer.

28 Nov 2022

Two studies emphasize the need for ethnically diverse prostate cancer genetic testing

More than 1.4 million men were diagnosed with prostate cancer in 2020 globally, but the molecular characteristics of the disease remain unexplored for the majority of patients around the world.

28 Nov 2022

Molecular and cellular similarities identified in the brains of SARS-CoV-2 and Alzheimer's disease patients

Researchers evaluated neuro-pathophysiological consequences of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, especially the post-acute sequelae of SARS-CoV-2 (PASC) in Alzheimer’s disease (AD) patients.

28 Nov 2022

Characterization of bat viromes reveals the co-infection, spillover, and emergence risk of several zoonotic viruses

Researchers characterized the mammal-infecting viruses in 149 bats, representing six genera and 15 species, sampled from Yunnan province, China using an unbiased meta-transcriptomics approach.

28 Nov 2022

Common chemotherapy drug could carry toxic inheritance for future generations of cancer survivors

A common chemotherapy drug could carry a toxic inheritance for children and grandchildren of adolescent cancer survivors, Washington State University-led research indicates.

28 Nov 2022

Glycan signatures in rheumatic diseases and their associated functional implications

A new paper examines the understanding of glycosylation in an array of rheumatic diseases and indicates the potential for therapeutic interventions using the same mechanism.

28 Nov 2022

How micro(nano)plastics interact with human gut microbiota

In a recent study published in the Microbial Biotechnology journal, researchers explored the health effects of micro(nano)plastics and their degraded products on the gut microbiome.

27 Nov 2022

Scientists develop preclinical model of scrub typhus disease

Scientists have developed an animal model of scrub typhus using outbred CD-1 mice. Using the model, they have characterized host susceptibility to the causative pathogen, disease pathogenesis, and immune responses. The study has been published in the journal PLOS Neglected Tropical Diseases.

27 Nov 2022

Genes News and Research

Pediatric acute myeloid leukemia genetic subtypes with poor outcomes show increased inflammatory cytokine signaling

Emory doctors join forces with the Family Heart Foundation to help patients with familial hypercholesterolemia

What genes are associated with asthma exacerbations?

How SARS-CoV-2 immune responses vary by population due to environmental and genetic factors

Isolated monoclonal antibodies targeting SARS-CoV-2 S1/S2 cleavage effective against Delta and Omicron

Study reveals a promising therapeutic target for Alzheimer's disease

Scientists unravel how bats harbor many viruses without developing symptoms

Researchers highlight the importance of localizing BRCA gene mutations for better ovarian cancer treatment

Two studies emphasize the need for ethnically diverse prostate cancer genetic testing

Molecular and cellular similarities identified in the brains of SARS-CoV-2 and Alzheimer's disease patients

Characterization of bat viromes reveals the co-infection, spillover, and emergence risk of several zoonotic viruses

Common chemotherapy drug could carry toxic inheritance for future generations of cancer survivors

Glycan signatures in rheumatic diseases and their associated functional implications

How micro(nano)plastics interact with human gut microbiota

Scientists develop preclinical model of scrub typhus disease

MicroRNAs play a key role in the development of complex brains

Researchers discover a new function of CRISPR/Cas9 gene scissors

Fossils of a tiny sea creature solve century-old debate over brain evolution in arthropods

New CRISPR-based tool can snip out faulty genes and replace them with new ones

Study provides a key link between the social environment and healthy brains

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