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Princeton researchers employ light to activate new reactivity in existing enzymes

Enzymes are nature's tools for catalyzing life's essential reactions. Though unrivaled in their efficiency and selectivity, enzymes only carry out a narrow range of natural reactions, limiting their usefulness in modern organic synthesis.

21 Dec 2016

Scientists discover link between Huntington's disease and dysfunction of subthalamic nucleus

Northwestern Medicine scientists identified a link between Huntington's disease and dysfunction of the subthalamic nucleus, a component of the basal ganglia, a group of brain structures critical for movement and impulse control.

21 Dec 2016

Research sheds new light on key drivers of cancer metastasis

Latest research from New Zealand's University of Otago is shedding new light on why and how cancer cells spread from primary tumours to other parts of the body. This phenomenon - known as metastasis - causes about 90 per cent of all cancer deaths.

21 Dec 2016

Researchers engineer promising live-attenuated RSV vaccine candidate

Crafting a vaccine against RSV (respiratory syncytial virus) has been a minefield for 50 years, but scientists believe they have found the right balance.

21 Dec 2016

Scientists detail structure of molecule implicated in Alzheimer's disease

Scientists at Washington University School of Medicine in St. Louis have detailed the structure of a molecule that has been implicated in Alzheimer's disease.

21 Dec 2016

Breast cancer patient finds new hope with potentially revolutionary treatment

City of Hope patient Susan Young has had a remarkable response to a potentially revolutionary new treatment, a combination of the p53 cancer vaccine and a drug that blocks a specific cancer-aiding protein.

21 Dec 2016

Genetic mutation may increase susceptibility to cytomegalovirus infection

Experimenting with human cells and mice, Johns Hopkins researchers have found that a genetic mutation that alters a protein called NOD1 may increase susceptibility to human cytomegalovirus (CMV) infection.

20 Dec 2016

Bioinformatics helps identify new, untested drug combinations for treatment of breast cancer

Based on the study of cell signalling networks, the cell signals that drugs alter when they reach their target molecule, an exhaustive in silico analysis of the pairing of 64 therapeutic agents used to treat breast cancer (half already in use and the other half in clinical testing phase) has allowed researchers at the Institute for Research in Biomedicine to identify 10 new and previously untested combinations that hold potential for the treatment of breast cancer.

20 Dec 2016

NCI’s new tool could help accurately predict breast cancer risk in Hispanic patients

A new breast cancer model, published today in the Journal of the National Cancer Institute, will help health care providers more accurately predict breast cancer risk in their Hispanic patients.

20 Dec 2016

Low-carbohydrate diet may help reverse inherited intellectual disability linked to Kabuki syndrome

Experimenting on mice with a genetic change similar to that found in people with a rare inherited disease called Kabuki syndrome, Johns Hopkins scientists report that a very low-carbohydrate diet can "open up" DNA and improve mental function.

20 Dec 2016

Researchers use CRISPR-based genetic screening to identify three promising HIV treatment targets

Investigators from Whitehead Institute, the Ragon Institute of MGH, MIT and Harvard and the Broad Institute of MIT and Harvard have used CRISPR-Cas9 gene-editing technology to identify three promising new targets for treatment of HIV infection.

20 Dec 2016

Landmark clinical trial to test third investigational drug for Alzheimer's disease

An international team led by Washington University School of Medicine in St. Louis has selected a third investigational drug to be tested in a worldwide clinical trial - already underway - aimed at finding treatments to prevent Alzheimer's disease.

20 Dec 2016

FDA awards accelerated approval to new ovarian cancer drug

The U.S. Food and Drug Administration today granted accelerated approval to Rubraca (rucaparib) to treat women with a certain type of ovarian cancer.

19 Dec 2016

Replacing missing gut bacteria could help treat children with rare autoimmune disease

Defects in the body's regulatory T cells (T reg cells) cause inflammation and autoimmune disease by altering the type of bacteria living in the gut, researchers from The University of Texas Health Science Center at Houston have discovered.

19 Dec 2016

Presence of tumor DNA in blood linked to poor outcomes in pancreatic cancer patients

The presence of circulating tumor DNA (ctDNA) isolated from blood samples of patients with pancreatic adenocarcinoma was associated with poor outcomes.

19 Dec 2016

ESMO Asia 2016: Three studies present first data on rare sarcomas in Asian patients

The first data on rare sarcomas in Asian patients is presented in three studies today at the ESMO Asia 2016 Congress in Singapore.

17 Dec 2016

NIH-funded scientists work with three ‘omes’ to understand human health

Have you ever collected coins, cards, toy trains, stuffed animals? Did you feel the need to complete the set? If so, then you may be a completist. A completist will go to great lengths to acquire a complete set of something.

17 Dec 2016

Germline mutations in ATM and BRCA1/2 genes could help predict death risk from aggressive prostate cancer

A study of three genes associated with the development of prostate cancer found that men with inherited mutations in these genes are more likely to develop aggressive forms of the disease and die from prostate cancer at an earlier age than those without the mutations.

17 Dec 2016

Johns Hopkins scientists create bioinformatics tool to evaluate cancer driver gene prediction methods

In their search for new ways to treat cancer, many scientists are using a high-tech process called genome sequencing to hunt for genetic mutations that encourage tumor cells to thrive.

17 Dec 2016

Researchers use worms as model system to study how gut microbiome influences disease

The billions of microorganisms living within the human digestive tract appear to play a significant role in health and disease, notably metabolic syndrome, autoimmune disorders and diabetes - but how these organisms do so is not well understood.

17 Dec 2016

Mutation News and Research

Princeton researchers employ light to activate new reactivity in existing enzymes

Scientists discover link between Huntington's disease and dysfunction of subthalamic nucleus

Research sheds new light on key drivers of cancer metastasis

Researchers engineer promising live-attenuated RSV vaccine candidate

Scientists detail structure of molecule implicated in Alzheimer's disease

Breast cancer patient finds new hope with potentially revolutionary treatment

Genetic mutation may increase susceptibility to cytomegalovirus infection

Bioinformatics helps identify new, untested drug combinations for treatment of breast cancer

NCI’s new tool could help accurately predict breast cancer risk in Hispanic patients

Low-carbohydrate diet may help reverse inherited intellectual disability linked to Kabuki syndrome

Researchers use CRISPR-based genetic screening to identify three promising HIV treatment targets

Landmark clinical trial to test third investigational drug for Alzheimer's disease

FDA awards accelerated approval to new ovarian cancer drug

Replacing missing gut bacteria could help treat children with rare autoimmune disease

Presence of tumor DNA in blood linked to poor outcomes in pancreatic cancer patients

ESMO Asia 2016: Three studies present first data on rare sarcomas in Asian patients

NIH-funded scientists work with three ‘omes’ to understand human health

Germline mutations in ATM and BRCA1/2 genes could help predict death risk from aggressive prostate cancer

Johns Hopkins scientists create bioinformatics tool to evaluate cancer driver gene prediction methods

Researchers use worms as model system to study how gut microbiome influences disease

Improving healthcare sustainability through carbon data

Managing vibration in IVF laboratories

A New Approach to Preventing Bladder Cancer Recurrence

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