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Over-dilation of microvasculature may contribute to chronic limb-threatening ischemia

Persistent over-dilation of muscle microvasculature may be one reason causing chronic limb-threatening ischemia, recent studies by Kuopio University Hospital and the University of Eastern Finland show.

20 Jan 2025

Intermuscular fat increases risk of heart disease independent of BMI

People with pockets of fat hidden inside their muscles are at a higher risk of dying or being hospitalized from a heart attack or heart failure, regardless of their body mass index, according to research published in the European Heart Journal today (Monday).

20 Jan 2025

Retinal vascular features identified as potential predictors of stroke risk

Researchers identify how specific features of the retinal vasculature may help predict an individual’s risk of stroke.

20 Jan 2025

COMET model enhances disease prediction with deep learning

Researchers developed COMET, a deep learning framework that leverages electronic health records and omics data to improve predictive modeling and uncover biological insights.

19 Jan 2025

Stem cell therapy shows promise in restoring brain activity after stroke

Every 40 seconds, someone in the United States has a stroke. For survivors of the most common type of stroke, called an ischemic stroke, only about 5 percent fully recover.

17 Jan 2025

New discovery in HIV vaccine response reveals surprising antibody behavior

Many vaccines work by introducing a protein to the body that resembles part of a virus. Ideally, the immune system will produce long-lasting antibodies recognizing that specific virus, thereby providing protection.

17 Jan 2025

Early pregnancy weight gain contributes to excess fat distribution in fetuses

Fetuses of pregnant people who gained excess weight in the first trimester of pregnancy show signs of excess fat distribution in the upper arm and in the abdomen, according to a study by researchers at the National Institutes of Health.

17 Jan 2025

Study reveals brain aging in sickle cell patients

Individuals with sickle cell disease – a chronic illness where misshapen, sticky blood cells clump together, reducing oxygen delivery to organs – are at a higher risk for stroke and resulting cognitive disability.

17 Jan 2025

Cigarette smoke alters immune cell function in the lungs

Cigarette smoking is widespread and deadly, yet our understanding of how cigarette smoke actually causes serious respiratory illnesses is incomplete, which has severely hampered the development of effective treatments.

17 Jan 2025

Extracellular vesicle miRNAs as potential early biomarkers for acute myocardial infarction

Announcing a new article publication for Cardiovascular Innovations and Applications journal. This study sought to determine the potential of extracellular vesicle (EV) microRNAs (miRNAs) to serve as early diagnostic biomarkers for AMI.

17 Jan 2025

Exploring the role of EpCAM in early-stage hepatocellular carcinoma progression

Announcing a new publication for Acta Materia Medica journal. Epithelial cell adhesion molecule (EpCAM) is a biomarker for epithelial cell-derived tumors.

17 Jan 2025

Researchers investigate myocarditis in preschoolers caused by parvovirus B19 outbreak

Researchers document the harmful consequences of myocarditis in preschool students, caused by a regional outbreak of parvovirus B19 in northern Greece.

17 Jan 2025

Inflammasome proteins found to prevent cancer by regulating stem cells

A group of immune proteins called the inflammasome can help prevent blood stem cells from becoming malignant by removing certain receptors from their surfaces and blocking cancer gene activity, according to a preclinical study by Weill Cornell Medicine investigators.

17 Jan 2025

Intestinal bacterium found to reduce sugar intake in diabetic mice and humans

Excessive sugar consumption is linked to several non-communicable diseases, including obesity, cardiovascular disease, metabolic syndrome, and type 2 diabetes.

17 Jan 2025

Early brain changes in Huntington’s disease detected two decades before symptoms

Subtle changes in the brain, detectable through advanced imaging, blood and spinal fluid analysis, happen approximately twenty years before a clinical motor diagnosis in people with Huntington's disease, finds a new study led by UCL researchers.

17 Jan 2025

Tofacitinib reduces SARS-CoV-2 infection risk in patients with PTPN2 deficiency

Researchers report the ability of tofacitinib to reduce infection risk with SARS-CoV-2 in individuals who are deficient in PTPN2.

17 Jan 2025

Triple-drug chemo fails to improve survival in advanced biliary tract cancer

The results of a clinical trial led by researchers at the University of Arizona Health Sciences and published in the Journal of Clinical Oncology showed that chemotherapy combining three different types of drugs did not improve overall survival for patients with advanced stage, inoperable biliary tract cancers.

17 Jan 2025

Study reveals high prevalence of Lyme disease bacteria in Northeast ticks

Across most of the Northeast, getting bitten by a blacklegged tick- also called a deer tick - is a risk during spring, summer, and fall. A new Dartmouth study, published in Parasites and Vectors, finds that 50% of adult blacklegged ticks carry the bacteria that causes Lyme disease while 20% to 25% of the younger (nymph) blacklegged ticks carry the bacteria.

17 Jan 2025

Immune cells orchestrate glucagon production during fasting

When we think about the immune system, we usually associate it with fighting infections. However, a study published in Science by the Champalimaud Foundation reveals a surprising new role.

17 Jan 2025

Non-toxic bacterial therapy shows promise for targeting tumors

A University of Massachusetts Amherst-Ernest Pharmaceuticals team of scientists has made "exciting," patient-friendly advances in developing a non-toxic bacterial therapy, BacID, to deliver cancer-fighting drugs directly into tumors.

16 Jan 2025