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Study suggests revolutionary way to make cancer cells more susceptible to existing chemotherapies

The same signal that drives aggressive growth in a deadly cancer cell type also triggers coping mechanisms that make it "notoriously" hard to kill, according to a study published online December 15 in Cell. When stressed, this cell type - far more than most cancer cells - encases its genetic messages in protein globs called "stress granules" that lessen the effect of chemotherapies.

16 Dec 2016

Researchers develop new method to identify antigens for cancer treatment

New cancer therapies harness the immune system to fight tumors. One of the main principles behind these therapies is to find out precisely which molecules on cancer cells trigger an immune response.

16 Dec 2016

UK to officially authorise clinical use of ground-breaking ‘three-person baby IVF’

The United Kingdom will likely this week become the first country to officially authorise clinical use of ground-breaking mitochondrial donation IVF to enable healthy babies to be born to women carrying deadly mitochondrial disease, which starves major organs of energy.

16 Dec 2016

URMC researchers identify potential new means of treating severe genetic diseases in children

University of Rochester Medical Center researchers believe they have identified a potential new means of treating some of the most severe genetic diseases of childhood, according to a study in PLOS Biology.

16 Dec 2016

Research findings could offer novel approach for cancer prevention in women with BRCA1 mutations

Women with inherited mutations in the BRCA1 or BRCA2 genes are at substantially higher risk of breast cancer. For these women, effective prevention strategies are their best hope to reduce their breast cancer risk.

16 Dec 2016

Researchers identify new gene fusions and mutations linked to subset of GIST patients

In recent years, researchers have identified specific gene mutations linked to gastrointestinal stromal tumors (GIST), which primarily occur in the stomach or small intestine, with 5,000 to 6,000 new cases per year in the United States.

16 Dec 2016

Scientists discover possible way to stop activation of proteins known to cause age-related diseases

Researchers at the University of Surrey, in collaboration with the Universities of Reading and Cologne, and the Royal Berkshire Hospital, have discovered that it is possible to stop the activation of a group of proteins (NADPH Oxidase) known to cause most of the diseases of ageing.

15 Dec 2016

New technique uses focused ultrasound to detect cancer biomarkers in the blood

Each year, thousands of Canadian men with prostate cancer undergo biopsies to help their doctors better understand the progression and nature of their disease. It provides vital, sometimes life-saving information, yet cancer researcher John Lewis knows it can be a difficult test to ask of anyone.

15 Dec 2016

New study may shed light on diseases associated with mutations in aminoacyl tRNA synthetases

New research led by scientists at The Scripps Research Institute reveals that a human enzyme has changed little from its days as a bacterial enzyme. In fact, the enzyme appears to be unique in its ability to change its shape—and its job in cells—without overhauling its basic architecture.

14 Dec 2016

Study identifies recurrent genomic alterations in subset of breast cancer

A genomic analysis study by Rutgers Cancer Institute of New Jersey investigators and other colleagues has identified recurrent genomic alterations in a subset of breast cancer that are typically associated with a form of thyroid cancer and an intestinal birth defect known as Hirschsprung disease.

9 Dec 2016

Researchers uncover first ‘off-switches’ for better control of CRISPR/Cas9 gene editing

CRISPR/Cas9 genome editing is quickly revolutionizing biomedical research, but the new technology is not yet exact. The technique can inadvertently make excessive or unwanted changes in the genome and create off-target mutations, limiting safety and efficacy in therapeutic applications.

9 Dec 2016

Researchers crack genetic code of lung tissues to identify novel targets for treating IPF

Researchers cracked the complete genetic code of individual cells in healthy and diseased human lung tissues to find potential new molecular targets for diagnosing and treating the lethal lung disease Idiopathic Pulmonary Fibrosis (IPF).

8 Dec 2016

Study reveals men diagnosed with prostate cancer more likely to die of other diseases

Starting in 1993 and ending in 2001, ten academic medical centers in the United States screened 76,685 men and 78,216 women for prostate, lung, colorectal and ovarian cancers.

8 Dec 2016

Duke researchers develop new cell-based drug screening test for dystonia

Duke University researchers have identified a common mechanism underlying separate forms of dystonia, a family of brain disorders that cause involuntary, debilitating and often painful movements, including twists and turns of different parts of the body.

8 Dec 2016

Scientists identify biomarkers to predict patient’s response to breast cancer treatment

Why do some breast cancers respond to treatment while others resist it? A study led by researchers at the University of North Carolina Lineberger Comprehensive Cancer Center may provide insight into this important question.

8 Dec 2016

Scientists discover truncated p53 proteins that promote cancer growth and metastasis

Discovered in the 1970s, tumor suppressors are among the most important proteins in the body.

8 Dec 2016

Scientists use unified analysis approach for diagnosing diseases with multiple genetic causes

Scientists at Baylor College of Medicine, Baylor Genetics, the University of Texas Health Science Center at Houston and Texas Children's Hospital are combining descriptions of patients' clinical features with their complex genetic information in a unified analysis to obtain more precise diagnoses of complex diseases, particularly those that involve more than one gene causing the condition.

8 Dec 2016

Researchers developing model to predict breast cancer patient’s response to chemotherapy

University of North Carolina Lineberger Comprehensive Cancer Center researchers and collaborators are working to predict, before treatment, whether an aggressive type of breast cancer will respond to chemotherapy.

8 Dec 2016

Dental problems linked to cleft lip and palate may be caused by abnormal salivary glands

A new study in the Journal of Dental Research suggests that dental problems commonly associated with cleft lip and palate may be caused by abnormalities in salivary glands and an imbalance of immune compounds in the mouth.

7 Dec 2016

Older women with metastatic breast cancer more likely to have genetic alterations in tumors

A University of North Carolina Lineberger Comprehensive Cancer Center-led analysis has found that women who are 65 years or older with metastatic breast cancer were more likely to have a cancer-linked genetic alterations in their tumors, and had a larger total number of genetic alterations, than younger patients overall.

7 Dec 2016

Mutation News and Research

Study suggests revolutionary way to make cancer cells more susceptible to existing chemotherapies

Researchers develop new method to identify antigens for cancer treatment

UK to officially authorise clinical use of ground-breaking ‘three-person baby IVF’

URMC researchers identify potential new means of treating severe genetic diseases in children

Research findings could offer novel approach for cancer prevention in women with BRCA1 mutations

Researchers identify new gene fusions and mutations linked to subset of GIST patients

Scientists discover possible way to stop activation of proteins known to cause age-related diseases

New technique uses focused ultrasound to detect cancer biomarkers in the blood

New study may shed light on diseases associated with mutations in aminoacyl tRNA synthetases

Study identifies recurrent genomic alterations in subset of breast cancer

Researchers uncover first ‘off-switches’ for better control of CRISPR/Cas9 gene editing

Researchers crack genetic code of lung tissues to identify novel targets for treating IPF

Study reveals men diagnosed with prostate cancer more likely to die of other diseases

Duke researchers develop new cell-based drug screening test for dystonia

Scientists identify biomarkers to predict patient’s response to breast cancer treatment

Scientists discover truncated p53 proteins that promote cancer growth and metastasis

Scientists use unified analysis approach for diagnosing diseases with multiple genetic causes

Researchers developing model to predict breast cancer patient’s response to chemotherapy

Dental problems linked to cleft lip and palate may be caused by abnormal salivary glands

Older women with metastatic breast cancer more likely to have genetic alterations in tumors

Improving healthcare sustainability through carbon data

Managing vibration in IVF laboratories

A New Approach to Preventing Bladder Cancer Recurrence

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