Huntington’s Disease News and Research

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New potential therapy for Huntington disease

Medical researchers at the University of Alberta have discovered a promising new therapy for Huntington disease that restores lost motor skills and may delay or stop the progression of the disease based on lab model tests, says the lead researcher.

14 Feb 2012

Prosensa secures €23M in new equity financing

Prosensa, the Dutch biopharmaceutical company focusing on RNA-modulating therapeutics for rare diseases with high unmet needs, announced today that it has raised €23 million in new equity financing.

25 Jan 2012

MSC-mediated RNAi transfer holds promise for Huntington's disease

A team of researchers at the UC Davis Institute for Regenerative Cures has developed a technique for using stem cells to deliver therapy that specifically targets the genetic abnormality found in Huntington's disease, a hereditary brain disorder that causes progressive uncontrolled movements, dementia and death.

20 Jan 2012

Detroit to get first new hospital in 30 years; Dallas' Parkland hospital safety report 'imminent'

The Detroit Medical Center today broke ground for a new $78 million, five-story heart hospital scheduled to open on the health system's midtown Detroit campus in two years. The new DMC Heart Hospital is the first hospital to open in Detroit in 30 years. ... The new building is a major turning point for a program that "hit rock bottom" eight years ago, Duggan said, when cardiologists and heart surgeons left for jobs in the suburbs and open-heart surgery operations declined here.

19 Jan 2012

First Edition: January 18, 2012

In today's headlines, a report about the number of people in the U.S. who live in households receiving government benefits.

18 Jan 2012

Defects in mitochondria lead to devastating neurodegenerative disease

A devastating neurodegenerative disease that first appears in toddlers just as they are beginning to walk has been traced to defects in mitochondria, the 'batteries' or energy-producing power plants of cells. This finding by a team of researchers, led by investigators from the Montreal Neurological Institute and Hospital - The Neuro- at McGill University, was published in this week's issue of the Proceedings of the National Academy of Sciences of the USA.

18 Jan 2012

Scientists identify compound that can help repair toxic RNA defect

Scientists from the Florida campus of The Scripps Research Institute have identified a compound that can help repair a specific type of defect in RNA, a type of genetic material.

18 Jan 2012

Lack of iron early in life can affect brain's physical structure

Iron is a popular topic in health news. Doctors prescribe it for medical reasons, and it's available over the counter as a dietary supplement. And while it's known that too little iron can result in cognitive problems, it's also known that too much promotes neurodegenerative diseases. Now, researchers at UCLA have found that in addition to causing cognitive problems, a lack of iron early in life can affect the brain's physical structure as well.

12 Jan 2012

Disruption of circadian rhythms cause accelerated neurodegeneration and premature death

New research at Oregon State University provides evidence for the first time that disruption of circadian rhythms - the biological "clocks" found in many animals - can clearly cause accelerated neurodegeneration, loss of motor function and premature death.

11 Jan 2012

Studies identify genes and small molecules against protein conformational diseases

Two related studies from Northwestern University offer new strategies for tackling the challenges of preventing and treating diseases of protein folding, such as Alzheimer's, Parkinson's and Huntington's diseases, amyotrophic lateral sclerosis (ALS), cancer, cystic fibrosis and type 2 diabetes.

7 Jan 2012

Scripps professor receives pair of notable grants to study kinesin

Sathyanaryanan Puthanveettil, an assistant professor on the Florida campus of The Scripps Research Institute, has been awarded a pair of notable grants to study a critical component of long-term memory formation.

6 Jan 2012

DNA stays too tightly wound in brain cells of patients with schizophrenia

Scientists at The Scripps Research Institute have discovered that DNA stays too tightly wound in certain brain cells of schizophrenic subjects. The findings suggest that drugs already in development for other diseases might eventually offer hope as a treatment for schizophrenia and related conditions in the elderly.

28 Dec 2011

Researchers discover key interaction at heart of promising new treatment for Fabry disease

A research team led by biochemist Scott Garman at the University of Massachusetts Amherst has discovered a key interaction at the heart of a promising new treatment for a rare childhood metabolic disorder known as Fabry disease.

23 Dec 2011

UCL awarded 20M grant to establish The Leonard Wolfson Experimental Neurology Centre

A new centre dedicated to the understanding and treatment of neurodegenerative diseases will be established at UCL following the award of a -20million grant from the Wolfson Foundation, it was announced today.

19 Dec 2011

UCL to establish new center for treatment of neurodegenerative diseases

A new centre dedicated to the understanding and treatment of neurodegenerative diseases will be established at UCL following the award of a £20million grant from the Wolfson Foundation, it was announced today.

19 Dec 2011

Increased Sirt1 expression protects against neurodegeneration in HD mouse model

Treatment that increases brain levels of an important regulatory enzyme may slow the loss of brain cells that characterizes Huntington's disease (HD) and other neurodegenerative disorders.

19 Dec 2011

SIRT1 gene appears to delay onset of HD in mouse model

Working with genetically engineered mice, Johns Hopkins researchers have discovered that a gene (SIRT1) linked to slowing the aging process in cells also appears to dramatically delay the onset of Huntington's disease (HD) and slow the progression of the relentless neurodegenerative disorder.

19 Dec 2011

New drug candidate may halt mental decline of Alzheimer's

A new drug candidate may be the first capable of halting the devastating mental decline of Alzheimer's disease, based on the findings of a study published today in PLoS one.

15 Dec 2011

DFG to establish eight new CRCs as of 1 January 2012

The Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) will establish eight Collaborative Research Centres (CRC) as of 1 January 2012. This was agreed by the responsible Grants Committee at its autumn meeting in Bonn.

5 Dec 2011

Dye derived from Canary Island lichens may help treat Alzheimer's disease

A red dye derived from lichens that has been used for centuries to color fabrics and food appears to reduce the abundance of small toxic protein aggregates in Alzheimer's disease. The dye, a compound called orcein, and a related substance, called O4, bind preferentially to small amyloid aggregates that are considered to be toxic and cause neuronal dysfunction and memory impairment in Alzheimer's disease.

3 Dec 2011