Immunodeficiency News and Research

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Immunodeficiency (or immune deficiency) is a state in which the immune system's ability to fight infectious disease is compromised or entirely absent.

Assessing an intranasal lentiviral booster against COVID-19 variants

A new study explores the possibility of vaccination via nasal route utilizing a lentiviral vaccination vector (LV) to be administered as a booster dose against COVID-19.

2 Feb 2022

Study highlights importance of immunizing and boosting PAD syndromes patients with SARS-CoV-2 mRNA vaccines

A new study posted to the medRxiv* preprint server has evaluated the effect of mRNA-based COVID-19 vaccination and boosting strategy on serum antibody responses in PAD patients against the original SARS-CoV-2 strain and circulating variants.

31 Jan 2022

Magnetic nanoparticles for SARS-CoV-2 and other virus detection systems

Researchers discuss the contributions that have been provided by magnetic nanoparticles for the molecular diagnosis of human viruses.

28 Jan 2022

Exploring receptor-blocking conserved non-neutralizing antibodies for SARS-CoV-2 therapy

In a new study, researchers hypothesized and developed broad-spectrum SARS-CoV-2 inhibitors, ReconnAbs, by modifying the existing non-neutralizing antibodies targeted towards the highly conserved epitopes of the SARS-CoV-2 spike (S) protein combined with a receptor-blocking component.

28 Jan 2022

Effects of multi-nutrient supplementation on COVID-19 severity in elderly patients

In a new study, researchers analyzed the effects of multi-nutrient supplementation on SARS-CoV-2 vaccine efficacy and the overall improvement of respiratory and muscle function in elderly COVID-19 patients.

27 Jan 2022

T-cell apoptosis linked to poor prognosis among COVID-19 patients

Researchers assess the probability of T-cell apoptosis in patients with severe COVID-19 who were admitted to the hospital.

26 Jan 2022

Male clients of sex workers more likely to be living with HIV compared to other men

Twenty years' worth of surveys suggest that nearly one in ten sexually active men in 35 countries in sub-Saharan Africa have been clients of sex workers, and these men are about 50 percent more likely to be living with human immunodeficiency virus (HIV).

25 Jan 2022

Development of synthetic molecules that can bridge T cells with SARS-CoV-2 infected cells

Scientists have recently used synthetic biology to design primary human CD8 T cells to express Spike protein-specific chimeric antigen receptors (ACE2 CAR or anti-Spike CAR).

25 Jan 2022

Novel SARS-CoV-2 mutations reported in chronic HIV patients

A new study describes the emergence of new SARS-CoV-2 variants in three immunocompromised patients.

23 Jan 2022

Study reveals how state laws affect access to HIV pre-exposure prophylaxis

State laws in the US that require medical doctors (MDs) to determine which medications a nurse practitioner (NP) or physician assistant (PA) can prescribe, and under what conditions, may limit the number of patients who use HIV pre-exposure prophylaxis (PrEP), reports a study in The Journal of the Association of Nurses in AIDS Care.

22 Jan 2022

Exploring the potential utility of calcium channel inhibitors in SARS-CoV-2 infection

In a new study, researchers discuss the role of calcium signaling pathways as targets of inhibition in potential new antiviral therapeutic pathways for SARS-CoV-2.

20 Jan 2022

Study explores COVID-19 diagnosis and outcomes in HIV patients

In a new study, researchers determined the effect of the human immunodeficiency virus (HIV) on coronavirus disease 2019 (COVID-19) diagnosis and disease outcomes and compared to those without HIV.

19 Jan 2022

Macrodomains represent a unique target for pathogens with pandemic potential

In a new study published in the journal Pathogens, researchers have summarized the role of the macrodomain in viral replication and virulence and further reviewed the development of macrodomain inhibitors as antiviral agents.

18 Jan 2022

South African study confirms SARS-CoV-2 Omicron less severe than Delta even for unvaccinated

Researchers compare the outcomes of the fourth and previous waves of the COVID-19 pandemic in South Africa.

17 Jan 2022

Study demonstrates that intra-host SARS-CoV-2 variants with reduced infectivity are developed during infection

A new paper discusses the appearance of quasi-species in a single host with prolonged infection, with different rates of infectivity and sensitivity to neutralization by antibodies elicited by the Pfizer vaccine or those present in convalescent plasma.

17 Jan 2022

Immunodeficiency News and Research

Further Reading

Assessing an intranasal lentiviral booster against COVID-19 variants

Study highlights importance of immunizing and boosting PAD syndromes patients with SARS-CoV-2 mRNA vaccines

Magnetic nanoparticles for SARS-CoV-2 and other virus detection systems

Exploring receptor-blocking conserved non-neutralizing antibodies for SARS-CoV-2 therapy

Effects of multi-nutrient supplementation on COVID-19 severity in elderly patients

T-cell apoptosis linked to poor prognosis among COVID-19 patients

Male clients of sex workers more likely to be living with HIV compared to other men

Development of synthetic molecules that can bridge T cells with SARS-CoV-2 infected cells

Novel SARS-CoV-2 mutations reported in chronic HIV patients

Study reveals how state laws affect access to HIV pre-exposure prophylaxis

Exploring the potential utility of calcium channel inhibitors in SARS-CoV-2 infection

Study explores COVID-19 diagnosis and outcomes in HIV patients

Macrodomains represent a unique target for pathogens with pandemic potential

South African study confirms SARS-CoV-2 Omicron less severe than Delta even for unvaccinated

Study demonstrates that intra-host SARS-CoV-2 variants with reduced infectivity are developed during infection

Similarities and dissimilarities in immune responses and metabolism in SARS-CoV-2 and HIV-1 infections

Humoral and cellular response to primary and booster COVID-19 vaccination in immunosuppressed patients

Moderna announces initiation of Phase 1 study of its mRNA-1189 EBV vaccine candidate

Serological antibody response to SARS-CoV-2 infection at a population level

Researchers discover how oral bacteria increase vulnerability to infection

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