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Researchers identify pathway to resolve allergic asthma

A group of Brazilian researchers succeeded in preventing allergic asthma from progressing in experimental models by increasing the amount of a protein. This increase, in turn, blocked the CD4+ T lymphocytes responsible for producing a cytokine that triggers a cascade of events resulting in the onset and progression of the disease.

6 Nov 2018

Study: Single protein regulates network of genes essential for sperm development

A single protein regulates a battery of key genes inside developing sperm, according to a new study out of Case Western Reserve University School of Medicine.

31 Oct 2018

Research provides insight into neurobiology of aggression and bullying

Duke-NUS researchers have discovered that a growth factor protein, called brain-derived neurotrophic factor, and its receptor, tropomyosin receptor kinase B affects social dominance in mice. The research has implications for understanding the neurobiology of aggression and bullying.

20 Oct 2018

Researchers discover why heart contractions are weaker in individuals with HCM

When a young athlete suddenly dies of a heart attack, chances are high that they suffer from familial hypertrophic cardiomyopathy. Itis the most common genetic heart disease in the US and affects an estimated 1 in 500 people around the world.

17 Oct 2018

New transgenic mouse model sheds light on biological causes of Parkinson's disease

Parkinson's disease is a neurodegenerative disorder that presents clinically with abnormal movement and tremors at rest.

12 Oct 2018

Periodontal disease may be an initiator of Alzheimer's

Long-term exposure to periodontal disease bacteria causes inflammation and degeneration of brain neurons in mice that is similar to the effects of Alzheimer's disease in humans, according to a new study from researchers at the University of Illinois at Chicago.

4 Oct 2018

Researchers insert just enough human DNA into mice to study preterm birth

Preterm birth remains a global epidemic linked to a lifetime of potential health complications. It also is difficult to study in living creatures--especially the uniquely precise biology of preterm birth in humans.

3 Oct 2018

Olfactory cells could act as 'Trojan horse,' delivering anticancer therapy to dangerous brain tumors

A special type of cell essential to the ability of olfactory neurons to regenerate may be genetically engineered to deliver anticancer therapy to the dangerous brain tumors called glioblastomas.

27 Sep 2018

Genervon reports new findings that drug candidate GM6 attenuates Alzheimer's disease in mice model

Following the closure of several research programs for Alzheimer's disease, in early 2018 the FDA issued a release entitled "Draft Guidance for Industry: Early Alzheimer's Disease: Developing Drugs for Treatment." Encouraged by the proposed changes in the new guidance, Genervon's research team reported new findings that its drug candidate GM6 attenuates Alzheimer's disease in an early AD transgenic APP mice model.

25 Sep 2018

Toxicological evaluation and dosimetry estimation of potential PET radiotracer

The SR101 N-(3-[18F]Fluoropropyl) sulfonamide ([18F]SRF101) is a Sulforhodamine 101 derivative that was previously synthesized by our group.

25 Sep 2018

Researchers highlight potential therapy for treating rare, deadly blood-clotting disorder

In proof-of-concept experiments, University of Alabama at Birmingham researchers have highlighted a potential therapy for a rare but potentially deadly blood-clotting disorder, TTP.

24 Sep 2018

Researchers identify new genetic disorder in a human patient

Researchers from Michigan State University College of Human Medicine and physicians from Spectrum Health have identified for the first time in a human patient a genetic disorder only previously described in animal models.

21 Sep 2018

Study: Neural signal that urges to eat overpowers the one that says to stop

Almost everyone knows the feeling. You're at a restaurant or a holiday meal, and your stomach is telling you it's full, so logically you know you should stop eating.

21 Sep 2018

Research team to investigate how blood flow influences formation of plaque

Atherosclerosis - the narrowing of arteries due to plaque buildup - is the underlying reason for the majority of strokes and heart attacks. When atherosclerosis occurs in the arteries that carry blood to the heart muscle, it is called coronary artery disease, the No. 1 killer of Americans.

30 Aug 2018

Gene therapy with telomerase does not increase cancer risk, study shows

Negative results and findings in science are perhaps less newsworthy, but they are no less important. Particularly when, as in this case, they demonstrate that a possible new therapeutic pathway against idiopathic pulmonary fibrosis and other diseases associated to short telomeres is in fact safe.

21 Aug 2018

Transgenic rice plant extracts could help stop the spread of HIV

Extracts from transgenic rice plants could help stop the spread of HIV, according to research results from an international effort that included an Iowa State University scientist.

17 Aug 2018

New polyclonal immunotherapy successfully neutralizes Ebola virus

SAB Biotherapeutics, Inc., a clinical-stage biopharmaceutical company, today announced that its anti-Ebola immunotherapy (SAB-139) provided "100% protection against a lethal dose of the Ebola virus" in a recent animal study published in The Journal of Infectious Diseases.

15 Aug 2018

New study focuses on promise of gene therapy for Amish nemaline myopathy

A new comprehensive natural history study about Amish nemaline myopathy in the Old Order Amish population focuses on the promise of gene therapy for this lethal disorder.

14 Aug 2018

Study identifies key gene to accelerate sugarcane growth

Despite international breeding efforts, advanced agronomy and effective management of pests and diseases, sugarcane yields have been static for decades owing to constraints on culm development.

6 Aug 2018

FAU and partners receive NIH research grant to shed light on sleep loss and metabolic disorders

A neuroscientist from Florida Atlantic University's Jupiter Life Science Initiative and collaborators from the University of Minnesota and Stowers Institute for Medical Research recently a received a four-year, $1.68 million R01 research grant from the National Institutes of Health's National Institute of General Medical Sciences for a project titled, "Understanding Complex Trait Architecture through Population Genomics."

17 Jul 2018