Whole Genome Sequencing News and Research

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New insights could help unlock the mystery of how lung cancer arises in never smokers

A genomic analysis of lung cancer in people with no history of smoking has found that a majority of these tumors arise from the accumulation of mutations caused by natural processes in the body.

6 Sep 2021

Patients who contract SARS-CoV-2 Delta variant more likely to be hospitalized than those with Alpha

Recently, researchers found the risk of being hospitalized was two times higher for people with the Delta variant as compared to those with the Alpha variant.

6 Sep 2021

Increased evolutionary rates seen in SARS-CoV-2 variants of concern

An Australian study conducted at the University of Melbourne describes that the emergence of more deadly variants of concern (VOCs) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with an induction in episodic evolutionary rate. The study is currently available on the medRxiv* preprint server.

2 Sep 2021

Studies outlines novel strategies for detecting cancer and minimal residual disease

The latest special issue of PLOS Medicine features five studies outlining novel strategies for detecting cancer and for identifying minimal residual disease - when a small number of tumor cells survive treatment, potentially leading to recurrence of cancer.

1 Sep 2021

Liquid biopsies could help identify, track bladder cancer and peripheral nerve tumors

Liquid biopsies detect tumor DNA in blood or urine samples. Two studies led by Washington University School of Medicine in St. Louis describe the potential of liquid biopsies to identify and track tumor growth in two very different cancers: bladder cancer and peripheral nerve tumors.

31 Aug 2021

Blood test could enable early detection of cancer in people with neurofibromatosis type 1

People with an inherited condition known as neurofibromatosis type 1, or NF1, often develop non-cancerous, or benign, tumors that grow along nerves. These tumors can sometimes turn into aggressive cancers, but there hasn't been a good way to determine whether this transformation to cancer has happened.

31 Aug 2021

Genomic autopsy reveals many genetic variants associated with cardiomyopathy

Postmortem genetic testing, or genomic autopsy, of young individuals who experienced sudden death revealed many had known genetic variants that are associated with cardiomyopathy, according to a Northwestern Medicine study published in JAMA Cardiology.

31 Aug 2021

Anti-SARS-CoV-2 immunity induced by Pfizer/BioNTech vaccine may decline after 6 months

A team of scientists from Israel has recently claimed that antiviral immunity induced by the mRNA-based coronavirus disease 2019 (COVID-19) BNT162b2 gradually declines over time, highlighting the need for a third booster dose.

31 Aug 2021

Study compares risk of hospitalization from SARS-CoV-2 delta and alpha variants

Largest study to date analyzing more than 40,000 COVID-19 cases (including a combination of vaccinated and unvaccinated individuals) confirmed by virus genome sequencing finds a two-fold increased risk of hospitalization from delta versus alpha variant infections.

31 Aug 2021

Prevalence of vaccine breakthrough cases in SF Bay Area

A new study focuse on studying breakthrough infections in a highly vaccinated community owing to the emergence of SARS-CoV-2 variants.

30 Aug 2021

Could genetic variants in host cell receptors (ACE2) explain COVID-19 susceptibility among certain ethnic groups?

Led by Ioannis Karakikes of Stanford University, a new study suggests some hospitalized patients with COVID-19 contain ACE2 genetic variants that increase ACE2 expression. Some variants that altered ACE2 protein expression and binding affinity were more prevalent in people with European backgrounds.

30 Aug 2021

Molecular autopsy of dried blood spots can identify underlying cause of sudden cardiac death in a young person

The underlying cause of sudden cardiac death (SCD) in a young person is often difficult to identify. A genetic analysis could provide more information in many cases, but blood samples are not collected routinely at the time of death, and DNA extracted from the tissues collected at autopsy is damaged because of the way they are fixed in formalin and paraffin-embedded.

30 Aug 2021

SARS-CoV-2 alpha variant increased COVID-19 severity in Scotland's 3rd wave

A team of UK-based scientists has recently revealed that the alpha variant (B.1.1.7) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the third pandemic wave in Scotland and that the variant is associated with more severe coronavirus disease 2019 (COVID-19). The study is currently available on the medRxiv* preprint server.

25 Aug 2021

Study on SARS-CoV-2 Delta breakthrough infections shows twice the risk as Alpha

A recent study conducted by Portuguese scientists has claimed that mRNA-based coronavirus disease 2019 (COVID-19) vaccines are less effective against the delta variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Moreover, in breakthrough infections by delta variant, vaccines are less effective in reducing viral loads. The study is currently available on the medRxiv* preprint server.

25 Aug 2021

SARS-CoV-2 Delta variant associated with more breakthrough infections

The study highlights that compared to the previously circulating alpha variant, the delta variant is associated with higher infectious virus load and a lower level of humoral immunity in the upper respiratory tract. The study is currently available on the medRxiv* preprint server prior to peer review.

24 Aug 2021

FDA and Mexican counterparts report accomplishments and set goals for future food safety partnership

As part of our ongoing efforts to ensure the safety of food imported from Mexico and advance protections for consumers in both countries, the U.S. Food and Drug Administration and its regulatory counterparts in Mexico - the Federal Commission for the Protection from Sanitary Risks (Cofepris) and the National Service of Agro-Alimentary Health, Safety and Quality (SENASICA) held the first Food Safety Partnership Annual Meeting on August 20, an important milestone in food safety.

23 Aug 2021

DeepSARS simultaneously detects and conducts genomic surveillance of SARS-CoV-2

A new study discusses the development of DeepSARS, a high-throughput platform for diagnostic detection and genomic surveillance of SARS-CoV-2.

23 Aug 2021

Rare gene variant increases zoonotic H7N9 virus susceptibility in humans

Rare, single-nucleotide variants in the MX1 gene increase human susceptibility to zoonotic H7N9 avian influenza infection, according to a new study.

19 Aug 2021

P681R spike mutation enhances replication efficiency of SARS-CoV-2 delta variant

A team of scientists from the University of Texas, USA, has recently revealed that the P681R spike mutation is responsible for increased infectivity of the delta variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The P681R spike mutation increases the replication of the delta variant by increasing the dissociation of S1 and S2 subunits at the furin cleavage site. The study is currently available on the bioRxiv* preprint server.

18 Aug 2021

New genomic and geological mapping tool may help track the deadliest of foodborne pathogens

Among the deadliest of foodborne pathogens, Listeria monocytogenes soon may become easier to track down in food recalls and other investigations, thanks to a new genomic and geological mapping tool created by Cornell University food scientists.

11 Aug 2021

Whole Genome Sequencing News and Research

New insights could help unlock the mystery of how lung cancer arises in never smokers

Patients who contract SARS-CoV-2 Delta variant more likely to be hospitalized than those with Alpha

Increased evolutionary rates seen in SARS-CoV-2 variants of concern

Studies outlines novel strategies for detecting cancer and minimal residual disease

Liquid biopsies could help identify, track bladder cancer and peripheral nerve tumors

Blood test could enable early detection of cancer in people with neurofibromatosis type 1

Genomic autopsy reveals many genetic variants associated with cardiomyopathy

Anti-SARS-CoV-2 immunity induced by Pfizer/BioNTech vaccine may decline after 6 months

Study compares risk of hospitalization from SARS-CoV-2 delta and alpha variants

Prevalence of vaccine breakthrough cases in SF Bay Area

Could genetic variants in host cell receptors (ACE2) explain COVID-19 susceptibility among certain ethnic groups?

Molecular autopsy of dried blood spots can identify underlying cause of sudden cardiac death in a young person

SARS-CoV-2 alpha variant increased COVID-19 severity in Scotland's 3rd wave

Study on SARS-CoV-2 Delta breakthrough infections shows twice the risk as Alpha

SARS-CoV-2 Delta variant associated with more breakthrough infections

FDA and Mexican counterparts report accomplishments and set goals for future food safety partnership

DeepSARS simultaneously detects and conducts genomic surveillance of SARS-CoV-2

Rare gene variant increases zoonotic H7N9 virus susceptibility in humans

P681R spike mutation enhances replication efficiency of SARS-CoV-2 delta variant

New genomic and geological mapping tool may help track the deadliest of foodborne pathogens

The art of CRISPR: The power and promise of gene editing eBook

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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