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The potential of mRNA vaccines for a wide range of diseases

A new review article published in the journal Briefings in Functional Genomics focuses on the general characteristic features and mechanisms of mRNA vaccines. Further, this review has summarized the current progress of mRNA vaccines that have been developed for wide-ranging diseases, including COVID-19 disease.

8 Jun 2021

How SARS-CoV-2 variant B.1.1.7 adapted to evade innate immunity

Researchers in the United States and the UK have conducted a study showing how the B.1.1.7 (Alpha) lineage of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) adapted to suppress host innate immune responses in lung epithelial cells.

8 Jun 2021

Researchers identify a novel host-directed therapeutic approach to COVID-19

Researchers in the UK have demonstrated the potential of modulating the expression of angiotensin-converting enzyme 2 (ACE2) as a novel host-directed therapeutic approach to protecting against coronavirus disease 2019 (COVID-19).

8 Jun 2021

Specially-designed mindfulness program helps reduce GP trainee burnout

Medics training to become general practitioners reported a significant positive improvement in their mental wellbeing after participating in a specially-designed mindfulness program, a study from University of Warwick researchers shows.

8 Jun 2021

Study reveals personal stigma and discrimination towards people living with HIV

Forty years ago, the first cases of HIV/AIDS in the U.S began to raise public awareness- but new research highlights the struggle people living with the disease still face against stigma, discrimination and negative labeling in their own families, communities and even amongst healthcare professionals.

8 Jun 2021

Cell-to-cell contact helps in spreading SARS-CoV-2, finds study

People aren’t the only ones who should be social distancing — new research shows our cells need to as well. Researchers from Ohio State University in Columbus, Ohio, USA, used in-culture techniques to confirm SARS-CoV-2 transmission via cell-to-cell contact.

8 Jun 2021

NIH researchers find that the SARS-CoV-2 Nsp15’s uridine cleavage can evade the immune response

Research conducted by scientists at the National Institutes of Health in the USA shows that Nsp15 targets uridines (U). Following detection of U, Nsp15 can then further cleave a broad spectrum of RNA substrates.

8 Jun 2021

What lessons have we learned over a year into the COVID-19 pandemic?

One of the pressing questions scientists are currently trying to answer is whether the current vaccines will remain effective against the emerging SARS-CoV-2 variants of concern. A new piece of research has been published in the journal Biomedicines, which discusses the knowledge we have gained thus far and the questions that researchers should address in future work.

8 Jun 2021

Treating critically ill COVID-19 patients with non-altered umbilical cord stem cells increases survival

Critically ill COVID-19 patients treated with non-altered stem cells from umbilical cord connective tissue were more than twice as likely to survive as those who did not have the treatment, according to a study published today in STEM CELLS Translational Medicine.

8 Jun 2021

What is the role of monoclonal antibody therapy in treating COVID-19?

A new study has been published in the journal Vaccines that deals with the present state of research on using mAbs for the treatment of the COVID-19 disease. Many clinical trials are being conducted to evaluate the efficacy and safety of several newly designed mAbs. Some of the mAbs are directed towards immune system responses, i.e., non-SARS-CoV-2 specific mAbs, while others are devised to neutralize the SARS-CoV-2 protein structure, i.e., SARS-CoV-2 specific mAbs.

8 Jun 2021

New measure of heart function could improve survival for people with heart failure

A new physiological measurement of heart function developed at UVA Health could improve survival for people with heart failure by identifying high-risk patients who require tailored treatments, a new study suggests.

8 Jun 2021

With roots in civil rights, Community health centers push for equity in the pandemic

In the 1960s, health care across the Mississippi Delta was sparse and much of it was segregated. Some hospitals were dedicated to Black patients, but they often struggled to stay afloat.

8 Jun 2021

Kidney experts say it’s time to remove race from medical algorithms. Doing so is complicated.

Alphonso Harried recently came across a newspaper clipping about his grandfather receiving his 1,000th dialysis treatment. His grandfather later died — at a dialysis center — as did his uncle, both from kidney disease.

8 Jun 2021

Boeing tested air purifiers like those widely used in schools. It decided not to use them in planes.

Aerospace giant Boeing tested two kinds of ionization technologies — like those widely adopted in schools hoping to combat covid — to determine how well each killed germs on surfaces and decided that neither was effective enough to install on its commercial planes.

8 Jun 2021

Could the intranasal route be an alternate avenue of COVID-19 vaccination?

A new study has been published in the journal Vaccines that summarizes the history of vaccines, reviews the current progress in COVID-19 vaccine technology, and discusses the status of intranasal COVID-19 vaccines as a potential pathway to immunization.

8 Jun 2021

Researchers review environmental risk assessments for recombinant COVID-19 viral vector vaccines

In a recent review, published in the journal Vaccines, researchers in Belgium look at the recombinant viral vector-vaccine candidates that are primarily against SARS-CoV-2 still in development and discuss their features from an environmental risk point of view.

8 Jun 2021

Iksuda Therapeutics closes $47 million financing round

Iksuda Therapeutics (Iksuda) has announced it has completed a US $47 million (circa GB £34 million) financing round, co-led by Mirae Asset Capital and its subsidiaries, Celltrion and Premier Partners, with the Company being advised by Ashfords LLP. The funding will support the advancement of Iksuda’s lead ADC assets and expansion of its payload and conjugation platform technologies.

From Iksuda Therapeutics 8 Jun 2021

Nanozymes to the rescue - potential role in fighting COVID-19

Over the last few decades, researchers have developed artificial enzymes for many applications. Recently, they deployed nanomaterial-based enzyme mimetics or nanozymes in diagnosis and therapeutics. Nanozymes find applications in various biomedical applications, including antiviral agents and cancer therapy.

8 Jun 2021

Immunomodulatory therapies for nephrological autoimmune diseases may help treat severe COVID-19

Various viruses and bacteria have long been known to cause autoimmune diseases where there is such a predisposition. This phenomenon also seems to play a major role in SARS-CoV-2, especially in severe courses.

8 Jun 2021

No point vaccinating those who’ve had COVID-19: Cleveland Clinic study suggests

The study findings reveal that individuals with previous SARS-CoV-2 infection do not get additional benefits from vaccination, indicating that COVID-19 vaccines should be prioritized to individuals without prior infection. The study is currently available on the medRxiv* preprint server.

8 Jun 2021

Research News and Research

The potential of mRNA vaccines for a wide range of diseases

How SARS-CoV-2 variant B.1.1.7 adapted to evade innate immunity

Researchers identify a novel host-directed therapeutic approach to COVID-19

Specially-designed mindfulness program helps reduce GP trainee burnout

Study reveals personal stigma and discrimination towards people living with HIV

Cell-to-cell contact helps in spreading SARS-CoV-2, finds study

NIH researchers find that the SARS-CoV-2 Nsp15’s uridine cleavage can evade the immune response

What lessons have we learned over a year into the COVID-19 pandemic?

Treating critically ill COVID-19 patients with non-altered umbilical cord stem cells increases survival

What is the role of monoclonal antibody therapy in treating COVID-19?

New measure of heart function could improve survival for people with heart failure

With roots in civil rights, Community health centers push for equity in the pandemic

Kidney experts say it’s time to remove race from medical algorithms. Doing so is complicated.

Boeing tested air purifiers like those widely used in schools. It decided not to use them in planes.

Could the intranasal route be an alternate avenue of COVID-19 vaccination?

Researchers review environmental risk assessments for recombinant COVID-19 viral vector vaccines

Iksuda Therapeutics closes $47 million financing round

Nanozymes to the rescue - potential role in fighting COVID-19

Immunomodulatory therapies for nephrological autoimmune diseases may help treat severe COVID-19

No point vaccinating those who’ve had COVID-19: Cleveland Clinic study suggests

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