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Novel lipid-based therapeutic shows promise for combating drug resistance in AML

Researchers at the Medical University of South Carolina Hollings Cancer Center have discovered a mechanism that confers resistance to drugs used to treat certain types of acute myeloid leukemia (AML).

24 Oct 2016

Sanford opens new immunotherapy study on colorectal cancer

Sanford Health has opened another clinical trial exploring the power of the body's immune system to fight cancer.

21 Oct 2016

Rare neurological syndromes linked to variations in ATAD3A gene

A team of scientists from a number of institutions around the world, including Baylor College of Medicine, has discovered that rare neurological syndromes for which there was no cause can be the result of variations in the gene ATAD3A.

21 Oct 2016

Pathology of Krabbe's disease may provide insights on late-onset neurodegenerative diseases

A recent article suggests that an enzyme deficiency seen in the lysosomal storage disorder Krabbe's disease may point to new and contributing mechanisms underlying certain late-onset neurodegenerative diseases such as Parkinson's disease.

21 Oct 2016

Scientists suggest potential approach of lowering tau levels to thwart Alzheimer's disease

Taking a pill that prevents the accumulation of toxic molecules in the brain might someday help prevent or delay Alzheimer's disease, according to scientists at Baylor College of Medicine, Texas Children's Hospital and Johns Hopkins University School of Medicine.

21 Oct 2016

Researchers discover how toxic proteins linked to neurological diseases impair membrane-less organelles

Researchers at St. Jude Children's Research Hospital have discovered the way toxic proteins linked to the most common forms of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) incapacitate membrane-less organelles inside cells.

21 Oct 2016

Study shows how damage to RNA-binding protein contributes to ALS

Although only 10 percent of amyotrophic lateral sclerosis (ALS) cases are hereditary, a significant number of them are caused by mutations that affect proteins that bind RNA, a type of genetic material.

21 Oct 2016

UCSF researchers find active HIV in tissue samples of patients treated with antiretrovirals

While successful treatment of HIV with antiretroviral medications leads to undetectable levels of virus in the blood, controls the disease and leads to much longer lifespans, scientists know that HIV continues to reside in tissues.

21 Oct 2016

Targeting TASINs can be viable approach for preventing colon cancer, research reveals

A small molecule called TASIN-1 can selectively kill cells with a mutation that is considered to be a precursor to colon cancer, while sparing related normal cells, UT Southwestern Medical Center cancer biologists have demonstrated.

20 Oct 2016

New method provides cost-effective way to effectively diagnose genetic forms of high-cholesterol

A new genetic testing method developed at Western University called LipidSeq can identify a genetic basis for high-cholesterol in almost 70 per cent of a targeted patient population.

20 Oct 2016

Scientists use male mice model to study how genes affect sequencing of vocal sounds

There's a particular order to the sounds of the ultrasonic song a male mouse performs to impress his potential mate.

20 Oct 2016

Gene variants linked to hot flashes in menopausal women

Most women experience hot flashes and night sweats either before or during menopause, but a significant minority don't have these symptoms. Could our genes be a factor in determining which women get hot flashes?

19 Oct 2016

Network of proteins linked to cancer may play vital role in male fertility

Researchers studying reproductive science identified a network of proteins often linked to cancer as also important to male fertility and the birth of healthy offspring, according to a study in the Oct. 18 online issue of Cell Reports.

19 Oct 2016

IBM, Quest Diagnostics launch new genomic tumor sequencing service to help advance precision medicine

IBM Watson Health and Quest Diagnostics today announced the launch of IBM Watson Genomics from Quest Diagnostics, a new service that helps advance precision medicine by combining cognitive computing with genomic tumor sequencing.

From Quest Diagnostics 19 Oct 2016

Chemotherapy leads to drug-resistance in bladder cancer patients

Chemotherapy is indicated as the first line of treatment for advanced bladder cancer. New research by Weill Cornell Medicine and University of Trento scientists shows that while chemotherapy kills the most common type of bladder cancer, urothelial cancer, chemotherapy also shapes the genetic evolution of remaining urothelial cancer cell clones to become drug-resistant.

18 Oct 2016

Blood tests may decrease wait time between diagnosis and treatment of lung cancer

A study from Gundersen Health System, La Crosse, Wisconsin, reveals to the value of blood-based genomic and proteomic testing in patients with lung cancer at the time of initial diagnoses.

18 Oct 2016

Penn researchers identify new immune system mechanism to fight against infections

The innate immune system serves as a first-line defense, responding to infections almost immediately after a pathogen makes its way into the body.

17 Oct 2016

Researchers develop MRI-based method that can track progression of genetically mutated gliomas

UT Southwestern Medical Center researchers have developed an MRI-based method that can track the state and progression of a common type of genetically mutated brain cancer.

17 Oct 2016

Icelandic people more likely to carry novel rare genetic variant linked to risk of Alzheimer's disease

People with Icelandic heritage are more likely to carry a novel rare mutation in the TM2D3 gene, which leads to greater risk for Alzheimer's disease, based on a new study published October 14th, 2016 in PLOS Genetics by Johanna Jakobsdottir of the Icelandic Heart Association, Sven van der Lee of Erasmus University in Rotterdam, and colleagues.

17 Oct 2016

Immune system plays important role in Duchenne muscular dystrophy, research reveals

A new paper, co-written by faculty at Binghamton University, State University of New York, increases the understanding of Duchenne muscular dystrophy (DMD)—one of the most common lethal genetic disorders—and points to potential therapeutic approaches.

14 Oct 2016

Mutation News and Research

Novel lipid-based therapeutic shows promise for combating drug resistance in AML

Sanford opens new immunotherapy study on colorectal cancer

Rare neurological syndromes linked to variations in ATAD3A gene

Pathology of Krabbe's disease may provide insights on late-onset neurodegenerative diseases

Scientists suggest potential approach of lowering tau levels to thwart Alzheimer's disease

Researchers discover how toxic proteins linked to neurological diseases impair membrane-less organelles

Study shows how damage to RNA-binding protein contributes to ALS

UCSF researchers find active HIV in tissue samples of patients treated with antiretrovirals

Targeting TASINs can be viable approach for preventing colon cancer, research reveals

New method provides cost-effective way to effectively diagnose genetic forms of high-cholesterol

Scientists use male mice model to study how genes affect sequencing of vocal sounds

Gene variants linked to hot flashes in menopausal women

Network of proteins linked to cancer may play vital role in male fertility

IBM, Quest Diagnostics launch new genomic tumor sequencing service to help advance precision medicine

Chemotherapy leads to drug-resistance in bladder cancer patients

Blood tests may decrease wait time between diagnosis and treatment of lung cancer

Penn researchers identify new immune system mechanism to fight against infections

Researchers develop MRI-based method that can track progression of genetically mutated gliomas

Icelandic people more likely to carry novel rare genetic variant linked to risk of Alzheimer's disease

Immune system plays important role in Duchenne muscular dystrophy, research reveals

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