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Cleveland Clinic cancer researchers receive $2.4 million grant from NIH NHLBI

The National Institutes of Health National Heart, Lung and Blood Institute has awarded a $2.4 million grant over four years to Cleveland Clinic cancer researchers Jaroslaw Maciejewski, M.D., and Richard Padgett, Ph.D., to test the hypothesis that alterations in the pattern of splicing of target genes play a major role in the establishment or progression of myelodysplastic syndromes (MDS).

14 Oct 2016

Study provides insights into how species adapt to changing environments over many generations

Research led by the European Bioinformatics Institute and the University of Washington has shown that the biological diversity needed for evolution can be generated by changes in protein modifications.

14 Oct 2016

Discovery of neuropilin 2 deficiency may lead to new therapies for edema and lymphedema

Fluid accumulation and swelling (edema) may result from the malfunctioning of regulatory processes controlling vessel permeability in the body.

14 Oct 2016

Researchers develop mouse model to investigate behavioral effects of eating disorder gene

Giving mice a gene mutation linked to eating disorders in people causes feeding and behavior abnormalities similar to symptoms often seen in patients with eating disorders. Only female mice are affected by the gene mutation, and some of the abnormalities in the female mice depend on whether they are housed alone or together with other mice.

13 Oct 2016

Penn researchers receive $5.2 million NIH grant to study mechanisms that promote lung regeneration

Penn Medicine researchers, along with colleagues at Cincinnati Children's Hospital and Boston University, have received a $5.2 million, seven-year grant from the National Heart, Lung, and Blood Institute of the National Institutes of Health to study the cellular and molecular mechanisms that promote lung regeneration.

13 Oct 2016

Depriving deadly brain cancer cells of cholesterol causes tumor regression in mouse models

Researchers at University of California San Diego School of Medicine, Ludwig Institute for Cancer Research and The Scripps Research Institute, with colleagues in Los Angeles and Japan, report that depriving deadly brain cancer cells of cholesterol, which they import from neighboring healthy cells, specifically kills tumor cells and caused tumor regression and prolonged survival in mouse models.

13 Oct 2016

U of A researchers to study origin of Leigh's disease

Researchers at the University of Arkansas and their collaborators will use a $1.4 million grant from the U.S. Department of Defense to study the origin of Leigh's disease, a rare and incurable disease that affects the central nervous system.

13 Oct 2016

Genome engineering-based methods pave way for new treatment of patients with sickle cell disease

A team of physicians and laboratory scientists has taken a key step toward a cure for sickle cell disease, using CRISPR-Cas9 gene editing to fix the mutated gene responsible for the disease in stem cells from the blood of affected patients.

12 Oct 2016

Researchers identify how amyloid beta linked to Alzheimer's disease could trigger Parkinson's

Alzheimer's and Parkinson's diseases are different neurodegenerative conditions that can sometimes affect the same person, which has led scientists to investigate possible links between the two.

12 Oct 2016

Yale researchers define genetic landscape of rare, aggressive carcinosarcomas

In a major breakthrough for ovarian and uterine cancers, Yale researchers have defined the genetic landscape of rare, highly aggressive tumors called carcinosarcomas (CSs), pointing the way to possible new treatments.

12 Oct 2016

Biomedical researchers develop new RNA ligase for laboratory use

Ligases are enzymes that serve critical functions in cells, helping to fuse together broken strands of DNA and RNA. These enzymes are also important bioengineering tools, useful in genetic sequencing, mutation detection and other applications.

12 Oct 2016

Researchers describe novel host-oriented therapeutic approach for preventing lethal immune responses

Staphylococcal and streptococcal infections affect millions of individuals each year. They are a leading cause of sepsis and account for many cases of pneumonia and post-surgical infections.

8 Oct 2016

PARP inhibitor prolongs progression-free survival in patients with recurrent ovarian cancer

The PARP inhibitor niraparib significantly improves the outcome of platinum-sensitive recurrent ovarian cancer, according to full data from the ENGOT-OV16/NOVA trial presented for the first time at the ESMO 2016 Congress in Copenhagen and published in the New England Journal of Medicine.

8 Oct 2016

Study finds new therapeutic target to prevent progression of rare blood cancer

In a laboratory study, Upstate Medical University researcher Golam Mohi, Ph.D., his graduate student Yue Yang, and colleagues, have found that the loss of gene EZH2 promotes the development of Myelofibrosis (MF) in mice.

7 Oct 2016

Researchers uncover disruption of stress-coping mechanism in Parkinson's disease

Leading-edge research by the team of professor Patrik Verstreken has shown for the first time that a malfunctioning stress-coping mechanism in the brain is at the root of Parkinson's disease.

7 Oct 2016

Diamond publishes milestone paper that reveals discovery of genetic triggers behind birth defects

Researchers at the UK's national synchrotron facility, Diamond Light Source, have just published the 5000th scientific paper using data from the facility. This milestone marks a significant step for the synchrotron that is used by over 8,000 scientists each year.

7 Oct 2016

Researchers explain why explain why some tumors recur after immunotherapy

Immunotherapy is a new and highly promising form of treatment for cancer. In many patients, however, tumors recur after immunotherapy.

7 Oct 2016

Researchers to explore potential roles of tumor-suppressor gene in kidney cancer

Renal cell carcinoma is the most common type of kidney cancer, and African-Americans and males appear most at risk for this disease that can be asymptomatic until it has spread and become highly lethal, said Dr. Vinata B. Lokeshwar, cancer researcher and chair of the Department of Biochemistry and Molecular Biology at the Medical College of Georgia at Augusta University.

7 Oct 2016

Researchers report high response rate with single drug in phase I/II trial of paediatric brain cancer

A high response rate with a single drug in a phase I/II trial of paediatric brain tumour has set the stage for combination therapy with higher response and lower toxicity, researchers reported at the ESMO 2016 Congress in Copenhagen.

7 Oct 2016

Study finds neoadjuvant immunotherapy safe, viable for early lung cancer patients before surgery

Neoadjuvant immunotherapy with the PD-1 inhibitor nivolumab is safe and feasible prior to surgery for early lung cancer, researchers reported at the ESMO 2016 Congress in Copenhagen.

7 Oct 2016

Mutation News and Research

Cleveland Clinic cancer researchers receive $2.4 million grant from NIH NHLBI

Study provides insights into how species adapt to changing environments over many generations

Discovery of neuropilin 2 deficiency may lead to new therapies for edema and lymphedema

Researchers develop mouse model to investigate behavioral effects of eating disorder gene

Penn researchers receive $5.2 million NIH grant to study mechanisms that promote lung regeneration

Depriving deadly brain cancer cells of cholesterol causes tumor regression in mouse models

U of A researchers to study origin of Leigh's disease

Genome engineering-based methods pave way for new treatment of patients with sickle cell disease

Researchers identify how amyloid beta linked to Alzheimer's disease could trigger Parkinson's

Yale researchers define genetic landscape of rare, aggressive carcinosarcomas

Biomedical researchers develop new RNA ligase for laboratory use

Researchers describe novel host-oriented therapeutic approach for preventing lethal immune responses

PARP inhibitor prolongs progression-free survival in patients with recurrent ovarian cancer

Study finds new therapeutic target to prevent progression of rare blood cancer

Researchers uncover disruption of stress-coping mechanism in Parkinson's disease

Diamond publishes milestone paper that reveals discovery of genetic triggers behind birth defects

Researchers explain why explain why some tumors recur after immunotherapy

Researchers to explore potential roles of tumor-suppressor gene in kidney cancer

Researchers report high response rate with single drug in phase I/II trial of paediatric brain cancer

Study finds neoadjuvant immunotherapy safe, viable for early lung cancer patients before surgery

Improving healthcare sustainability through carbon data

Managing vibration in IVF laboratories

A New Approach to Preventing Bladder Cancer Recurrence

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