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Researchers investigate immune molecule that helps protect transplanted kidneys

Looking to improve organ transplant success, researchers are working to learn more about how an immune molecule, which also protects a fetus, helps protect some transplanted kidneys, and to develop a synthetic version of that molecule that could help more patients.

18 May 2021

Study: No major difference in mortality between patients treated with drug-coated and non-drug-coated devices

Peripheral artery disease (PAD), or blockages in the arteries outside of the heart, affects more than 200 million people worldwide and 12.5 million people in the United States. Patients with this circulatory disorder may develop severe leg pain or unhealing wounds that require a minimally invasive revascularization procedure to open the blood vessels to improve blood flow.

18 May 2021

New method can predict suicide risk

A team of Welsh academics has developed a new method of supporting health professionals to make clinical decisions about people who may be at risk of taking their own lives.

18 May 2021

Type of heart failure may influence which approach is optimal for patients with AFib

Among patients with both heart failure and atrial fibrillation (AFib), treatment strategies focused on controlling the heart rhythm (using catheter ablation) and those focused on controlling the heart rate (using drugs and/or a pacemaker) showed no significant differences in terms of death from any cause or progression of heart failure.

18 May 2021

Study shows how biases could be perpetuated by AI devices

Clinicians and surgeons are increasingly using medical devices based on artificial intelligence. These AI devices, which rely on data-driven algorithms to inform health care decisions, presently aid in diagnosing cancers, heart conditions and diseases of the eye, with many more applications on the way.

18 May 2021

A promising drug delivery system for therapeutics that shut down harmful genes

Viruses attack the body by sending their genetic code -- DNA and RNA -- into cells and multiplying. A promising class of therapeutics that uses synthetic nucleic acids to target and shut down specific, harmful genes and prevent viruses from spreading is gaining steam.

18 May 2021

Stabilizing mutations in SARS-CoV-2 immunogens improve vaccine design

Researchers in the United States have developed stabilized immunogens presenting the receptor-binding domain (RBD) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that may improve the scalability of RBD-based coronavirus vaccines.

18 May 2021

Stair-climbing routines provide cardiovascular and muscular benefits to heart patients

A team of McMaster University researchers who studied heart patients found that stair-climbing routines, whether vigorous or moderate, provide significant cardiovascular and muscular benefits.

18 May 2021

Sperm deliver signals to female reproductive tissues to increase the chances of conception

Sperm are generally viewed as having just one action in reproduction - to fertilize the female's egg - but studies at the University of Adelaide are overturning that view.

18 May 2021

Sotagliflozin reduces adverse cardiovascular events across patients with diabetes, heart failure

Patients with both diabetes and heart failure who were treated with sotagliflozin, a novel investigational drug for diabetes, for a median of nine to 16 months experienced reductions of 22% to 43% in the risk of death or worsening heart failure compared with similar patients who were treated with a placebo

18 May 2021

Dendritic cells can take a shortcut to reach the lymph nodes more quickly

In its response to pathogens and vaccines, our immune system relies on dendritic cells. These white blood cells patrol the body's tissues, collect components of pathogens and vaccines and transport them via lymphatic vessels to the nearest lymph node.

18 May 2021

Abnormal blood levels of proteins linked to dementia, Alzheimer's disease

The development of dementia, often from Alzheimer's disease, late in life is associated with abnormal blood levels of dozens of proteins up to five years earlier, according to a new study led by researchers at the Johns Hopkins Bloomberg School of Public Health

18 May 2021

Milder COVID-19 in children may be due to higher memory B cells responses to SARS-CoV-2

A new research paper published in the journal Science explores the differences in coronavirus-specific B memory cell repertoires in children versus adults, as well as the functional importance of this discovery.

18 May 2021

A potential treatment to prevent obesity-related liver damage

One of the especially dangerous health risks of being extremely overweight occurs when an obese person begins to accumulate fat in their liver.

18 May 2021

Pirfenidone significantly reduces a marker of heart muscle scarring

Patients with heart failure with preserved ejection fraction who took the antifibrotic drug pirfenidone saw a significant reduction in a marker of heart muscle scarring compared with patients who received a placebo, based on findings from an early-phase trial presented at the American College of Cardiology's 70th Annual Scientific Session.

18 May 2021

Omecamtiv mecarbil significantly reduces hospitalizations among patients with severe heart failure

The experimental heart failure drug omecamtiv mecarbil reduced heart failure hospitalizations by a greater margin among patients with more severely reduced ejection fraction, a measure indicating severe impairment in the heart's pumping ability, compared with those who had moderately reduced ejection fraction, according to research presented at the American College of Cardiology's 70th Annual Scientific Session.

18 May 2021

New technology tricks tumors to eliminate itself through the production of anti-cancer agents

Scientists at the University of Zurich have modified a common respiratory virus, called adenovirus, to act like a Trojan horse to deliver genes for cancer therapeutics directly into tumor cells. Unlike chemotherapy or radiotherapy, this approach does no harm to normal healthy cells.

18 May 2021

Preoperative testing is often unnecessary for low-risk surgeries, shows study

Before undergoing surgery, patients often go through a number of tests: blood work, sometimes a chest X-ray, perhaps tests to measure heart and lung function.

18 May 2021

New review questions the validity of research on the impact of screen time on mental health

University researchers have carried out the largest systematic review and meta-analysis to date of how people's perceptions of their screen time compare with what they do in practice, finding estimates of usage were only accurate in about five per cent of studies.

18 May 2021

Researchers receive $4.5 million grant to improve quality of care for people with cardiovascular disease

Researchers from the University of Tennessee Health Science Center have received a $4.5 million grant over three years from the Agency for Healthcare Research and Quality (AHRQ) to lead a statewide network of primary care providers, health systems, and academic centers to identify, develop, and implement patient-centered approaches to improve quality of care and outcomes for people with cardiovascular disease.

18 May 2021

Research News and Research

Researchers investigate immune molecule that helps protect transplanted kidneys

Study: No major difference in mortality between patients treated with drug-coated and non-drug-coated devices

New method can predict suicide risk

Type of heart failure may influence which approach is optimal for patients with AFib

Study shows how biases could be perpetuated by AI devices

A promising drug delivery system for therapeutics that shut down harmful genes

Stabilizing mutations in SARS-CoV-2 immunogens improve vaccine design

Stair-climbing routines provide cardiovascular and muscular benefits to heart patients

Sperm deliver signals to female reproductive tissues to increase the chances of conception

Sotagliflozin reduces adverse cardiovascular events across patients with diabetes, heart failure

Dendritic cells can take a shortcut to reach the lymph nodes more quickly

Abnormal blood levels of proteins linked to dementia, Alzheimer's disease

Milder COVID-19 in children may be due to higher memory B cells responses to SARS-CoV-2

A potential treatment to prevent obesity-related liver damage

Pirfenidone significantly reduces a marker of heart muscle scarring

Omecamtiv mecarbil significantly reduces hospitalizations among patients with severe heart failure

New technology tricks tumors to eliminate itself through the production of anti-cancer agents

Preoperative testing is often unnecessary for low-risk surgeries, shows study

New review questions the validity of research on the impact of screen time on mental health

Researchers receive $4.5 million grant to improve quality of care for people with cardiovascular disease

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