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Pitt researchers show how repair protein finds structural errors in DNA

Researchers at the University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute have demonstrated how Rad4, a protein involved in DNA repair, scans the DNA in a unique pattern of movement called "constrained motion" to efficiently find structural faults in DNA.

7 Oct 2016

Combination therapy for melanoma has added benefit in certain patients

Nivolumab in combination with ipilimumab has been approved since May 2016 for adults with advanced melanoma. The German Institute for Quality and Efficiency in Health Care examined in a dossier assessment whether this drug offers an added benefit.

6 Oct 2016

New study finds no evidence of benefit from genetic disposition of eczema

Some genetic diseases persist for generation after generation because the genes that cause them can benefit human health.

6 Oct 2016

Japanese researchers discover causative gene for common type of hearing loss

A causative gene for a highly common type of hearing loss (sensorineural hearing loss, or SNHL) has been identified by a group of Japanese researchers, who successfully replicated the condition using a transgenic mouse.

6 Oct 2016

BGU researchers move one step closer to understanding genes linked to autism

Ben-Gurion University of the Negev researchers are a step closer to understanding the genetic basis of autism, which they hope will lead to earlier diagnosis of what is rapidly becoming the most prevalent developmental disorder worldwide.

6 Oct 2016

Treatment using PARP inhibitor shrinks tumors in breast cancer patients with BRCA mutations

All 13 newly diagnosed breast cancer patients with BRCA mutations had their tumors shrink significantly when treated with a PARP inhibitor ahead of frontline presurgical chemotherapy in a pilot study at The University of Texas MD Anderson Cancer Center.

5 Oct 2016

Researchers aim to stop breast cancer metastasis from happening altogether

A new Tel Aviv University study finds that combining genetic therapy with chemotherapy delivered to a primary tumor site is extremely effective in preventing breast cancer metastasis.

5 Oct 2016

Professor Illana Gozes from Tel Aviv University receives 2016 RARE Champion of Hope award

Tel Aviv University's Prof. Illana Gozes was awarded the 2016 RARE Champion of Hope -- Science International Prize by Global Genes, a leading global advocacy non-profit organization for patients and families fighting rare and genetic diseases.

5 Oct 2016

Researchers identify new strategy to selectively sensitize cancer cells to radiation therapy

Many types of cancer become drug resistant, making them difficult to treat. Researchers with University of California San Diego School of Medicine and Moores Cancer Center have identified a strategy to selectively sensitize certain cancer cells to radiation therapy that may improve tumor control and reduce treatment-related side effects.

5 Oct 2016

Prion proteins can drive emergence of new traits and adaptive opportunities

Prion proteins, best known as the agents of deadly brain disorders like mad cow disease, can help yeast survive hard times and pass the advantageous traits down to their offspring, according to a new study by researchers at the Stanford University School of Medicine.

4 Oct 2016

Discovery of rare flu-thwarting mutation could provide new strategy for live influenza vaccines

A rare and improbable mutation in a protein encoded by an influenza virus renders the virus defenseless against the body's immune system. This University of Rochester Medical Center discovery could provide a new strategy for live influenza vaccines in the future.

4 Oct 2016

BUSM scientists discover new strategy to treat colon cancers driven by mutant KRAS genes

Researchers from Boston University School of Medicine have discovered a possible strategy to treat colon cancers that are caused by the mutant KRAS gene, which is responsible for approximately half of all colon cancer cases.

4 Oct 2016

UTA research opens new doors for treatment of autoimmune diseases

Biologists at The University of Texas at Arlington have demonstrated that removing water molecules can deactivate caspase-3 enzymes, which opens new doors for treatment of autoimmune diseases like arthritis, which have been linked to overactive enzymes.

4 Oct 2016

Mutation News and Research

Pitt researchers show how repair protein finds structural errors in DNA

Combination therapy for melanoma has added benefit in certain patients

New study finds no evidence of benefit from genetic disposition of eczema

Japanese researchers discover causative gene for common type of hearing loss

BGU researchers move one step closer to understanding genes linked to autism

Treatment using PARP inhibitor shrinks tumors in breast cancer patients with BRCA mutations

Researchers aim to stop breast cancer metastasis from happening altogether

Professor Illana Gozes from Tel Aviv University receives 2016 RARE Champion of Hope award

Researchers identify new strategy to selectively sensitize cancer cells to radiation therapy

Prion proteins can drive emergence of new traits and adaptive opportunities

Discovery of rare flu-thwarting mutation could provide new strategy for live influenza vaccines

BUSM scientists discover new strategy to treat colon cancers driven by mutant KRAS genes

UTA research opens new doors for treatment of autoimmune diseases

Study identifies prognostic value of IDH and CIC mutations for grade II/III glioma patients

BGU researchers elucidate molecular mechanism that could lead to new therapies for ALS

Study suggests targeting UNG enzyme may help treat non-Hodgkin's lymphoma

Study finds potential therapeutic target for KRAS-driven cancers

Research shows how new ovarian cancer treatment could help boost anti-tumor immunity

New study reveals CAR T cells can function as micro-pharmacies for precise therapeutic delivery

Researchers move one step closer to unraveling mechanism of multiple-gene disorder

Improving healthcare sustainability through carbon data

Managing vibration in IVF laboratories

A New Approach to Preventing Bladder Cancer Recurrence

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