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Biomechanical model simulates breast tumor growth

Scientists from Universidad Carlos III de Madrid (UC3M) and Johns Hopkins University (JHU), in the USA, have analyzed the growth of breast tumors from a biomechanical perspective and have created a computational model that simulates the invasion process of cancer cells, depending on the characteristics of the surrounding tissue and cell junctions, among other parameters.

21 Mar 2024

New AI system can be used to reliably detect cardiac amyloidosis

Cardiac amyloidosis is a serious disease in which abnormal proteins (amyloids) accumulate in the heart muscle and impair heart function.

21 Mar 2024

Advancing precision personalized medicine for gastric cancer with 3D bioprinting

Gastric cancer ranks among the most widespread diseases in Asian populations, with South Koreans experiencing the third-highest incidence globally in 2020, as reported by the International Agency for Research on Cancer.

21 Mar 2024

Concomitant pharmacotherapy overcomes immunotherapy challenges in aggressive blood cancer

Researchers at the University of Zurich and the University Hospital Zurich have discovered that a specific mutation in the cancer cells of an aggressive type of blood cancer can prevent novel immunotherapies such as CAR T-cell therapy from working.

21 Mar 2024

From farm to pharmacy: Transgenic cow milk as a new source of human insulin

A team of researchers from Brazil constructed a lentivirus vector with expression specific for mammary glands and carrying the gene for human insulin.

21 Mar 2024

Investigational gene therapy shows promise for rare childhood neurodegenerative disease

An investigational gene therapy for a rare neurodegenerative disease that begins in early childhood, known as giant axonal neuropathy (GAN), was well tolerated and showed signs of therapeutic benefit in a clinical trial led by the National Institutes of Health.

20 Mar 2024

Special drug-pricing program boosts prostate cancer treatment adherence

Prostate cancer patients receiving care at hospitals that are part of a special drug-pricing program were more likely to stick to their prescription drug therapy than patients at other hospitals, according to a study from researchers at the University of Michigan's Rogel Cancer Center and Institute for Healthcare Policy and Innovation.

20 Mar 2024

Second-hand vape smoke linked to more asthma symptoms in kids

Study in the journal Children explored the impact of second-hand e-cigarette smoke on children with asthma, suggesting increased symptomatic days despite no significant difference in clinical intervention needs, underscoring the importance of awareness about e-cigarette smoke's potential harms.

20 Mar 2024

Treatment for anxiety and depression associated with improved heart disease outcomes

Treating anxiety and depression reduced emergency room visits and rehospitalizations among people with heart disease, according to new research published today in the Journal of the American Heart Association, an open access, peer-reviewed journal of the American Heart Association.

20 Mar 2024

Hearing loss linked to accelerated Alzheimer's progression via GDF1 pathway

Study unveils the GDF1 signaling pathway's role in mitigating the adverse effects of hearing loss on Alzheimer's disease, spotlighting potential avenues for therapeutic development.

20 Mar 2024

New treatment approach improves recurrence-free survival in early breast cancer patients

A new treatment approach that combines a targeted therapy drug with hormone therapy significantly increased the amount of time a person with stage 2 or 3 HR-positive, HER2-negative early breast cancer lives without the cancer returning, according to a new study co-led by UCLA Health Jonsson Comprehensive Cancer Center investigators.

20 Mar 2024

Microneedles offer a promising solution for the treatment of diabetic wounds

The global population of patients with diabetic wounds is expected to rise to between 9.1 million to 26.1 million by 2030.

20 Mar 2024

Pembrolizumab enhances breast cancer treatment regardless of age or menopausal status

New data from the KEYNOTE-756 phase 3 clinical trial show that adding the immunotherapy drug, pembrolizumab, to chemotherapy before and after surgery for breast cancer leads to better outcomes for patients regardless of their age or menopausal status.

20 Mar 2024

Cryoablation could be a new treatment path for breast cancer patients with large tumors

A minimally invasive technique that uses ice to freeze and destroy small, cancerous tumors has now been proven effective for breast cancer patients with large tumors, providing a new treatment path for those who are not candidates for surgery, according to new research to be presented at the Society of Interventional Radiology Annual Scientific Meeting in Salt Lake City.

20 Mar 2024

Study highlights causal associations between gut microbes and hypothyroidism

The association between the microbial community of the gut and hypothyroidism.

20 Mar 2024

Metformin boosts appetite-suppressing metabolite, new study finds

Metformin treatment boosts levels of Lac-Phe, an appetite-suppressing metabolite, potentially offering new insights into its mechanism and opening doors for obesity treatments.

19 Mar 2024

Tracking circulating tumor DNA could indicate gastroesophageal cancer treatment response

Monitoring levels of DNA shed by tumors and circulating in the bloodstream could help doctors accurately assess how gastroesophageal cancers are responding to treatment, and potentially predict future prognosis, suggests a new study led by researchers at the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy.

19 Mar 2024

MRI and lumbar puncture may not be necessary for managing CAR T-cell associated toxicities

Magnetic resonance imaging (MRI) and lumbar puncture (LP) may not always be necessary for diagnosing and managing a serious neurological complication associated with CAR T-cell therapy, according to a new Blood Advances study.

19 Mar 2024

Developing mRNA lipid nanoparticles for treating oral squamous cell carcinoma

A study aiming to develop a Lipid nanoparticles (LNP) platform for treating oral squamous cell carcinoma (OSCC) utilizing p53 mRNA was presented at the 102nd General Session of the IADR, which was held in conjunction with the 53rd Annual Meeting of the American Association for Dental, Oral, and Craniofacial Research and the 48th Annual Meeting of the Canadian Association for Dental Research, on March 13-16, 2024, in New Orleans, LA, USA.

19 Mar 2024

Osteoporosis model rats show improved healing with FGF-2 treatment

A study investigating the effects of local application of fibroblast growth factor (FGF-2) on periodontal healing in osteoporosis model rats was presented at the 102nd General Session of the IADR, which was held in conjunction with the 53rd Annual Meeting of the American Association for Dental, Oral, and Craniofacial Research and the 48th Annual Meeting of the Canadian Association for Dental Research, on March 13-16, 2024, in New Orleans, LA, USA.

19 Mar 2024

Therapy News and Research

Biomechanical model simulates breast tumor growth

New AI system can be used to reliably detect cardiac amyloidosis

Advancing precision personalized medicine for gastric cancer with 3D bioprinting

Concomitant pharmacotherapy overcomes immunotherapy challenges in aggressive blood cancer

From farm to pharmacy: Transgenic cow milk as a new source of human insulin

Investigational gene therapy shows promise for rare childhood neurodegenerative disease

Special drug-pricing program boosts prostate cancer treatment adherence

Second-hand vape smoke linked to more asthma symptoms in kids

Treatment for anxiety and depression associated with improved heart disease outcomes

Hearing loss linked to accelerated Alzheimer's progression via GDF1 pathway

New treatment approach improves recurrence-free survival in early breast cancer patients

Microneedles offer a promising solution for the treatment of diabetic wounds

Pembrolizumab enhances breast cancer treatment regardless of age or menopausal status

Cryoablation could be a new treatment path for breast cancer patients with large tumors

Study highlights causal associations between gut microbes and hypothyroidism

Metformin boosts appetite-suppressing metabolite, new study finds

Tracking circulating tumor DNA could indicate gastroesophageal cancer treatment response

MRI and lumbar puncture may not be necessary for managing CAR T-cell associated toxicities

Developing mRNA lipid nanoparticles for treating oral squamous cell carcinoma

Osteoporosis model rats show improved healing with FGF-2 treatment

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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