Induced Pluripotent Stem Cells News and Research

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Researchers use stem cells to model different genetic scenarios that underlie neurologic disease

Researchers at Case Western Reserve University School of Medicine have successfully grown stem cells from children with a devastating neurological disease to help explain how different genetic backgrounds can cause common symptoms.

30 Mar 2017

Breakthrough technique harvests stem cells from urine to study Down syndrome

One of the biggest challenges in studying Down syndrome is finding the right research model. Animals and established cell lines are limited in their ability to mimic human disease, and results don't always translate to patient populations.

28 Mar 2017

Multipronged study of schizophrenia-associated syndrome receives $3.1 million NIH grant

A research team at Emory University is embarking on a multipronged study of 3q29 deletion syndrome, a genetic mutation associated with a 40-fold increased risk for schizophrenia and a range of other neuropsychiatric conditions including mild to moderate intellectual disability, autism and anxiety.

24 Mar 2017

Early treatment with stem cells can safely help recovery in stroke patients, study shows

A multicenter trial looking at whether a single dose of millions of adult, bone-marrow-derived stem cells can aid stroke recovery indicates it's safe and well-tolerated by patients but may not significantly improve their recovery within the first three months, researchers report.

20 Mar 2017

UB research yields neural crest cells from adult skin cells without genetic modification

A discovery, several years in the making, by a University at Buffalo research team has proven that adult skin cells can be converted into neural crest cells (a type of stem cell) without any genetic modification, and that these stem cells can yield other cells that are present in the spinal cord and the brain.

15 Mar 2017

LCSB researchers identify how the body influences differentiation of progenitor cells

Stem cells are unspecialised cells that can develop into any type of cell in the human body. So far, however, scientists only partially understand how the body controls the fate of these all-rounders, and what factors decide whether a stem cell will differentiate, for example, into a blood, liver or nerve cell.

15 Mar 2017

Scientists create first model of anorexia nervosa using iPSCs derived from adolescent females

An international research team, led by scientists at University of California San Diego School of Medicine, has created the first cellular model of anorexia nervosa (AN), reprogramming induced pluripotent stem cells (iPSCs) derived from adolescent females with the eating disorder.

14 Mar 2017

New study shows how activation of innate immunity promotes tissue regeneration

Houston Methodist researchers have identified an immune pathway that promotes the formation of a cell that can develop into new tissues and organs.

9 Mar 2017

New progeria-on-a-chip model provides better understanding of vascular disease and aging

Hutchinson-Gilford progeria syndrome is an extremely rare genetic condition that causes premature and accelerated aging.

3 Mar 2017

Scientists gain new insight into early brain pathology of schizophrenia using adult skin cells

The skin cells of four adults with schizophrenia have provided an unprecedented "window" into how the disease began while they were still in the womb, according to a recent paper in Schizophrenia Research.

27 Feb 2017

Researchers develop novel in vivo model for studying pancreatic cancer

Researchers at Okayama University report in the December 2016 issue of the American Journal of Cancer Research a novel in vivo model for the study of pancreatic ductal adenocarcinoma (PDAC) tumors.

21 Feb 2017

Researchers create novel model that reveals cellular, molecular events driving leukemia progression

Mount Sinai researchers have created a novel model that shows the step-by-step progression from normal blood cells to leukemia and its precursor diseases, creating replicas of the stages of the disease to test the efficacy of therapeutic interventions at each stage, according to a study to be published in Cell Stem Cell.

16 Feb 2017

Study suggests that iPSCs do not develop more mutations than subcloned cells

It's been more than 10 years since Japanese researchers Shinya Yamanaka, M.D., Ph.D., and his graduate student Kazutoshi Takahashi, Ph.D., developed the breakthrough technique to return any adult cell to its earliest stage of development (a pluripotent stem cell) and change it into different types of cells in the body.

8 Feb 2017

TSRI study offers first look at early stages of brain development in patients with Fragile X syndrome

A new study led by scientists at The Scripps Research Institute is giving researchers a first look at the early stages of brain development in patients with Fragile X syndrome, a disorder that causes mild to severe intellectual disability and is the most common genetic cause of autism spectrum disorder.

31 Jan 2017

Tissue engineering advance can be important step towards preventing heart failure after heart attack

Researchers have grown heart tissue by seeding a mix of human cells onto a 1-micron-resolution scaffold made with a 3-D printer.

28 Jan 2017

Cellectricon, Censo Biotechnologies launch joint technology access program to accelerate CNS and pain research

Cellectricon AB and Censo Biotechnologies Ltdare announcing the introduction of a joint technology access program for a fully humanized phenotypic screening platform targeting preclinical neuroscience and chronic pain research.

28 Jan 2017

Johns Hopkins researchers create mature cardiomyocytes in the laboratory from stem cells

Generating mature and viable heart muscle cells from human or other animal stem cells has proven difficult for biologists.

26 Jan 2017

UC San Diego researchers receive CIRM grants to advance studies on Zika virus and cancer

The Independent Citizens Oversight Committee of the California Institute for Regenerative Medicine has approved a pair of $2 million awards to University of California San Diego School of Medicine researchers to advance studies of new treatments for Zika virus infections and the use of stem cell-derived natural killer (NK) cells to target ovarian cancer and other malignancies.

20 Jan 2017

New findings about key cellular protein could lead to treatments for neurodegenerative diseases

New details learned about a key cellular protein could lead to treatments for neurodegenerative diseases, such as Parkinson's, Huntington's, Alzheimer's, and amyotrophic lateral sclerosis (ALS).

27 Dec 2016

TSRI scientists reveal how vision-loss treatment may leave the eyes, kidneys vulnerable to cellular damage

A common class of drugs for vision loss may actually add to the problem in some patients, according to new research co-led by scientists at The Scripps Research Institute (TSRI).

7 Dec 2016