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Chemists develop promising molecular tool to target cell immortality's underlying gears

One of the hallmarks of cancer is cell immortality. A Northwestern University organic chemist and his team now have developed a promising molecular tool that targets and inhibits one of cell immortality's underlying gears: the enzyme telomerase.

3 Mar 2020

Observation of telomerase activity at a single-molecule level using 'optical tweezers'

Stem cells involved in replenishing human tissues and blood depend on an enzyme known as telomerase to continue working throughout our lives. When telomerase malfunctions, it can lead to both cancer and premature aging conditions.

3 Mar 2020

UAB research reveals hydrogen sulfide as new culprit for deadly tuberculosis

A new culprit -- hydrogen sulfide -- has been found for the deadly infectious disease tuberculosis. Hydrogen sulfide gas is known for its rotten egg smell, yet it has normal physiological roles in the human body to communicate among cells.

3 Mar 2020

Inhibiting specific protein could make radiation therapy for colon cancer more effective

Researchers at Washington University School of Medicine in St. Louis appear to have discovered a way to make radiation therapy for colorectal cancer more effective by inhibiting a protein found in cancer cells in the gut.

3 Mar 2020

How cannabis interacts with medications

A new practice guideline published in the journal CMAJ in February 2020 describes five types of drug interactions possible with the use of cannabis. Cannabis is a plant-derived drug containing the psychoactive ingredient delta-9-tetrahydrocannabinol (THC) and non-psychoactive cannabidiol (CBD). These cannabinoids are broken down by the liver enzymes cytochrome P450 C(YP)34A, and CYP2CC9.

2 Mar 2020

New drug could help significantly improve success rate of cancer immunotherapy

A study led by the University of Southampton, funded by Cancer Research UK, has shown a new drug - originally developed to tackle the scarring of organ tissue - could help to significantly improve the success rate of cancer immunotherapy treatment.

2 Mar 2020

ORNL story tips on antidote chasing, traffic control and automatic modeling

In the most comprehensive, structure-based approach to date, a team of scientists may have discovered a new family of antidotes for certain poisons that can mitigate their effects more efficiently compared with existing remedies.

2 Mar 2020

People with drug-induced liver damage could continue taking life-saving medications

When you ingest a drug--whether over-the-counter Tylenol or medication prescribed by a doctor--your liver is your body's first responder.

28 Feb 2020

First evidence of rare amino acid in the fruit of durian tree

Researchers at the Leibniz-Institute for Food Systems Biology at the Technical University of Munich have confirmed the presence of the rare amino acid ethionine in a plant - or more precisely, in the fruit of the durian tree.

28 Feb 2020

Study finds significant increase in skin allergy to 'bee glue'

Skin allergy to an ingredient found in many natural skin products has more than doubled since 2007, according to a study in the British Journal of Dermatology.

28 Feb 2020

Researchers show how investigational antiviral drug stops coronavirus

A team of academic and industry researchers is reporting new findings about how exactly an investigational antiviral drug stops coronaviruses.

28 Feb 2020

Gene-editing technology may lead to new model for studying Parkinson’s disease

Parkinson's disease researchers have used gene-editing tools to introduce the disorder's most common genetic mutation into marmoset monkey stem cells and to successfully tamp down cellular chemistry that often goes awry in Parkinson's patients.

27 Feb 2020

Researchers elucidate structure and function of enzyme that builds complex sugar trees

Researchers have used cryo-electron microscopy to elucidate for the first time the structure and function of a very small enzyme embedded in cell membranes.

27 Feb 2020

A retrospective review of 5,000 non-surgical rhinoplasties performed to date

As patients continue to seek non-invasive treatments across the cosmetic spectrum, "liquid rhinoplasty" is emerging as the non-surgical alternative to the traditional nose job.

27 Feb 2020

New compounds may help stop the spread of the coronavirus

Amid the global health crisis of the coronavirus (COVID-19), scientists from around the world are racing to find a treatment to stop the deadly virus. The sudden acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread across 46 countries, infecting more than 82,000 and killing more than 2,800 people.

26 Feb 2020

APEIRON Biologics launches clinical trial of respiratory drug to treat coronavirus infection

APEIRON Biologics AG, a biotechnology company with an approved product on the market as well as a broad preclinical and clinical pipeline, today announced the launch of a Pilot investigator-initiated clinical trial with APN01, a recombinant human angiotensin-converting enzyme 2, to treat patients with severe coronavirus infection in the People's Republic of China.

26 Feb 2020

Enzyme News and Research

Chemists develop promising molecular tool to target cell immortality's underlying gears

Observation of telomerase activity at a single-molecule level using 'optical tweezers'

UAB research reveals hydrogen sulfide as new culprit for deadly tuberculosis

Inhibiting specific protein could make radiation therapy for colon cancer more effective

How cannabis interacts with medications

New drug could help significantly improve success rate of cancer immunotherapy

ORNL story tips on antidote chasing, traffic control and automatic modeling

People with drug-induced liver damage could continue taking life-saving medications

First evidence of rare amino acid in the fruit of durian tree

Study finds significant increase in skin allergy to 'bee glue'

Researchers show how investigational antiviral drug stops coronavirus

Gene-editing technology may lead to new model for studying Parkinson’s disease

Researchers elucidate structure and function of enzyme that builds complex sugar trees

A retrospective review of 5,000 non-surgical rhinoplasties performed to date

New compounds may help stop the spread of the coronavirus

APEIRON Biologics launches clinical trial of respiratory drug to treat coronavirus infection

Gene-editing is more error-prone than thought, new findings suggest

Aggressive cancers set up a structural framework to keep the immune system at bay

Researchers uncover how cancer cells override environmental cues to consume energy

Researchers explore whether plaque identifying toothpaste could prevent heart attack, stroke

Biochemical Assays for Efficient Hit Prioritization After Screening eBook

Latest eBooks

Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

Industry Focus eBook - Cell biology (5th edition)

Advancing degrader and proximity-based drug development

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo