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FIND explores new diagnostic assays for confirmatory HCV diagnosis in community settings

The Foundation for Innovative New Diagnostics today announced awards to support the development, manufacture and feasibility testing of two prototype hepatitis C virus core antigen immunoassays for confirmatory HCV diagnosis at the point of care.

16 Nov 2018

Researchers find metabolite shuttle between cells in the liver that may combat tissue fibrosis

University of Minnesota Medical School researchers have made a discovery which could lead to a new way of thinking about how disease pathogenesis in the liver is regulated, which is important for understanding the condition nonalcoholic fatty liver disease, which is incredibly common and growing.

16 Nov 2018

Benefit-harm balance of hepatitis B and C screening is unclear due to lack of informative evidence

Hepatitis B and hepatitis C are viral infections, which are mostly transmitted by blood. Often unnoticed, they can become chronic, causing irreversible damage to the liver.

15 Nov 2018

NIH researchers shed light on causes of HBV-associated acute liver failure

National Institutes of Health scientists and their collaborators found that hepatitis B virus-associated acute liver failure--a rare condition that can turn fatal within days without liver transplantation--results from an uncommon encounter between a highly mutated HBV variant and an unusual immune response in the patient's liver that is mainly sustained by antibody-producing B cells.

14 Nov 2018

Study shows new emerging role of osteopontin in HCV-related hepatocellular carcinoma

Hepatitis C virus (HCV) infection is the major cause of hepatocellular carcinoma (HCC) and was estimated to be responsible for 745,000 deaths in 2012.

13 Nov 2018

Cancer stem cells depend on amino acid metabolism, and it's proving to be their Achilles' heel

Think of energy metabolism like a party popper: Ripping something apart releases a bang. Most of your cells rip apart sugar to release the "bang" of energy. Sometimes they rip apart fats, and in a pinch, cells can even metabolize protein.

13 Nov 2018

Study identifies factors tied to greater risk of advanced liver disease in cystic fibrosis patients

Children's Hospital Colorado pediatric gastroenterologist, Michael Narkewicz, MD, recently shared results of the Prospective Study of Ultrasound to Predict Hepatic Cirrhosis in Cystic Fibrosis, which sought to determine if liver ultrasounds could identify children and adolescents with cystic fibrosis who are at greater risk of developing advanced liver disease.

13 Nov 2018

Study finds lack of safety data for using flowers in cooking

A study of 23 flowers used in cooking shows a lack of chemical and toxicological data, which makes it impossible to set a limit for safe consumption, according to the National Food Institute, Technical University of Denmark.

12 Nov 2018

Inexpensive and effective drug does not reduce major adverse cardiovascular event rates

When it comes to reducing inflammation to decrease the risk of heart disease and stroke, results from the much-anticipated Cardiovascular Inflammation Reduction Trial indicate that targeting the right inflammatory pathways in at-risk patients is crucial.

12 Nov 2018

The Human Mini Heart-in-a-Jar That Could One Day Replace Animal Testing

An interview with Dr. Kevin Costa, discussing the miniaturized heart-in-a-jar model developed by Novoheart, and its applications in personalized medicine.

12 Nov 2018

New thrombolytic based on magnetite nanoparticles successfully tested on animals

New anti-thrombosis drug based on magnetite nanoparticles developed at ITMO University was successfully tested on animals. Preclinical studies conducted in terms of the project "PHARMA 2020" showed drug's high efficacy and no side effects.

9 Nov 2018

Salk researchers solve genetic 'whodunnit' for cancer gene

Long thought to suppress cancer by slowing cellular metabolism, the protein complex AMPK also seemed to help some tumors grow, confounding researchers. Now, Salk Institute researchers have solved the long-standing mystery around why AMPK can both hinder and help cancer.

8 Nov 2018

Researchers identify epigenetic changes that increase risk of type 2 diabetes

Small chemical changes in the DNA building blocks, which may be influenceable by lifestyle factors, can reduce the amount of IGFBP2. A DIfE / DZD research team has now reported in the journal Diabetes that these epigenetic changes increase the risk of type 2 diabetes.

8 Nov 2018

GW study examines impact of nervous system on non-alcoholic fatty liver disease

Non-alcoholic fatty liver disease, the accumulation of fat in the liver of people who drink little or no alcohol, affects 1 in 3 Americans. NAFLD is a significant risk factor for Type 2 diabetes, insulin resistance, and hepatic carcinoma, and incidence of the disease is increasing with the growing obesity epidemic in the United States.

8 Nov 2018

Targeted radiation provides treatment option for children with hard-to-treat liver cancer

Targeted tumor radiation provides a feasible treatment option for children with difficult-to-treat liver cancer, according to a new study published today in the journal Pediatric Blood and Cancer.

8 Nov 2018

Circadian clock could play key role in the fight against liver cancer

The body's internal clock could play a critical role in the fight against certain types of liver cancer, according to a preclinical study by scientists from The University of Texas Health Science Center at Houston (UTHealth). The results were published recently in the journal Nature Communications.

8 Nov 2018

Study could provide novel treatment strategy for potentially blinding problem

An enzyme known to help our liver get rid of ammonia also appears to be good at protecting our retina, scientists report.

8 Nov 2018

Cholesterol-lowering drug reduces chance of having second heart problems or stroke

In a clinical trial involving 18,924 patients from 57 countries who had suffered a recent heart attack or threatened heart attack, researchers at the University of Colorado Anschutz Medical Campus and fellow scientists around the world have found that the cholesterol-lowering drug alirocumab reduced the chance of having additional heart problems or stroke.

8 Nov 2018

New open source decision support tool could help clinicians chose chemotherapy drugs

The selection of a first-line chemotherapy drug to treat many types of cancer is often a clear-cut decision governed by standard-of-care protocols, but what drug should be used next if the first one fails?

8 Nov 2018

Regenerative medicine scientist receives $1.3 million to study stem cell therapy for liver failure

Currently, the only therapy for metabolic liver disease is an organ transplant. Tracy Grikscheit, MD, an attending physician and regenerative medicine scientist at Children's Hospital Los Angeles, hopes to change that reality.

7 Nov 2018

Liver News and Research

FIND explores new diagnostic assays for confirmatory HCV diagnosis in community settings

Researchers find metabolite shuttle between cells in the liver that may combat tissue fibrosis

Benefit-harm balance of hepatitis B and C screening is unclear due to lack of informative evidence

NIH researchers shed light on causes of HBV-associated acute liver failure

Study shows new emerging role of osteopontin in HCV-related hepatocellular carcinoma

Cancer stem cells depend on amino acid metabolism, and it's proving to be their Achilles' heel

Study identifies factors tied to greater risk of advanced liver disease in cystic fibrosis patients

Study finds lack of safety data for using flowers in cooking

Inexpensive and effective drug does not reduce major adverse cardiovascular event rates

The Human Mini Heart-in-a-Jar That Could One Day Replace Animal Testing

New thrombolytic based on magnetite nanoparticles successfully tested on animals

Salk researchers solve genetic 'whodunnit' for cancer gene

Researchers identify epigenetic changes that increase risk of type 2 diabetes

GW study examines impact of nervous system on non-alcoholic fatty liver disease

Targeted radiation provides treatment option for children with hard-to-treat liver cancer

Circadian clock could play key role in the fight against liver cancer

Study could provide novel treatment strategy for potentially blinding problem

Cholesterol-lowering drug reduces chance of having second heart problems or stroke

New open source decision support tool could help clinicians chose chemotherapy drugs

Regenerative medicine scientist receives $1.3 million to study stem cell therapy for liver failure

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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