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Janssen Biotech, Molecular Partners collaborate to develop DARPins for immunological diseases

Molecular Partners AG today announced that it has entered into a strategic research collaboration and option agreement with Janssen Biotech, Inc. to research, discover and develop DARPin products for the treatment of immunological diseases.

8 Dec 2011

Ampio awarded composition of matter patent for Ampion in Europe

Ampio Pharmaceuticals, Inc., a company that discovers and develops new uses for previously approved drugs and new molecular entities, today announced receipt of notification of the granting of a European patent with broad claims directed to compositions containing DA-DKP, a cyclic dipeptide diketopiperazine which is the active ingredient of Ampion™.

7 Dec 2011

Scientists help uncover evolutionary history of TAS2R38 bitter taste receptor gene

Long the bane of picky eaters everywhere, broccoli's taste is not just a matter of having a cultured palate; some people can easily taste a bitter compound in the vegetable that others have difficulty detecting. Now a team of Penn researchers has helped uncover the evolutionary history of one of the genes responsible for this trait.

7 Dec 2011

INT-777 shows promise against metabolic syndrome

Heart disease is a major cause of death in industrialised countries, and is strongly associated with obesity and diabetes. Many scientists believe that what links these conditions is a chronic, low-grade inflammation.

7 Dec 2011

Study reveals mechanism of action of laquinimod in patients with RRMS

Laquinimod is an orally available synthetic compound that has been successfully evaluated in phase II/III clinical studies for the treatment of relapsing-remitting multiple sclerosis (RRMS).

6 Dec 2011

Bold move by Astra Zeneca to share 22 early stage potential drugs with MRC

Drug maker AstraZeneca will be sharing 22 of its early-stage research compounds with the Medical Research Council as part of a make over of life sciences research. This would speed up patients’ access to breakthrough drugs and arrest the decline of research and development in the UK.

6 Dec 2011

Dye derived from Canary Island lichens may help treat Alzheimer's disease

A red dye derived from lichens that has been used for centuries to color fabrics and food appears to reduce the abundance of small toxic protein aggregates in Alzheimer's disease. The dye, a compound called orcein, and a related substance, called O4, bind preferentially to small amyloid aggregates that are considered to be toxic and cause neuronal dysfunction and memory impairment in Alzheimer's disease.

3 Dec 2011

Pfizer acquires Excaliard

Pfizer Inc. announced today that it has completed its acquisition of Excaliard Pharmaceuticals, Inc., a privately owned biopharmaceutical company focused on developing novel drugs for the treatment of skin fibrosis, more commonly referred to as skin scarring.

3 Dec 2011

White tea, witch hazel and rose have potential health and beauty properties

Age-old remedies could hold the key to treating a wide range of serious medical problems, as well as keeping skin firmer and less wrinkled, according to scientists from London's Kingston University.

2 Dec 2011

New method reveals complete set of aberrant signaling pathways that give rise to cancers

One major obstacle in the fight against cancer is that anticancer drugs often affect normal cells in addition to tumor cells, resulting in significant side effects. Yet research into development of less harmful treatments geared toward the targeting of specific cancer-causing mechanisms is hampered by lack of knowledge of the molecular pathways that drive cancers in individual patients.

2 Dec 2011

Global external defibrillators market to grow at 6% CAGR to exceed $2.2 billion by 2017

Global Information, Inc. (GII) presents "External Defibrillators - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017" by GlobalData.

2 Dec 2011

Adding a dip can induce bitter sensitive children to eat more vegetables

There's an existential crisis that often happens at dinner tables across the country: why won't kids eat their vegetables? Research has found that one reason could be a sensitivity to bitterness, fairly common among children - about 70 percent have it.

2 Dec 2011

Scripps scientist receives NIH grant for HIV/AIDS research

A scientist at The Scripps Research Institute has been awarded $3.4 million from the National Institutes of Health to study the mode of action and the therapeutic potential of a new compound that blocks a step of HIV replication not targeted by current therapies.

1 Dec 2011

Scientists create genetically-altered neurons that light up as they fire

In a scientific first that potentially could shed new light on how signals travel in the brain, how learning alters neural pathways, and might lead to speedier drug development, scientists at Harvard have created genetically-altered neurons that light up as they fire.

30 Nov 2011

FDA assigns priority-review designation for ELIQUIS NDA for stroke prevention in atrial fibrillation

Bristol-Myers Squibb Company and Pfizer Inc. today announced that the U.S. Food and Drug Administration (FDA) has accepted for review a New Drug Application (NDA) for ELIQUIS® (apixaban), an investigational compound for the prevention of stroke and systemic embolism in patients with atrial fibrillation.

29 Nov 2011

New technique to accomplish 'accelerated serendipity' using robotics

Scientists can now take that "a-ha" moment to go with a method Princeton University researchers developed - and successfully tested - to speed up the chances of an unexpected yet groundbreaking chemical discovery.

29 Nov 2011

Scientists use genetic methods to successfully repair cleft lips in mice embryos

Scientists at Weill Cornell Medical College used genetic methods to successfully repair cleft lips in mice embryos specially engineered for the study of cleft lip and cleft palate. The research breakthrough may show the way to prevent or treat the conditions in humans.

29 Nov 2011

New compound circumvents drug-efflux pumps associated with Gram-positive bacteria

It's no wonder that medicine's effort to combat bacterial infections is often described as an arms race. When new drugs are developed to combat infections, the bacterial target invariably comes up with a deterrent.

29 Nov 2011

Exelixis and NCI's CTEP enter CRADA to further evaluate cabozantinib

Exelixis, Inc. today announced that it has entered into a Cooperative Research and Development Agreement (CRADA) with the National Cancer Institute's Cancer Therapy Evaluation Program (CTEP) for further evaluation of cabozantinib, Exelixis' lead compound, in a variety of solid tumors.

28 Nov 2011

Novel proteomics based method detects inhibition of intracellular deubiquitylating enzymes

Researchers at the University of Oxford and Progenra, Inc. are pleased to announce the publication of a research article entitled "Activity-Based Chemical Proteomics Accelerates Inhibitor Development for Deubiquitylating Enzymes" that details a novel proteomics based method to detect inhibition of intracellular deubiquitylating enzymes (DUBs).

28 Nov 2011

Compound News and Research

Janssen Biotech, Molecular Partners collaborate to develop DARPins for immunological diseases

Ampio awarded composition of matter patent for Ampion in Europe

Scientists help uncover evolutionary history of TAS2R38 bitter taste receptor gene

INT-777 shows promise against metabolic syndrome

Study reveals mechanism of action of laquinimod in patients with RRMS

Bold move by Astra Zeneca to share 22 early stage potential drugs with MRC

Dye derived from Canary Island lichens may help treat Alzheimer's disease

Pfizer acquires Excaliard

White tea, witch hazel and rose have potential health and beauty properties

New method reveals complete set of aberrant signaling pathways that give rise to cancers

Global external defibrillators market to grow at 6% CAGR to exceed $2.2 billion by 2017

Adding a dip can induce bitter sensitive children to eat more vegetables

Scripps scientist receives NIH grant for HIV/AIDS research

Scientists create genetically-altered neurons that light up as they fire

FDA assigns priority-review designation for ELIQUIS NDA for stroke prevention in atrial fibrillation

New technique to accomplish 'accelerated serendipity' using robotics

Scientists use genetic methods to successfully repair cleft lips in mice embryos

New compound circumvents drug-efflux pumps associated with Gram-positive bacteria

Exelixis and NCI's CTEP enter CRADA to further evaluate cabozantinib

Novel proteomics based method detects inhibition of intracellular deubiquitylating enzymes

Advancing therapeutic biopolymer development eBook

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

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