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Regulating neuronal lipid metabolism helps axon regeneration after injury, study finds

Typical examples include paralysis due to a spinal cord injury and visual field atrophy or even complete blindness due to optic nerve atrophy in glaucoma patients.

30 Jan 2020

Research reveals key molecular target for colorectal cancer therapy

Serine racemase is a multifunctional enzyme that carries out several different reactions in human cells, including the conversion of L-serine into pyruvate.

29 Jan 2020

UB team receives $2 million NIH grant for enzyme research

In the human body, proteins called enzymes help speed up chemical reactions that are vital for life.

29 Jan 2020

Bandages sense infections, change color, treat infection

In what reads like science fiction, a new study published in the journal ACS Central Science reports the development of bandages that detect the presence of bacteria in wounds and change color, depending on whether they are drug-sensitive or drug-resistant. This is an important step in helping patients recover better.

29 Jan 2020

Avacta demonstrates initial proof-of-concept for TMAC drug conjugates in pre-clinical study

Avacta Group plc, the developer of Affimer biotherapeutics and reagents, is pleased to announce that it has demonstrated initial proof-of-concept for its proprietary new class of drug conjugate, TMAC, in a pre-clinical animal model of cancer.

From Avacta Life Sciences Ltd. 28 Jan 2020

Researchers discover how CDK8 oncogene gets activated in healthy humans

Most cancers are caused by a large variety of factors that vary from one person to another. To unravel this complexity, genes that contribute to the development of a respective cancer must be identified. Such genes are called oncogenes. A good example of an oncogene is CDK8: Cyclin-dependent kinase 8.

28 Jan 2020

Low-protein diet throughout pregnancy and lactation may increase risk of liver damage

A study in rats examines a pathway through which protein deficiency during pregnancy leads to fat accumulation in the liver and increased risk of liver damage.

28 Jan 2020

Study suggests prenatal origin for ‘young’ Parkinson’s disease

A new study published in the journal Nature Medicine on January 2020 suggests that Parkinson’s disease developing before the age of 50 years could be due to an abnormality in certain brain cells that remains dormant until the age of onset of the disease. It also indicates the potential usefulness of a specific drug to prevent this by correcting the brain cell disorder.

27 Jan 2020

Parkinson's disease may affect brain cells before birth

People who develop Parkinson's disease before age 50 may have been born with disordered brain cells that went undetected for decades, according to new Cedars-Sinai research. The research points to a drug that potentially might help correct these disease processes.

27 Jan 2020

Weak evidence found on added benefit of asfotase alfa treatment for infants with hypophosphatasia

Hypophosphatasia (HPP) is a rare congenital metabolic disorder. The frequency of severe courses of disease is estimated at 1:100 000: A deficiency of the enzyme phosphatase results in insufficient mineralization of the bones and thus in severe skeletal malformations.

27 Jan 2020

T. gondii parasite employs a sophisticated manipulation to suppress host's immune response

Toxoplasma gondii is best known as the parasite that may lurk in a cat's litter box. Nearly a third of the world's population is believed to live with a chronic Toxoplasma infection.

24 Jan 2020

Stanford scientists complete first global census of cell surface proteins

Stanford scientists have completed the first global census of diverse proteins sprouting tree-like from the outer membrane of a cell. These cell surface proteins govern how cells interact with one another and how they assemble into tissues and organs such as hearts and brains.

24 Jan 2020

Arginine depletion could form the basis for potential rheumatoid arthritis therapies

A group from the MedUni Vienna has identified a role for the endogenous amino acid arginine in the growth of osteoclasts in rheumatoid arthritis.

23 Jan 2020

Study finds stress does whiten hair

In most cases, hair starts to gray in the thirties, and becomes pronounced in the fifties, at which time the head is typically crowned with a thatch of white, gray and perhaps some hair of the original color. A new study published January 2020 in the journal Nature, shows that this process is speeded up significantly by acute stress persisting over a period, or by severe trauma.

22 Jan 2020

Aging of urine fertilizer prevents transfer of antibiotic resistance

The use of human urine as fertilizer is an important step towards sustainable agriculture because the starting reagent is free, plentiful and useless in most other contexts. It has been used as such for centuries, but with the current focus on environmental sustainability, the possibility of creating a nutrient cycle is under scrutiny. In other words, sourcing fertilizer from urine can be a green way to supply plants with the nutrients they need.

22 Jan 2020

Researchers identify potential way to halt age-related macular degeneration

Researchers have successfully treated age-related macular degeneration in mice after finding an unexpected link between the two main forms of the blinding eye disease, the leading cause of vision loss in people 60 and older.

22 Jan 2020

Study sheds light on mechanisms that underlie a rare genetic condition

A team of researchers at CHU Sainte-Justine and Université de Montréal has shed light on the mechanisms that underlie a rare genetic condition by creating the first cellular model of the disease.

22 Jan 2020

Scientists develop capsule shell composition for enzyme needed to treat phenylketonuria

IKBFU scientists developed the composition of the capsule shell for the enzyme needed in the treatment of a hereditary disease called "phenylketonuria".

21 Jan 2020

Depression treatment must also restore integrity of the blood-brain barrier

To better treat people with depression, not only must we treat the neurons affected by the disease, but we must also restore the integrity of the barrier that regulates exchanges between blood circulation and the brain.

21 Jan 2020

New analysis method shows how the brain regulates its signals using glutamate

Researchers at Chalmers University of Technology and Gothenburg University in Sweden have achieved something long thought almost impossible - counting the molecules of the neurotransmitter glutamate released when a signal is transferred between two brain cells. With a new analysis method, they showed that the brain regulates its signals using glutamate in more ways than previously realised.

21 Jan 2020