Inflammation News and Research

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Public-private collaboration receives grant for research on microbiota-boosted cancer therapy

Health~Holland has awarded close to € 800,000 to a public-private partnership between UMC Utrecht, Artizan Biosciences, Inc. (USA) and MicroViable Therapeutics (Spain) to unravel how the intestinal microbiota can be exploited to boost cancer immunotherapy and limit therapy side-effects.

21 Sep 2022

Genome-based microbiome signature associated with the severity and prognosis of COVID-19 in hospitalized patients

Researchers evaluated the association between guild-level microbiome signature and the severity and prognosis of SARS-CoV-2 infections by a genome-level metagenomic analysis.

21 Sep 2022

Common genetic variants of APOE associated with COVID mortality

It may be the most baffling quirk of COVID: What manifests as minor, flu-like symptoms in some individuals spirals into severe disease, disability, and even death in others.

21 Sep 2022

Prophylactic administration of SARS-CoV-2 specific immunoglobulin Y generated in chicken eggs displays protective effects in infected mice

A new study characterized and tested the antibody activity of SARS-CoV-2-specific immunoglobulin Y (IgY) derived from the eggs laid by chickens immunized with recombinant SARS-CoV-2 receptor binding domain (RBD) protein.

21 Sep 2022

Why fatigue from long COVID goes beyond simply feeling tired

In a recent study posted to the medRxiv* preprint server, researchers in the Netherlands examined the role of inflammatory genes, cytotoxic T-lymphocytes (CD8+ T cells), and pro-inflammatory cytokines in long-lasting severe fatigue experienced by a large number of coronavirus disease 2019 (COVID-19) patients.

21 Sep 2022

Researchers successfully deliver a common blood pressure drug directly to cells’ ‘power plants’

In a study using lab-grown cells, Johns Hopkins Medicine researchers specializing in aging report they have successfully delivered a common blood pressure drug directly to the inner membrane of mitochondria, the "power plants" in the cells of humans, animals, plants and most other organisms.

20 Sep 2022

Tumors generate unique, temporary cell-in-cell structures to evade immunotherapy

Scientists have shown how tumour cells evade immunotherapy by generating unique, temporary cell-in-cell structures, where the inner cells remain in tact and can return to single tumour cells.

20 Sep 2022

UTHSC-led researchers receive $5.2 million to study obesity-mediated cancer risk

The National Cancer Institute has awarded more than $5.2 million to a team lead by researchers from the University of Tennessee Health Science Center for a study that will fill critical gaps in knowledge around obesity-mediated cancer risk.

20 Sep 2022

Healthy people with high cholesterol don't stand to benefit from statins, research says

About 40 million adults in the United States regularly take statins to lower their cholesterol levels and reduce their risk of heart disease and stroke, according to American Heart Association data from 2020.

20 Sep 2022

High-fat diets drive the production of inflammatory immune cells in the bone marrow of mice

Scientists have shown that high-fat diets can cause rapid changes in the bone marrow of mice, driving the production of inflammatory immune cells, according to findings published today in eLife.

20 Sep 2022

Overload of stress granules enables the growth of obesity-related pancreatic cancer

Obesity is a known risk factor for at least 13 types of cancer, in part because it creates ever-present inflammatory state. For years, one researcher has wondered if there's more to the story than inflammation.

20 Sep 2022

Researchers provide critical insights into the molecular mechanisms underlying lysophagy

Autophagy is a self-degradation process that cells use to remove unneeded or damaged components. There are several forms of autophagy, including macroautophagy, which is a bulk degradation system used to target materials in the cell's cytosol to organelles called lysosomes for enzymatic breakdown.

20 Sep 2022

Molecular engineered low-cost highly effective RBD-based COVID vaccine

In a recent study posted to the bioRxiv* preprint server, an international team of researchers developed a second-generation severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor binding domain (RBD) antigen (RBD-J6) by molecular engineering with two additional amino acid (aa) substitutions (S383D and L518D mutations) in a hydrophobic cryptic RBD core epitope to enhance stability and expression against SARS-CoV-2 variants of concern (VOCs).

19 Sep 2022

Intact autophagic vacuoles found to be indispensable in mediating competitive elimination of cancer cells

Elimination of transformed cells that can initiate cancer is necessary to maintain tissue integrity. In a new study, scientists from Tokyo University of Science show how this mechanism is regulated by the cellular process "autophagy."

19 Sep 2022

First multi-center, large-scale registry of severe asthma patients launched in Singapore

A research network formed by Nanyang Technological University, Singapore's (NTU Singapore) Lee Kong Chian School of Medicine (LKCMedicine), Changi General Hospital (CGH), Singapore General Hospital (SGH), and Tan Tock Seng Hospital (TTSH) has set up the Singapore Severe Asthma Registry (SSAR), the first of its kind in the country.

19 Sep 2022

Monkeypox virus infection in an immunocompromised patient

Researchers assessed the manifestations of the monkeypox infection in an immunocompromised patient.

19 Sep 2022

Soy protein diet increases susceptibility to Clostridioides difficile infection

According to a recent study published in the journal Cell Reports, a diet rich in soy protein increases human Clostridioides difficile susceptibility by increasing the gut amino acids (AAs) levels and promoting the growth of Lactobacillus.

18 Sep 2022

Research examines the roles of cytokines during SARS-CoV-2 infection in rhesus macaques

In a recent study posted to the bioRxiv* preprint server, researchers in the United States assessed the role of two cytokines, interferon-gamma (IFN-γ) and interleukin-10 (IL-10), in regulating immune cell responses and inflammation early during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in rhesus macaques.

18 Sep 2022

COVID-19 increases risk of developing Alzheimer's by 50-80% in older adults

In a recent study published in the Journal of Alzheimer’s Disease, researchers investigated whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections could trigger the development of new-onset Alzheimer’s disease (AD)

18 Sep 2022

UCLA announces participation in a phase 3 trial evaluating tecovirimat for the treatment of monkeypox

The UCLA Clinical AIDS Research and Education (CARE) Center today announced its participation in STOMP (Study of Tecovirimat for Human Monkeypox Virus), or A5418, a phase 3, randomized, placebo-controlled, double-blind trial evaluating the safety and efficacy of tecovirimat for the treatment of human monkeypox.

16 Sep 2022

Inflammation News and Research

Public-private collaboration receives grant for research on microbiota-boosted cancer therapy

Genome-based microbiome signature associated with the severity and prognosis of COVID-19 in hospitalized patients

Common genetic variants of APOE associated with COVID mortality

Prophylactic administration of SARS-CoV-2 specific immunoglobulin Y generated in chicken eggs displays protective effects in infected mice

Why fatigue from long COVID goes beyond simply feeling tired

Researchers successfully deliver a common blood pressure drug directly to cells’ ‘power plants’

Tumors generate unique, temporary cell-in-cell structures to evade immunotherapy

UTHSC-led researchers receive $5.2 million to study obesity-mediated cancer risk

Healthy people with high cholesterol don't stand to benefit from statins, research says

High-fat diets drive the production of inflammatory immune cells in the bone marrow of mice

Overload of stress granules enables the growth of obesity-related pancreatic cancer

Researchers provide critical insights into the molecular mechanisms underlying lysophagy

Molecular engineered low-cost highly effective RBD-based COVID vaccine

Intact autophagic vacuoles found to be indispensable in mediating competitive elimination of cancer cells

First multi-center, large-scale registry of severe asthma patients launched in Singapore

Monkeypox virus infection in an immunocompromised patient

Soy protein diet increases susceptibility to Clostridioides difficile infection

Research examines the roles of cytokines during SARS-CoV-2 infection in rhesus macaques

COVID-19 increases risk of developing Alzheimer's by 50-80% in older adults

UCLA announces participation in a phase 3 trial evaluating tecovirimat for the treatment of monkeypox

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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