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New test could help medics to quickly diagnose urinary tract infections

Biological Engineers at the University of Bath have developed a test that could help medics quickly diagnose urinary tract infections, using a normal smartphone camera.

8 Jan 2020

Persistent TB infection of macrophages puts the brakes on immune engines, study shows

Scientists from Trinity College Dublin have discovered both how TB puts the brakes on our immune engines and how we can kick-start those engines back into gear - providing hope that improved treatment options could soon be on the horizon.

8 Jan 2020

Extremely low concentrations of acetic acid could alter cellular processes in rice blast fungus

All living organisms respond and adapt to changes in their environment. These responses are sometimes so significant that they cause alterations in the internal metabolic cycles of the organism--a process called "metabolic switching." For example, rice blast fungus--a pathogenic fungal species that causes the "rice blast" infection in rice crops--switches to the "glyoxylate cycle" when the nutrient source starts to deplete.

8 Jan 2020

Biodegradable nanoparticle can deliver 'suicide gene' to pediatric brain tumor cells in mice

Johns Hopkins researchers report that a type of biodegradable, lab-engineered nanoparticle they fashioned can successfully deliver a "suicide gene" to pediatric brain tumor cells implanted in the brains of mice.

8 Jan 2020

Mayo Clinic researchers seek radical new approach to treat cocaine addition

In a radical new approach to treat cocaine addition, researchers at the Mayo Clinic are seeking approval for first-in-human studies of a single-dose gene therapy.

7 Jan 2020

Study hints a link between disruptions to progesterone signaling and recurrent miscarriage

About twenty percent of confirmed pregnancies end in miscarriage, most often in the first trimester, for reasons ranging from infection to chromosomal abnormality.

6 Jan 2020

Discovery of cellular 'hands' could have implications in the fields of cell, developmental biology

The protein, called syndecan-4, combines with fellow cell membrane proteins, called integrins, to form protruding 'hands' that sense the environment outside the cell.

6 Jan 2020

Ancestral-sequence reconstruction of FMO genes unveils structure of important enzyme

To disarm toxic substances, many organisms - including humans - possess enzymes called flavin-containing monooxygenases. Despite their importance, the structure of the enzymes has not been resolved, as the protein is too unstable to study in detail.

23 Dec 2019

New 'fishing' technique to detect thousands of proteins

A new study published today in the journal Nature Cell Biology reports the use of a novel fishing method, under microscopy, to pick up thousands of proteins that are involved in supervising how the cell skeleton is assembled.

23 Dec 2019

Research findings may one day help keep ALS at bay

A new study published in the journal Nature Medicine on December 23, 2019, shows how to silence a defective gene responsible for the degeneration of the motor neurons in Lou Gehrig’s disease, or amyotrophic lateral sclerosis (ALS), in adult mice. This could help prevent disease progression if the condition is already symptomatic, and even suppress the illness if it has not yet started.

23 Dec 2019

Immunosupressant combination therapy for glioblastoma shows promise

Researchers from the University of Texas have found an immunosuppressing target for the treatment of glioblastoma. In mice studies the team has identified CD73 macrophages which could be used to treat the cancers. The team also performed studies on human tumours to arrive at their conclusions. The study was published in the latest issue of the journal Nature Medicine this week.

23 Dec 2019

Research shows how the hepatitis D virus copies itself

A team of researchers has discovered how one crucial step occurs in the lifecycle of the hepatitis D virus (HDV), which causes the widespread and hard to treat liver inflammation called hepatitis D. The study, which was published recently in the Journal of Virology, could help develop antiviral therapy to control this disease.

22 Dec 2019

Inhibition of a single enzyme may reduce heparin-induced thrombocytopenia

Heparin is widely used as an anticoagulant, but evokes in some patients a potentially life-threatening condition called HIT. Clinical scientists at Ludwig-Maximilians-Universitaet in Munich have now shown that inhibition of a single enzyme may markedly reduce this risk.

21 Dec 2019

Kobe scientists develop mathematical model to predict cancer drug side effects

A research team at Kobe University Hospital have further illuminated the likelihood of cancer drug side effects that can occur due to genetic mutations in the drug-metabolizing enzyme.

20 Dec 2019

Caffeine may offset some negative health effects of obesogenic diet

A new study in rats suggests that caffeine may offset some of the negative effects of an obesogenic diet by reducing the storage of lipids in fat cells and limiting weight gain and the production of triglycerides.

19 Dec 2019

Researchers reveal the mystery in replication cycle of hepatitis D virus

A team led by Professor Patrick Labonté at the Institut National de la Recherche Scientifique in Montreal, Canada has identified the role of a key process in the replication cycle of the hepatitis D virus, an infection that is still very difficult to cure and affects 15 to 20 million people worldwide.

19 Dec 2019

Severe skin and mucous membrane lesions may occur in children with bacterial pneumonia

Painful inflammatory lesions of the skin and mucous membranes may occur in children who develop bacterial pneumonia.

19 Dec 2019

Artificial sweetener derivatives show improved activity against tumor-associated enzymes

Saccharin received a bad rap after studies in the 1970s linked consumption of large amounts of the artificial sweetener to bladder cancer in laboratory rats. Later, research revealed that these findings were not relevant to people.

18 Dec 2019

New paper-based test for early Lyme diagnosis

A new paper in the journal ACS Nano reports the development of an incredibly cheap and highly sensitive test to diagnose Lyme disease in its earliest stages, when it can be most easily, effectively and inexpensively treated.

18 Dec 2019

Scientists use supercomputers to shed light on skin cancer formation mechanism

Skin cancer, particularly melanoma, which is the deadliest and most serious type of human skin cancer, begins as a small lesion or blemish. Usually, these blemishes start off as harmless accumulation of melanocytes, which give the skin its color. As the disease progresses, it can spread throughout the body.

18 Dec 2019

Enzyme News and Research

New test could help medics to quickly diagnose urinary tract infections

Persistent TB infection of macrophages puts the brakes on immune engines, study shows

Extremely low concentrations of acetic acid could alter cellular processes in rice blast fungus

Biodegradable nanoparticle can deliver 'suicide gene' to pediatric brain tumor cells in mice

Mayo Clinic researchers seek radical new approach to treat cocaine addition

Study hints a link between disruptions to progesterone signaling and recurrent miscarriage

Discovery of cellular 'hands' could have implications in the fields of cell, developmental biology

Ancestral-sequence reconstruction of FMO genes unveils structure of important enzyme

New 'fishing' technique to detect thousands of proteins

Research findings may one day help keep ALS at bay

Immunosupressant combination therapy for glioblastoma shows promise

Research shows how the hepatitis D virus copies itself

Inhibition of a single enzyme may reduce heparin-induced thrombocytopenia

Kobe scientists develop mathematical model to predict cancer drug side effects

Caffeine may offset some negative health effects of obesogenic diet

Researchers reveal the mystery in replication cycle of hepatitis D virus

Severe skin and mucous membrane lesions may occur in children with bacterial pneumonia

Artificial sweetener derivatives show improved activity against tumor-associated enzymes

New paper-based test for early Lyme diagnosis

Scientists use supercomputers to shed light on skin cancer formation mechanism

Biochemical Assays for Efficient Hit Prioritization After Screening eBook

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Industry Focus eBook - Analytical Chemistry (3rd edition)

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