Fatigue News and Research

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FDA denies accelerated approval of Genentech's trastuzumab-DM1 (T-DM1) BLA for metastatic breast cancer

In its review of the BLA, the FDA stated the T-DM1 trials did not meet the standard for accelerated approval because all available treatment choices approved for metastatic breast cancer, regardless of HER2 status, had not been exhausted in the study population.

27 Aug 2010

New vibration technology to reduce stubborn stomach fat

For millions of dieters it seems impossible to lose belly fat no matter however carefully they watch what they eat or how many sit-ups they do. Some people give up and blame it on genetics, metabolism or body type and simply accept it as a fact of life. For whatever the reason, many Americans discover that stubborn fat around the stomach and love handles will not melt away despite their best efforts. Now a fitness research company says there is an effective way to win the battle of the bulge without special diets, drinks or difficult exercises.

27 Aug 2010

Treating metastatic melanoma tumors with specific genetic signature shows promising results

Use of an experimental targeted drug to treat metastatic melanoma tumors with a specific genetic signature was successful in more than 80 percent of patients in a phase 1 clinical trial.

26 Aug 2010

PLX4032 therapy results in tumor shrinkage in metastatic melanoma patients

A multicenter study has concluded that treatment with a new targeted therapy called PLX4032 (also called RG7204) resulted in significant tumor shrinkage in 80 percent of patients with advanced melanoma.

26 Aug 2010

Gatherer Partnership to advance patient rehabilitation, conditioning techniques

New company to create objective analysis and measurement physiotherapy products to improve support for critical decisions relating to patient assessment, condition and the need for surgical intervention.

24 Aug 2010

Epilepsy Therapy Project, EF announce recipients of New Therapy Grants Program

The Epilepsy Therapy Project (ETP) and the Epilepsy Foundation (EF) today announced the latest grant recipients of its New Therapy Grants Program, a unique joint venture of the non-profit epilepsy organizations, to advance promising epilepsy research in clinical development. The grant awards, totaling approximately $200,000 in funding, will support an experimental gene therapy that directly targets epileptogenic brain tissue, as well as an electrode system that has the potential to improve the efficacy of surgical therapies for certain epilepsy syndromes.

24 Aug 2010

Researchers find gene sequences of MLV in chronic fatigue syndrome patients' blood samples

Researchers have found murine leukemia viruses (MLV) related gene sequences in blood samples collected from patients diagnosed with chronic fatigue syndrome (CFS) and some healthy blood donors, according to a study published online today by the scientific journal Proceedings of the National Academy of Sciences (PNAS).

24 Aug 2010

NCF announces formal disease model for Chronic Fatigue Syndrome

The National CFIDS Foundation Inc., of Needham Mass, has announced its formal disease model for Chronic Fatigue Syndrome (CFS) also known as Chronic Fatigue Immune Dysfunction Syndrome (CFIDS) as well as Myalgic Encephalomyelitis (ME). According to the NCF, a subgroup of patients with CFS fit a unique disease profile based on a model for a radioactive toxin.

21 Aug 2010

Low testosterone levels to blame for low libido, fatigue and weight gain

While most frequently associated with women's health, age-related hormone changes, often dubbed menopause, can occur in men as well, causing symptoms of fatigue, mood swings, decreased desire for sex, hair loss, lack of concentration and weight gain. Experts estimate that more than 5 million men are affected, yet worry the number may be considerably higher since symptoms are frequently ignored.

21 Aug 2010

U.S. boosts aid relief to Pakistani flood victims; U.N. donors meet about funding

Sen. John Kerry (D-Mass.) visited Pakistan on Thursday "to assess the damage and relief efforts" as flooding continues and millions remain in need of humanitarian aid, the New York Times reports. According to the newspaper, Kerry "said the United States would increase its flood aid to $150 million" (Masood/Gall, 8/19).

20 Aug 2010

Study finds black women with SLE develop cardiovascular disease at early age

A recent study by researchers at Penn State College of Medicine found significant racial disparities in the age of systemic lupus erythematosus (SLE) patients at the time of hospital admission for cardiovascular disease (CVD) events and CVD-related death. Black women were youngest to both be admitted with CVD and to have an in-hospital death due to CVD.

20 Aug 2010

Chelsea Therapeutics announces new investigator to conduct phase II clinical study of Droxidopa

Chelsea Therapeutics International, Ltd. announced that a new investigator-led phase II clinical study of Droxidopa, an oral synthetic precursor of norepinephrine, has been initiated in chronic fatigue syndrome (CFS).

20 Aug 2010

Concern about slow pace of aid for Pakistan mounts as U.N. secures additional funds

U.N. officials and aid groups "expressed alarm on Tuesday that the plight of millions of Pakistanis flooded from their land has yet to strike a sufficiently sympathetic nerve among donors - neither governments nor the general public - with aid trickling in far more slowly than needed," the New York Times reports.

19 Aug 2010

World Bank to provide $900M in emergency funding for Pakistan floods, country's High Commissioner provides rough damage estimate

The World Bank on Monday "pledged to reroute money from other projects to provide $900 million in emergency funding to help Pakistan" with its flood recovery efforts, the New York Times reports (Ellick, 8/17).

18 Aug 2010

Human muscles waste away on long duration space flights

Astronaut muscles waste away on long space flights reducing their capacity for physical work by more than 40%, according to research published online in the Journal of Physiology.

18 Aug 2010

Knowing allergy triggers allows sufferers to practice avoidance measures

If you spend August sneezing, ragweed may be your allergy enemy. If, like clockwork, you suffer in the spring, tree pollen may be to blame. And if your eyes itch and head feels stuffed up after the first frost should have killed every outdoor allergen, you may have indoor allergies.

17 Aug 2010

Deconstruction of biomedical research on pain will improve diagnosis, treatment of chronic pain sufferers

Is the science of diagnosing pain causing a number of pain sufferers to defend their honor? Research out of the University of Cincinnati is examining the diagnosis of pain that evades scientific testing, and the additional emotional suffering that can result for the patient.

17 Aug 2010

Natick VNA offers checklist to help patients make informed choice of home health care provider

Home from the hospital already? As stays for hospital patients grow progressively shorter, even for procedures as serious as repairing a brain aneurysm or inserting a pacemaker, patients' need for highly skilled nursing care at home is growing. Indeed, every week, thousands of these patients are referred to home health care services.

17 Aug 2010

Experimental drug benefits women with advanced ovarian or breast tumours caused by BRCA gene faults

An experimental drug called olaparib has been shown to shrink tumours in women whose advanced cancers were caused by faults in their BRCA genes.

17 Aug 2010

Georgetown researcher recommends more publication on chronic sinusitis

Facial pain. Nasal congestion. Postnasal drip. Fatigue. These are hallmark signs of chronic sinusitis, a swelling of tissue in the nasal and sinus cavity. The illness strikes millions of Americans each year and is one of the top five reasons patients visit their primary care doctor. Treating sinusitis is difficult in part because it's often not known if the cause is viral or bacterial. Unfortunately little information on the subject is available to internists says a new study by a Georgetown University Medical Center (GUMC) internist.

16 Aug 2010

Fatigue News and Research

FDA denies accelerated approval of Genentech's trastuzumab-DM1 (T-DM1) BLA for metastatic breast cancer

New vibration technology to reduce stubborn stomach fat

Treating metastatic melanoma tumors with specific genetic signature shows promising results

PLX4032 therapy results in tumor shrinkage in metastatic melanoma patients

Gatherer Partnership to advance patient rehabilitation, conditioning techniques

Epilepsy Therapy Project, EF announce recipients of New Therapy Grants Program

Researchers find gene sequences of MLV in chronic fatigue syndrome patients' blood samples

NCF announces formal disease model for Chronic Fatigue Syndrome

Low testosterone levels to blame for low libido, fatigue and weight gain

U.S. boosts aid relief to Pakistani flood victims; U.N. donors meet about funding

Study finds black women with SLE develop cardiovascular disease at early age

Chelsea Therapeutics announces new investigator to conduct phase II clinical study of Droxidopa

Concern about slow pace of aid for Pakistan mounts as U.N. secures additional funds

World Bank to provide $900M in emergency funding for Pakistan floods, country's High Commissioner provides rough damage estimate

Human muscles waste away on long duration space flights

Knowing allergy triggers allows sufferers to practice avoidance measures

Deconstruction of biomedical research on pain will improve diagnosis, treatment of chronic pain sufferers

Natick VNA offers checklist to help patients make informed choice of home health care provider

Experimental drug benefits women with advanced ovarian or breast tumours caused by BRCA gene faults

Georgetown researcher recommends more publication on chronic sinusitis

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