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UCLA announces participation in a phase 3 trial evaluating tecovirimat for the treatment of monkeypox

The UCLA Clinical AIDS Research and Education (CARE) Center today announced its participation in STOMP (Study of Tecovirimat for Human Monkeypox Virus), or A5418, a phase 3, randomized, placebo-controlled, double-blind trial evaluating the safety and efficacy of tecovirimat for the treatment of human monkeypox.

16 Sep 2022

Single-cell RNA sequencing reveals dynamic immune landscape during the early stages of bubonic plague

This study is led by Dr. Ruifu Yang, Dr. Zongmin Du (State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology) and Dr. Fan Bai (Biomedical Pioneering Innovation Center, School of Life Sciences, Peking University).

16 Sep 2022

Study may lead to a new way for treating children with eosinophilic esophagitis

A groundbreaking study from Ann & Robert H. Lurie Children's Hospital of Chicago determined the threshold for a new measure of early scarring in the esophagus of children with eosinophilic esophagitis (EoE), which allows immediate intervention during endoscopy to halt further damage and prevent food from getting stuck in the esophagus (feeding tube) of kids with this condition.

16 Sep 2022

Study investigates the link between protein intake and skeletal muscle mass in kidney transplant recipients

Conventional wisdom holds that low protein intake is essential for kidney disease patients. However, scientists from Osaka Metropolitan University demonstrated that it might not always be the case with their recent study on the relationship between protein intake and skeletal muscle mass in kidney transplant recipients.

16 Sep 2022

Lab experiments add further evidence to the bradykinin storm theory of COVID-19’s viral pathogenesis

A new paper published in Nature Communications adds further evidence to the bradykinin storm theory of COVID-19's viral pathogenesis - a theory that was posited two years ago by a team of researchers at the Department of Energy's Oak Ridge National Laboratory.

16 Sep 2022

UW Medicine researchers seek participants for Phase 3 clinical trial of a drug to treat monkeypox

UW Medicine researchers are recruiting participants for a Phase 3 clinical trial of a drug to treat the monkeypox virus.

16 Sep 2022

Excessive smartphone use may lead to early puberty

Exposure to blue light via regular use of tablets and smartphones may alter hormone levels and increase the risk of earlier puberty, according to data from a rat study presented today at the 60th Annual European Society for Paediatric Endocrinology Meeting.

16 Sep 2022

Nutritional approaches targeting gut microbiome could improve brain disorders

A new review published in the Clinical Nutrition and Metabolic Care journal focused on studies that utilized the dietary gut microbiota–target interventions to improve mental health conditions. It also discussed some suggestions for developing more robust and informative interventions for diet–microbiome studies.

15 Sep 2022

Gut microbiome associated with multiple sclerosis risk and disease development

An international research consortium led by UC San Francisco scientists has shown significant differences between the gut bacteria profiles of multiple sclerosis (MS) patients and healthy individuals, as well as between MS patients receiving different drug treatments.

15 Sep 2022

New immunotherapy approach may lead to an effective treatment for fibrosis

Chronic diseases often lead to fibrosis, a condition in which organ tissue suffers from excessive scarring.

15 Sep 2022

Customized bivalent mRNA COVID boosters protect against BA.5 Omicron variant

In a recent study posted to the bioRxiv* pre-print server, researchers from Washington University School of Medicine, Moderna, Inc, and the U.S. National Institutes of Health tested two bivalent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines based on the messenger ribonucleic acid (mRNA) platform.

14 Sep 2022

Neisseria species are linked to worsening bronchiectasis in patients, study shows

A team of international scientists led by the Nanyang Technological University, Singapore (NTU Singapore) has discovered that Neisseria - a genus of bacteria that lives in the human body - is not as harmless as previously thought, and can cause infections in patients with bronchiectasis, asthma, and chronic obstructive pulmonary disease (COPD).

14 Sep 2022

Experts question the role of white mulberry in the death of Congressman’s wife

Scientists, doctors, and pathologists are questioning the Sacramento County coroner's conclusion that Lori McClintock's death was related to white mulberry, a plant that has been used as an herbal remedy for centuries — and one that the coroner's botanical consultant called "not toxic" in a letter to her office.

14 Sep 2022

Scientists identify two distinct subtypes of obesity

A team led by Van Andel Institute scientists has identified two distinct types of obesity with physiological and molecular differences that may have lifelong consequences for health, disease and response to medication.

14 Sep 2022

SARS-CoV-2 viral infection is associated with an increased risk of Alzheimer’s disease

Older people who were infected with COVID-19 show a substantially higher risk - as much as 50% to 80% higher than a control group - of developing Alzheimer's disease within a year, according to a study of more than 6 million patients 65 and older.

14 Sep 2022

Parenteral-prime mucosal boost an effective strategy to protect against SARS-CoV-2

In a recent study published in the journal eBioMedicine, researchers in Denmark and Sweden administered a cationic liposome-adjuvanted severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein subunit vaccine as a subcutaneous (s.c.) prime-intranasal (i.n.) boost strategy to elicit mucosal immune responses among SARS-CoV-2-infected Syrian hamsters.

14 Sep 2022

First-of-its-kind messenger RNA therapy developed for ovarian cancer, cachexia

Researchers at Oregon State University and Oregon Health & Science University have developed a promising, first-of-its-kind messenger RNA therapy for ovarian cancer as well as cachexia, a muscle-wasting condition associated with cancer and other chronic illnesses.

13 Sep 2022

Altered T-cell response in hemodialysis patients following third COVID-19 vaccine dose

Scientists define the immune responses against COVID-19 in HD patients who received three mRNA COVID-19 vaccine doses.

13 Sep 2022

Review highlights the role of retinol-binding protein-4 in non-alcoholic fatty liver disease

It is a known fact that consuming a large amount of alcohol, even for a few days, triggers fat accumulation in the liver and ultimately leads to alcohol-related liver diseases.

13 Sep 2022

Experimental drug prolongs survival, improves muscle function in mice severe Duchenne muscular dystrophy

Researchers at Johns Hopkins Medicine report that an experimental drug first developed to treat kidney disease prolongs survival and improves muscle function in mice genetically engineered to develop a severe form of Duchenne muscular dystrophy (DMD).

13 Sep 2022

Inflammation News and Research

UCLA announces participation in a phase 3 trial evaluating tecovirimat for the treatment of monkeypox

Single-cell RNA sequencing reveals dynamic immune landscape during the early stages of bubonic plague

Study may lead to a new way for treating children with eosinophilic esophagitis

Study investigates the link between protein intake and skeletal muscle mass in kidney transplant recipients

Lab experiments add further evidence to the bradykinin storm theory of COVID-19’s viral pathogenesis

UW Medicine researchers seek participants for Phase 3 clinical trial of a drug to treat monkeypox

Excessive smartphone use may lead to early puberty

Nutritional approaches targeting gut microbiome could improve brain disorders

Gut microbiome associated with multiple sclerosis risk and disease development

New immunotherapy approach may lead to an effective treatment for fibrosis

Customized bivalent mRNA COVID boosters protect against BA.5 Omicron variant

Neisseria species are linked to worsening bronchiectasis in patients, study shows

Experts question the role of white mulberry in the death of Congressman’s wife

Scientists identify two distinct subtypes of obesity

SARS-CoV-2 viral infection is associated with an increased risk of Alzheimer’s disease

Parenteral-prime mucosal boost an effective strategy to protect against SARS-CoV-2

First-of-its-kind messenger RNA therapy developed for ovarian cancer, cachexia

Altered T-cell response in hemodialysis patients following third COVID-19 vaccine dose

Review highlights the role of retinol-binding protein-4 in non-alcoholic fatty liver disease

Experimental drug prolongs survival, improves muscle function in mice severe Duchenne muscular dystrophy

Industry Focus eBook - Neurology/Neuroscience - 2nd edition eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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