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Unlocking sulfasalazine's mechanism of action in IBD-SpA patients

Although it is one of the oldest medications used to treat patients with inflammatory bowel disease (IBD) and an effective treatment for an associated arthritis condition called spondyloarthritis (SpA), sulfasalazine's mechanism of action has been unclear.

20 Feb 2024

Aging alters fibroblasts to promote pancreatic cancer growth

Older people may be at greater risk of developing pancreatic cancer and have poorer prognoses because of age-related changes in cells in the pancreas called fibroblasts, according to research led by investigators from the Johns Hopkins Kimmel Cancer Center, the Johns Hopkins Bloomberg School of Public Health and the Bloomberg~Kimmel Institute for Cancer Immunotherapy.

20 Feb 2024

Investigating dosage in hyperbaric oxygen therapy for post-covid conditions

Hyperbaric oxygen therapy, giving patients 100 percent oxygen at a pressure corresponding to 10-20 meters below sea level, has been around for almost 100 years.

20 Feb 2024

Novel therapy harnesses stem cell-derived exosomes for diabetic wound healing

Researchers unveiled a novel therapy for diabetic wound healing. This research highlights the use of exosomal miR-4645-5p from hypoxic bone marrow mesenchymal stem cells (BMSCs) to significantly enhance wound healing by promoting keratinocyte autophagy.

20 Feb 2024

Study proposes novel approach to slow neuromuscular degeneration in ALS patients

A study led by the Center for Biomaterials and Tissue Engineering of the Universitat Politècnica de València, member of Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine, in collaboration with the Instituto de Investigación Sanitaria La Fe and the University of Zaragoza proposes a novel approach to slow neuromuscular degeneration in patients with Amyotrophic Lateral Sclerosis.

20 Feb 2024

Breakthrough gene therapy method utilizes bird retrotransposon for safe gene insertion

The recent approval of a CRISPR-Cas9 therapy for sickle cell disease demonstrates that gene editing tools can do a superb job knocking out genes to cure hereditary disease.

20 Feb 2024

MIP Discovery closes £7M Series A financing to drive commercialization in cell and gene therapy space

Company’s synthetic affinity reagents are antibody alternatives designed to advance the speed, safety, and efficiency of manufacturing at scale, making advanced therapies more accessible to patients.

From MIP Discovery 20 Feb 2024

Researchers develop novel nanomedicine loaded with genetic material to fight HIV

Society learned about the value of mRNA during the COVID-19 pandemic when we saw scientists and medical professionals harness its power to deliver a vaccine for the virus within a year.

20 Feb 2024

Increased risk of autoimmune disease after Cushing's disease remission

A study of more than 250 persons undergoing surgical therapy for Cushing's disease (CD) or nonfunctioning pituitary adenomas (NFPAs) found that patients who achieved remission of CD were more likely than those with surgically treated NFPAs to develop new-onset autoimmune disease within 3 years after remission.

19 Feb 2024

Sleep-circadian disturbances can trigger or worsen a range of psychiatric disorders

Problems with our sleep and internal body clock can trigger or worsen a range of psychiatric disorders, according to a new review of recent research evidence.

19 Feb 2024

New RNA therapy zilebesiran shows promise in lowering blood pressure

Zilebesiran, an RNA interference therapeutic, significantly reduces blood pressure in hypertension patients with a favorable safety profile, offering a potential biannual treatment option.

19 Feb 2024

What factors are associated with recent prostate-specific antigen screening in transgender women?

A new study reports on factors associated with prostate cancer screening among transgender women.

19 Feb 2024

Single-dose genetic medicine halts the progression of ALS and frontotemporal dementia in mice

Neuroscientists at Macquarie University in Australia have developed a single-dose genetic medicine that has been proven to halt the progression of both ALS and frontotemporal dementia (FTD) in mice – and may even offer the potential to reverse some of the effects of the fatal diseases.

19 Feb 2024

FDA approves omalizumab for food allergy reactions based on NIH research

Today's Food and Drug Administration approval of a supplemental biologics license for the monoclonal antibody omalizumab (Xolair) highlights the vital role of the National Institutes of Health-supported research that underpins the FDA decision.

16 Feb 2024

Innovative immunotherapy targets rare melanoma subtypes

Scientists at the UCLA Health Jonsson Comprehensive Cancer Center have built and demonstrated the potential efficacy of a new chimeric antigen receptor (CAR) T-cell-based immunotherapy specifically designed to treat patients with cutaneous and rare subtypes of melanoma.

16 Feb 2024

Neoadjuvant chemotherapy shows promise for advanced penile cancer

Penile squamous cell carcinoma is a rare malignancy with limited treatment options and poor prognosis, especially in advanced stages. Because of its rarity, few studies focus on better understanding and managing this disease.

16 Feb 2024

Study suggests patients with severe long COVID present with variable symptoms, do not cluster in relation to organs affected or immunological states

A new preprint reports significantly associated findings that may help predict severe long COVID and understand what causes it.

16 Feb 2024

Exercise is an effective treatment for depression, with walking, jogging, yoga, and strength training more effective than other exercises

Researchers determined the potentially most effective exercise regimen and dosage in managing major depressive disorder in comparison to antidepressants, psychotherapy, and control interventions.

16 Feb 2024

Study suggests CT imaging with automated AI system predicts EGFR genotype, identifying mutation status cost-effectively and non-invasively

Researchers developed an artificial intelligence (AI)-based predictive system (AIPS) model for the early detection of lung cancer by combining radiological, clinical, and genetic data.

16 Feb 2024

Transforming Cancer Care: Aventa Genomics and the Future of Genomic Testing

In this interview, Chris Roberts of Aventa Genomics highlights the groundbreaking Aventa FusionPlus test, detailing its superior ability to detect gene fusions in cancer diagnostics and its pivotal role in advancing personalized oncology treatments.

From Aventa Genomics 16 Feb 2024

Therapy News and Research

Unlocking sulfasalazine's mechanism of action in IBD-SpA patients

Aging alters fibroblasts to promote pancreatic cancer growth

Investigating dosage in hyperbaric oxygen therapy for post-covid conditions

Novel therapy harnesses stem cell-derived exosomes for diabetic wound healing

Study proposes novel approach to slow neuromuscular degeneration in ALS patients

Breakthrough gene therapy method utilizes bird retrotransposon for safe gene insertion

MIP Discovery closes £7M Series A financing to drive commercialization in cell and gene therapy space

Researchers develop novel nanomedicine loaded with genetic material to fight HIV

Increased risk of autoimmune disease after Cushing's disease remission

Sleep-circadian disturbances can trigger or worsen a range of psychiatric disorders

New RNA therapy zilebesiran shows promise in lowering blood pressure

What factors are associated with recent prostate-specific antigen screening in transgender women?

Single-dose genetic medicine halts the progression of ALS and frontotemporal dementia in mice

FDA approves omalizumab for food allergy reactions based on NIH research

Innovative immunotherapy targets rare melanoma subtypes

Neoadjuvant chemotherapy shows promise for advanced penile cancer

Study suggests patients with severe long COVID present with variable symptoms, do not cluster in relation to organs affected or immunological states

Exercise is an effective treatment for depression, with walking, jogging, yoga, and strength training more effective than other exercises

Study suggests CT imaging with automated AI system predicts EGFR genotype, identifying mutation status cost-effectively and non-invasively

Transforming Cancer Care: Aventa Genomics and the Future of Genomic Testing

Industry Focus eBook - Life Science Microscopy (2nd Edition) eBook

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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