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Nanotherapies may benefit preterm babies with bronchopulmonary dysplasia

Very premature babies need extra oxygen and mechanical intervention to breathe, but this damages their lungs, causing a chronic lung disease called bronchopulmonary dysplasia (BPD).

30 Mar 2022

CDK6: a potential drug target for severe COVID-19

Researchers identify a methodology and workflow to repurpose drugs against the cyclin-dependent kinase 6 target gene of SARS-CoV-2.

27 Mar 2022

Using a new data-driven approach to understand more about people with Type 1 diabetes

An interdisciplinary team of researchers from the University of Missouri, Children's Mercy Kansas City and Texas Children's Hospital has used a new data-driven approach to learn more about persons with Type 1 diabetes, who account for about 5-10% of all diabetes diagnoses.

21 Mar 2022

Recovery of consciousness may take weeks for most COVID patients on respirators

Most patients with severe COVID who are put on ventilators regain consciousness after removal of respiratory support, but recovery may take weeks after the period of mechanical ventilation has ended, according to a new study by investigators at Weill Cornell Medicine, Columbia University Vagelos College of Physicians and Surgeons, Harvard Medical School, NewYork-Presbyterian and Massachusetts General Hospital.

15 Mar 2022

High doses of antibiotic may safely and effectively treat TB meningitis

A Johns Hopkins Children's Center-led study in animals suggests that high doses of a widely used antibiotic called rifampin may safely treat and reduce the duration of treatment for the deadliest form of tuberculosis that affects the brain, potentially improving survival rates for patients and decreasing the likelihood of lasting adverse effects of the disease.

15 Mar 2022

Small airways disease is a potential long-lasting effect of COVID-19, study says

Disease of the small airways in the lungs is a potential long-lasting effect of COVID-19, according to a new study published in the journal Radiology.

15 Mar 2022

Novel genetic relationships with severe SARS-CoV-2

Researchers discovered multiple novel genetic processes underpinning severe COVID-19 using genome-wide association studies and meta-analyses.

11 Mar 2022

Genomic surveillance of bacterial colonies could help physicians keep closer tabs on drug resistance

Antibiotic-resistant bacterial infections are difficult to treat and cause more than a million annual deaths worldwide, especially in hospitalized patients with pneumonia, bloodstream infections, urinary tract infections, or abdominal infections.

11 Mar 2022

A predictive model for COVID-19 outcomes

A new technique to solve unbalanced problems for the efficient management of SARS-CoV-2 infected patients according to comorbidities, age, and sex.

9 Mar 2022

Mathematical model for evaluating factors driving SARS-CoV-2 transmission and pathogenesis

A new study provides an overview of the use of mathematical modeling to determine severe acute respiratory syndrome coronavirus 2 kinetics.

9 Mar 2022

World's largest genetic study reveals fresh details about severe Covid-19

The world's largest study of the genetics of critical Covid-19, involving more than 57,000 people, has revealed fresh details about some of the biological mechanisms behind the severe form of the disease.

7 Mar 2022

Proactive machine learning models could speed data collection and analysis in healthcare

Shifting machine learning workflows to a proactive model could speed data collection and analysis in healthcare, according to a viewpoint article published in JAMA.

3 Mar 2022

Vaccination gap in trauma patients widened even as vaccines became more widely available

Trauma patients treated and hospitalized in a Tennessee medical center had a 33% lower rate of COVID-19 vaccination than non-trauma patients who were hospitalized following treatment in the emergency department (ED).

2 Mar 2022

Study shows the viability of lung transplants in patients with COVID-19-associated ARDS

Patients with COVID-19-associated acute respiratory distress syndrome who received lung transplants had similar outcomes, compared to transplant patients without COVID-19, according to a Northwestern Medicine study published in JAMA.

2 Mar 2022

Novel mechanism that connects circadian rhythm and muscle repair discovered

Northwestern Medicine investigators have discovered a novel mechanism that connects circadian rhythm-controlled cellular metabolism and regeneration with muscle repair after injury, according to recent findings published in the journal Genes and Development.

28 Feb 2022

ECMO shortage linked to the death of young, healthy COVID-19 patients

Nearly 90 percent of COVID-19 patients who qualified for, but did not receive, ECMO (extracorporeal membrane oxygenation) due to a shortage of resources during the height of the pandemic died in the hospital, despite being young with few other health issues, according to a study published in the American Journal of Respiratory and Critical Care Medicine.

25 Feb 2022

Severe COVID-19 outcomes in breakthrough infections in patients being treated with B cell depleting therapy

Scientists evaluated the incidence and severity of breakthrough SARS-CoV-2 infections among individuals with immune-mediated inflammatory diseases undergoing B cell depleting therapy.

25 Feb 2022

Vaccinated adults were less likely to land in intensive care during the omicron surge

The highly contagious omicron variant of SARS-CoV-2 became the dominant strain in the United States in mid-December 2021, coinciding with a rise in hospitalizations of patients with COVID-19.

24 Feb 2022

Intermediate size nanoparticles may be effective at stopping internal bleeding

Traumatic injuries are the leading cause of death in the U.S. among people 45 and under, and such injuries account for more than 3 million deaths per year worldwide.

17 Feb 2022

Study finds higher mortality rates among African children and adolescents hospitalized with COVID-19

African children and adolescents hospitalized with COVID-19 experience much higher mortality rates than Europeans or North Americans of the same age, according to a recently published study conducted by researchers from the Institute of Human Virology (IHV) at the University of Maryland School of Medicine (UMSOM) and the Institute of Human Virology Nigeria (IHVN).

16 Feb 2022

Critical Care News and Research

Nanotherapies may benefit preterm babies with bronchopulmonary dysplasia

CDK6: a potential drug target for severe COVID-19

Using a new data-driven approach to understand more about people with Type 1 diabetes

Recovery of consciousness may take weeks for most COVID patients on respirators

High doses of antibiotic may safely and effectively treat TB meningitis

Small airways disease is a potential long-lasting effect of COVID-19, study says

Novel genetic relationships with severe SARS-CoV-2

Genomic surveillance of bacterial colonies could help physicians keep closer tabs on drug resistance

A predictive model for COVID-19 outcomes

Mathematical model for evaluating factors driving SARS-CoV-2 transmission and pathogenesis

World's largest genetic study reveals fresh details about severe Covid-19

Proactive machine learning models could speed data collection and analysis in healthcare

Vaccination gap in trauma patients widened even as vaccines became more widely available

Study shows the viability of lung transplants in patients with COVID-19-associated ARDS

Novel mechanism that connects circadian rhythm and muscle repair discovered

ECMO shortage linked to the death of young, healthy COVID-19 patients

Severe COVID-19 outcomes in breakthrough infections in patients being treated with B cell depleting therapy

Vaccinated adults were less likely to land in intensive care during the omicron surge

Intermediate size nanoparticles may be effective at stopping internal bleeding

Study finds higher mortality rates among African children and adolescents hospitalized with COVID-19

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