Mouse Model News and Research

RSS

PIN1 protein found to be a significant driver of bladder cancer

Like all cancers, bladder cancer develops when abnormal cells start to multiply out of control. But what if we could put a lid on their growth?

15 Jan 2025

New compounds show promise in treating retinitis pigmentosa

Two new compounds may be able to treat retinitis pigmentosa, a group of inherited eye diseases that cause blindness.

15 Jan 2025

New gene-editing treatment extends lifespan in mice with prion disease

Researchers at the Broad Institute of MIT and Harvard have developed a gene-editing treatment for prion disease that extends lifespan by about 50 percent in a mouse model of the fatal neurodegenerative condition.

15 Jan 2025

Uncovering the neurobiological mechanisms of delta opioid receptor agonists

The global burden of anxiety- and depression-related disorders is on the rise. While multiple drugs have been developed to treat these conditions, current medications have several limitations, including slow action and adverse effects with long-term use. This underscores the urgent need for novel, rapidly-acting therapeutic agents with minimal side effects.

15 Jan 2025

Inflammasome protects stem cells from becoming cancerous

A group of immune proteins called the inflammasome can help prevent blood stem cells from becoming malignant by removing certain receptors from their surfaces and blocking cancer gene activity, according to a preclinical study by Weill Cornell Medicine investigators.

13 Jan 2025

How stress fuels allergic skin inflammation

Researchers investigate the cellular and molecular mechanisms through which stress exacerbates immunoglobulin E cutaneous allergic inflammation.

9 Jan 2025

New nanoplatform combines pyroptosis and ferroptosis for enhanced cancer treatment

Photoimmunotherapy is an innovative cancer treatment that combines phototherapy with immunotherapy to selectively target and destroy cancer cells.

8 Jan 2025

Study reveals how neuropilin2 gene influences autism and epilepsy development

The gene neuropilin2 encodes a receptor involved in cell-cell interactions in the brain and plays a key role in regulating the development of neural circuits.

8 Jan 2025

Carrots may offer natural support for people with type 2 diabetes

Could an ordinary carrot improve the treatment of type 2 diabetes? A new study from SDU suggests so.

8 Jan 2025

Heart attack recovery enhanced by human stem cell spheroids, study shows

In a large-animal model study, researchers have found that heart attack recovery is aided by injection of heart muscle cell spheroids derived from human induced pluripotent stem cells, or hiPSCs, that overexpress cyclin D2 and are knocked out for human leukocyte antigen classes I and II.

7 Jan 2025

Stress-induced immune dysfunction linked to worsened skin allergies

Psychological stress is known to exacerbate skin allergies, but the underlying molecular mechanisms remain poorly understood.

7 Jan 2025

Topical immunotherapy clears precancerous skin lesions and reduces cancer risk

Calcipotriol-plus–5-FU therapy activates immune pathways, offering long-lasting protection against squamous cell carcinoma by targeting precancerous lesions.

6 Jan 2025

Scientists identify novel antibodies for fighting malaria

A novel class of antibodies that binds to a previously untargeted portion of the malaria parasite could lead to new prevention methods, according to a study from researchers at the National Institutes of Health (NIH) published today in Science.

3 Jan 2025

New immunotherapy shows long-term benefits in preventing squamous cell carcinoma

A new study by investigators from Mass General Brigham uncovers how a novel immunotherapy prevents squamous cell carcinoma, with benefits lasting five years after treatment.

2 Jan 2025

Mapping cerebellar nuclei outputs in an autism mouse model

The cerebellum plays a critical role in both motor and non-motor functions, and its dysfunction is linked to various mental disorders, including autism.

27 Dec 2024

Setd2 catalytic activity is crucial for embryonic development in mice

A recent study delves into the pivotal role of Setd2, a histone methyltransferase enzyme, in embryonic development within mice.

27 Dec 2024

New insights into the developmental trajectory of social behaviors in fragile X syndrome

In a comprehensive Genomic Press Interview, researchers from the University of Texas Health Science Center at San Antonio and Hirosaki University have uncovered critical new insights into the developmental trajectory of social behaviors in fragile X syndrome, the leading genetic cause of autism spectrum disorder.

24 Dec 2024

Professor Inga Neumann advances understanding of oxytocin and social fear

In a comprehensive Genomic Press Interview, Professor Inga Neumann, Chair of the Department of Behavioural and Molecular Neurobiology at the University of Regensburg, reveals groundbreaking insights into how oxytocin shapes social behavior and emotional responses in the brain.

24 Dec 2024

SPLICER shows promise in Alzheimer's and other diseases

A new gene editing tool that helps cellular machinery skip parts of genes responsible for diseases has been applied to reduce the formation of amyloid-beta plaque precursors in a mouse model of Alzheimer's disease, researchers at the University of Illinois Urbana-Champaign report.

23 Dec 2024