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Janssen reports positive pivotal Phase 2 study data of siltuximab for Multicentric Castleman's Disease

Janssen Research & Development, LLC today announced positive results from a pivotal Phase 2 global registration study (MCD2001) suggesting siltuximab, an investigational compound, along with best supportive care, exhibited statistically significant efficacy and a tolerable safety profile compared with placebo and BSC in treating patients with the rare disorder Multicentric Castleman's Disease who are HIV-negative and human herpes virus 8-negative.

8 Dec 2013

Scientists test affected human nerve cells to foretell efficacy of Alzheimer drugs

Why do certain Alzheimer medications work in animal models but not in clinical trials in humans? A research team from the University of Bonn and the biomedical enterprise LIFE & BRAIN GmbH has been able to show that results of established test methods with animal models and cell lines used up until now can hardly be translated to the processes in the human brain. Drug testing should therefore be conducted with human nerve cells, conclude the scientists.

6 Dec 2013

Researchers update extensive toxicology database to track information about drugs toxic effects

Sometimes the cure can be worse than the disease. Pharmaceutical drugs are known for their potential side effects, and an important aspect of personalized medicine is to tailor therapies to individuals to reduce the chances of adverse events.

6 Dec 2013

Study reports new links between brain cell activity and choices where two options have equal appeal

Life presents us with choices all the time: salad or pizza for lunch? Tea or coffee afterward? How we make these everyday decisions has been a topic of great interest to economists, who have devised theories about how we assign values to our options and use those values to make decisions.

6 Dec 2013

Scientists receive 2013 Louisa Gross Horwitz Prize for advancements in field of neuroscience

For discoveries about how the brain calculates and remembers where it is—which could be part of the foundation of memory—Columbia University will award the 2013 Louisa Gross Horwitz Prize to Edvard I. Moser, PhD, and May-Britt Moser, PhD, of the Norwegian University of Science and Technology in Norway, and John Michael O'Keefe, PhD, of University College London in the UK.

6 Dec 2013

Biologists discover how nerve cells recycle tiny vesicles

University of Utah and German biologists discovered how nerve cells recycle tiny bubbles or "vesicles" that send chemical nerve signals from one cell to the next. The process is much faster and different than two previously proposed mechanisms for recycling the bubbles.

5 Dec 2013

St. Jude Medical evaluates effectiveness of PNfS and SCS for chronic low back and leg pain

St. Jude Medical, Inc., a global medical device company, has launched a clinical study to evaluate the combination of peripheral nerve field stimulation, and spinal cord stimulation, to determine whether the two therapies together offer more effective management of chronic low back and leg pain than SCS alone. The first patient in the SENSE Subcutaneous and Epidural Neuromodulation System Evaluation study was enrolled by Dr. Thomas Yearwood, an interventional pain physician at Comprehensive Pain & Rehabilitation in Pascagoula, Miss.

5 Dec 2013

Researchers present new method of wirelessly recharging medical device batteries with ultrasound

Human beings don't come with power sockets, but a growing numbers of us have medical implants that run off electricity. To keep our bionic body parts from powering down, a group of Arizona researchers is developing a safe, noninvasive, and efficient means of wireless power transmission through body tissue.

5 Dec 2013

Stomach circadian clock limits food intake to specific times of day

University of Adelaide researchers have discovered the first evidence that the nerves in the stomach act as a circadian clock, limiting food intake to specific times of the day.

5 Dec 2013

TYRX receives FDA clearance to market AIGISRx N Antibacterial Envelope

TYRX, Inc. announced today that it has received U.S. Food and Drug Administration clearance for expanded indications in marketing the AIGISRx N Antibacterial Envelope for use with spinal cord neuromodulators.

5 Dec 2013

New research offers fresh insights to drug designers searching for better pain treatments

In a technical tour de force, UC San Francisco scientists have determined, at near-atomic resolution, the structure of a protein that plays a central role in the perception of pain and heat.

5 Dec 2013

Update on reimbursement coverage for Percutaneous Tibial Nerve Stimulation procedures

Uroplasty, Inc. a medical device company that develops, manufactures and markets innovative proprietary products for the treatment of voiding dysfunctions, today provided an update on reimbursement coverage for Percutaneous Tibial Nerve Stimulation (PTNS) procedures delivered via the Company's Urgent® PC Neuromodulation System for treatment of overactive bladder (OAB) and associated symptoms of urinary urgency, urinary frequency and urge incontinence.

4 Dec 2013

Sympathetic skin response test assesses autonomic nerve functions in patients with spinal cord injury

Neurological functions following spinal cord injury have generally been assessed using the American Spinal Injury Association (ASIA) impairment scale.

4 Dec 2013

Finding identifies new mechanism that could contribute to the pathology of ALS

RNA molecules, used by cells to make proteins, are generally thought to be "silent" when stowed in cytoplasmic granules. But a protein mutated in some ALS patients forms granules that permit translation of stored RNAs, according to a study in The Journal of Cell Biology. The finding identifies a new mechanism that could contribute to the pathology of the disease.

4 Dec 2013

Newly discovered receptor may help in early diagnosis and treatment for sepsis

Sepsis, or septicaemia, is a devastating disease that is difficult to diagnose early and for which treatment options are limited. The number of deaths from sepsis exceeds those from lung cancer, and from breast and bowel cancer combined.

4 Dec 2013

Young athletes are more prone to hip impingement, say specialists

Hip pain is no longer reserved for older adults. More and more young, active people are developing this problem, which often requires surgery to repair.

4 Dec 2013

Gladstone scientist devise new molecular sensor that can detect MS at earliest stages

For some, the disease multiple sclerosis attacks its victims slowly and progressively over a period of many years. For others, it strikes without warning in fits and starts. But all patients share one thing in common: the disease had long been present in their nervous systems, hiding under the radar from even the most sophisticated detection methods. But now, scientists at the Gladstone Institutes have devised a new molecular sensor that can detect MS at its earliest stages-even before the onset of physical signs.

3 Dec 2013

Scientists identify enzyme that could lead to better treatment of Alzheimer's disease

St. Jude Children's Research Hospital scientists have identified an enzyme that can halt or possibly even reverse the build-up of toxic protein fragments known as plaques in the brains of mice with Alzheimer's disease. The research appeared in a recent edition of the scientific journal Nature Communications.

3 Dec 2013

Bariatric surgery can potentially reverse type 2 diabetes

Although obesity is a notoriously difficult disease to treat conservatively, there is hope. Board-certified bariatric surgeon Michael Feiz, MD, FACS recommends weight loss surgery as a solution for morbidly obese adults who want to get healthy once and for all.

3 Dec 2013

Computer models of neuronal sound processing in brain lead to cochlear implant improvements

Intact hearing is a prerequisite for learning to speak. This is why children who are born deaf are fitted with so-called cochlear implants as early as possible. Cochlear implants consist of a speech processor and a transmitter coil worn behind the ear, together with the actual implant, an encapsulated microprocessor placed under the skin to directly stimulate the auditory nerve via an electrode with up to 22 contacts.

3 Dec 2013

Nerve News and Research

Janssen reports positive pivotal Phase 2 study data of siltuximab for Multicentric Castleman's Disease

Scientists test affected human nerve cells to foretell efficacy of Alzheimer drugs

Researchers update extensive toxicology database to track information about drugs toxic effects

Study reports new links between brain cell activity and choices where two options have equal appeal

Scientists receive 2013 Louisa Gross Horwitz Prize for advancements in field of neuroscience

Biologists discover how nerve cells recycle tiny vesicles

St. Jude Medical evaluates effectiveness of PNfS and SCS for chronic low back and leg pain

Researchers present new method of wirelessly recharging medical device batteries with ultrasound

Stomach circadian clock limits food intake to specific times of day

TYRX receives FDA clearance to market AIGISRx N Antibacterial Envelope

New research offers fresh insights to drug designers searching for better pain treatments

Update on reimbursement coverage for Percutaneous Tibial Nerve Stimulation procedures

Sympathetic skin response test assesses autonomic nerve functions in patients with spinal cord injury

Finding identifies new mechanism that could contribute to the pathology of ALS

Newly discovered receptor may help in early diagnosis and treatment for sepsis

Young athletes are more prone to hip impingement, say specialists

Gladstone scientist devise new molecular sensor that can detect MS at earliest stages

Scientists identify enzyme that could lead to better treatment of Alzheimer's disease

Bariatric surgery can potentially reverse type 2 diabetes

Computer models of neuronal sound processing in brain lead to cochlear implant improvements

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

How microplastics and bacteria interact to drive antibiotic resistance

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