B Cell News and Research

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St. Jude Medical receives approval of first extended-life primary cell neurostimulator for treatment of chronic pain

St. Jude Medical, Inc. has announced U.S. Food and Drug Administration (FDA) and European CE Mark approvals of EonC, the first extended-life primary cell (non-rechargeable) neurostimulator for the treatment of chronic pain.

13 Aug 2008

Molecular switch provides insights into a form of altered brain activity occurring in schizophrenia

People with schizophrenia have an alteration in a pattern of brain electrical activity associated with learning and memory. Now, researchers from the National Institutes of Health and Sweden's Karolinska Institute have identified in mouse brain tissue a molecular switch that, when thrown, increases the strength of this electrical pattern. The researchers found that adding the brain chemical Neuregulin-1 to the brain tissue boosted the electrical signals that the tissue generated.

13 Aug 2008

A snooze button for the circadian clock

We may use the snooze button to fine-tune our sleep cycles, but our cells have a far more meticulous and refined system. Humans, and most other organisms, have 24-hour rhythms that are regulated by a precise molecular clock that ticks inside every cell.

13 Aug 2008

Experimental chemo shows promise in treating advanced non-small cell lung cancer

A combination of chemotherapy agents that have been tested in other tumor types appears to be a promising alternative to standard treatment for advanced non-small cell lung cancer, according to a report in the August 15 issue of Clinical Cancer Research, a journal of the American Association for Cancer Research.

12 Aug 2008

Rare case explains why some infected with HIV remain symptom free without antiretroviral drugs

AIDS experts at Johns Hopkins say they have compelling evidence that some people with HIV who for years and even decades show extremely low levels of the virus in their blood never progress to full-blown AIDS and remain symptom free even without treatment, probably do so because of the strength of their immune systems, not any defects in the strain of HIV that infected them in the first place.

12 Aug 2008

Virginia Hospital Center to launch $14 million new hospital information system

Virginia Hospital Center will launch a $14 million new Hospital Information System (HIS) in 2009 that will utilize advanced information technologies (IT) to create efficiencies and orchestrate clinical best practices. The Hospital signed an agreement with Siemens Medical Solutions and will implement its powerful workflow-engineered health information solution, Soarian.

12 Aug 2008

Medulloblastoma in children - two studies find clues to treatment

Medulloblastoma is one of the most common and most malignant brain tumours among children and teenagers. These tumours grow very rapidly, and fifty percent of patients in the long term die from the condition. The details of the processes that lead to the growth of these tumours have remained unknown until now.

12 Aug 2008

Ruthenium used to sucker punch cancer

Chemists are pulling cancer onto a sucker punch by getting infected cells to drop their guard - according to research published today. They are using the metal ruthenium as a catalyst to a cancer-busting reaction which calls up an old cellular enemy - oxidants - as an ally.

12 Aug 2008

NCI awards Wilmot scientists $1.6 million to study lymphoma treatments

The National Cancer Institute has tapped a team of scientists at the James P. Wilmot Cancer Center to lead a $1.6 million in research program to improve lymphoma treatment, an area of excellence in research and care for the University of Rochester Medical Center.

12 Aug 2008

MicroRNAs help control blood-vessel development

The development and repair of heart tissue and blood vessels is intimately tied to a tiny piece of ribonucleic acid (RNA) that is found nowhere else in the body, researchers at UT Southwestern Medical Center have found.

12 Aug 2008

Australian researchers reveal how cancers become more aggressive

A team of Australian scientists have discovered how some cancers are able to mutate into more aggressive and potentially fatal cancers in the human body.

11 Aug 2008

Researchers identify molecular mechanism underlying a genetic brain malformation called holoprosencephaly

St. Jude Children's Research Hospital scientists have identified one of the molecular mechanisms underlying the genetic brain malformation called holoprosencephaly (HPE).

11 Aug 2008

Scientists identify microRNA that controls blood vessel development - therapeutic target for a number of diseases

Scientists from the Gladstone Institute of Cardiovascular Disease (GICD) and UCSF have identified a key regulatory factor that controls development of the human vascular system, the extensive network of arteries, veins, and capillaries that allow blood to reach all tissues and organs.

11 Aug 2008

Newly discovered molecular switch creates new path to study birth defects and cancer

Researchers have discovered a central molecular switch in fruit fly embryos that opens new avenues for studying the causes of birth defects and cancer in humans.

11 Aug 2008

Finding cancer's original cell key to treatments

Cancer biologists are turning their attention to the normal cells that give rise to cancers, to learn more about how tumor growth might be stopped at the earliest opportunity.

11 Aug 2008

Cancer survival secrets discovered by Australian researchers

A team of Monash University researchers has uncovered the role of a family of enzymes in the mutation of benign or less aggressive tumours into more aggressive, potentially fatal, cancers in the human body.

11 Aug 2008

Medulloblastoma originates in normal brain "stem" cells that turn malignant

An aggressive childhood brain tumor known as medulloblastoma originates in normal brain "stem" cells that turn malignant when acted on by a known mutant, cancer-causing oncogene, say researchers from Dana-Farber Cancer Institute and the University of California, San Francisco (UCSF).

11 Aug 2008

Scientists discover reservoir of mitochondrial DNA mutations present in the general population

Researchers at the University of Newcastle, England, and the Virginia Bioinformatics Institute at Virginia Tech in the United States have revealed a large reservoir of mitochondrial DNA mutations present in the general population. Clinical analysis of blood samples from almost 3,000 infants born in north Cumbria, England, showed that at least 1 in 200 individuals in the general public harbor mitochondrial DNA mutations that may lead to disease.

11 Aug 2008

Low vitamin D levels substantially increase risk of death

Researchers at Johns Hopkins are reporting what is believed to be the most conclusive evidence to date that inadequate levels of vitamin D, obtained from milk, fortified cereals and exposure to sunlight, lead to substantially increased risk of death.

11 Aug 2008

Designer RNA fights high cholesterol, medical researchers find

Small, specially designed bits of ribonucleic acid (RNA) can interfere with cholesterol metabolism, reducing harmful cholesterol by two-thirds in pre-clinical tests, according to a new study by researchers at UT Southwestern Medical Center in collaboration with Alnylam Pharmaceuticals and the Massachusetts Institute of Technology.

11 Aug 2008

B Cell News and Research

St. Jude Medical receives approval of first extended-life primary cell neurostimulator for treatment of chronic pain

Molecular switch provides insights into a form of altered brain activity occurring in schizophrenia

A snooze button for the circadian clock

Experimental chemo shows promise in treating advanced non-small cell lung cancer

Rare case explains why some infected with HIV remain symptom free without antiretroviral drugs

Virginia Hospital Center to launch $14 million new hospital information system

Medulloblastoma in children - two studies find clues to treatment

Ruthenium used to sucker punch cancer

NCI awards Wilmot scientists $1.6 million to study lymphoma treatments

MicroRNAs help control blood-vessel development

Australian researchers reveal how cancers become more aggressive

Researchers identify molecular mechanism underlying a genetic brain malformation called holoprosencephaly

Scientists identify microRNA that controls blood vessel development - therapeutic target for a number of diseases

Newly discovered molecular switch creates new path to study birth defects and cancer

Finding cancer's original cell key to treatments

Cancer survival secrets discovered by Australian researchers

Medulloblastoma originates in normal brain "stem" cells that turn malignant

Scientists discover reservoir of mitochondrial DNA mutations present in the general population

Low vitamin D levels substantially increase risk of death

Designer RNA fights high cholesterol, medical researchers find

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