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Restricting consumption of high-sucrose diet to active part of day avoids adverse effects in rats

A sedentary lifestyle combined with a diet dominated by processed foods has widely resulted in a range of conditions including diabetes, obesity, and high blood pressure, which are known collectively as metabolic syndrome.

27 Aug 2018

Newly discovered target may prevent progression of liver injury to cancer

Problems like obesity and alcoholism appear to chronically trigger in the liver a receptor known to amplify inflammation in response to invaders like bacteria, scientists report.

27 Aug 2018

Very high levels of good cholesterol may increase risk of heart attack and death

Very high levels of high-density lipoprotein cholesterol may be associated with an increased risk of heart attack and death, according to research presented today at ESC Congress 2018.

25 Aug 2018

Surgeons test new device that keeps the liver warm and circulates blood during transport

Since the first liver transplant in 1963, donated livers have been immersed in an icy cold fluid in a cold storage system for transport, similar in principle to ice chests used for picnics and trips to the beach.

25 Aug 2018

Genetic interindividual variability influences nutritional requirements

Approximately 0.1%: that is the average genetic difference between two individuals. This small percentage is responsible for the variations of certain physical traits, such as eyes, hair, and height, but also for differences in our susceptibility to certain diseases and our capacity to absorb vitamins and phytomicronutrients, involved in the prevention of chronic disease.

24 Aug 2018

Fresh and raw diets may provide benefits for dogs, study finds

Many dog owners think of their furry companions as part of the family, and now products are available to feed them that way, too.

24 Aug 2018

Alcohol in any amount harmful finds study

A large study has shown that abstaining completely from alcohol is the best way to protect from the harm it may cause. There have been previous studies that have shown that around one drink a day for women and two for men could be beneficial for protection against heart disease. This new study debunks that idea.

23 Aug 2018

CHLA researchers highlight need to include overweight subjects in metabolic research

Children's Hospital Los Angeles investigators have demonstrated the need to include a growing constituency of obese and overweight children and adults in clinical research, with their study of a key marker for metabolism and body temperature control.

23 Aug 2018

Study suggests new possibilities for treating metabolic syndrome

New research, in mice, indicates that a natural sugar called trehalose blocks glucose from the liver and activates a gene that boosts insulin sensitivity, reducing the chance of developing diabetes. Activating the gene also triggers an increase in calories burned, reduces fat accumulation and weight gain, and lessens measures of fats and cholesterol in the blood.

23 Aug 2018

Study finds new way to target escalating rates of obesity

A novel drug is being touted as a major step forward in the battle against Australia’s escalating rates of obesity and associated metabolic diseases.

23 Aug 2018

Eisai: EC approves marketing of LENVIMA as first-line treatment for hepatocellular carcinoma

Eisai Co., Ltd. and Merck & Co., Inc., Kenilworth N.J., U.S.A., known as MSD outside of the United States and Canada, announced today that the European Commission has granted a marketing authorization for the oral receptor tyrosine kinase inhibitor LENVIMA (lenvatinib mesylate) as a single agent for the first-line treatment of adult patients with advanced or unresectable hepatocellular carcinoma who have received no prior systemic therapy.

23 Aug 2018

Immunotherapy combination shrinks melanoma that has spread to the brain

Combination immunotherapy shrank melanoma that has spread to the brain in more than half of the patients in a clinical trial reported in the New England Journal of Medicine led by an investigator at The University of Texas MD Anderson Cancer Center.

23 Aug 2018

Researchers engineer peptide nanoparticles to outsmart biological system and target kidney cells

Remember the scene in the movie Mission: Impossible when Tom Cruise has to sneak into the vault? He had to do all sorts of moves to avoid detection. That's what it's like to sneak a targeted drug into a kidney and keep it from getting eliminated from the body.

22 Aug 2018

New minimally invasive therapy shows promise for long-term reversal of Type 1 diabetes

What if instead of daily insulin injections or wearing pumps, just getting a shot every few months could reverse Type 1 diabetes for you - or your dog?

21 Aug 2018

Promising data supports development of AAVhu37-based gene therapy for hemophilia A

Gene therapy using an optimized adeno-associated virus to deliver the human factor VIII gene to cynomolgus macaques showed a substantial increase in hFVIII expression and no detectable antibody response for 30 weeks in some animals.

21 Aug 2018

Measles cases on the rise in Europe

According to the World Health Organization (WHO), there is a sharp rise in the number of measles cases across Europe in the first six months of this year. Measles has affected over 41,000 individuals and killed 37, says the WHO.

20 Aug 2018

Cocktail of nanoparticles and contaminants may have harmful effects on human cells

Researchers warn that a combination of nanoparticles and contaminants may form a cocktail that is harmful to our cells. In their study, 72 pct. of cells died after exposure to a cocktail of nano-silver and cadmium ions.

20 Aug 2018

Areas with high density of alcohol outlets have more hospital admission rates

Areas with a high density of alcohol outlets have higher drink-related hospital admission rates, a new study from the University of Sheffield has found.

20 Aug 2018

Researchers discuss techniques to help combat growing epidemic of obesity

More than 60 percent of American adults weigh more than is healthy, which results in increased health issues for the patient and high health care costs.

17 Aug 2018

OHSU professor conducts clinical trial with artificial pancreas using Xeris' liquid glucagon

Xeris Pharmaceuticals, Inc., a specialty pharmaceutical company leveraging its novel technology platforms to develop and commercialize ready-to-use injectable and infusible drug formulations, announced today that Jessica Castle, M.D., an associate professor of medicine in the OHSU School of Medicine and OHSU Harold Schnitzer Diabetes Health Center in Portland, Oregon, is conducting a clinical trial with a dual-hormone artificial pancreas using Xeris' ready-to-use liquid glucagon to evaluate a new closed-loop algorithm.

17 Aug 2018

Liver News and Research

Restricting consumption of high-sucrose diet to active part of day avoids adverse effects in rats

Newly discovered target may prevent progression of liver injury to cancer

Very high levels of good cholesterol may increase risk of heart attack and death

Surgeons test new device that keeps the liver warm and circulates blood during transport

Genetic interindividual variability influences nutritional requirements

Fresh and raw diets may provide benefits for dogs, study finds

Alcohol in any amount harmful finds study

CHLA researchers highlight need to include overweight subjects in metabolic research

Study suggests new possibilities for treating metabolic syndrome

Study finds new way to target escalating rates of obesity

Eisai: EC approves marketing of LENVIMA as first-line treatment for hepatocellular carcinoma

Immunotherapy combination shrinks melanoma that has spread to the brain

Researchers engineer peptide nanoparticles to outsmart biological system and target kidney cells

New minimally invasive therapy shows promise for long-term reversal of Type 1 diabetes

Promising data supports development of AAVhu37-based gene therapy for hemophilia A

Measles cases on the rise in Europe

Cocktail of nanoparticles and contaminants may have harmful effects on human cells

Areas with high density of alcohol outlets have more hospital admission rates

Researchers discuss techniques to help combat growing epidemic of obesity

OHSU professor conducts clinical trial with artificial pancreas using Xeris' liquid glucagon

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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