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ARNI therapy trial misses target in heart failure, may have selective benefit only

Heart failure with preserved ejection fraction (HFpEF) is a common condition, affecting millions of people and resulting in significant illness and death. No effective treatments have been developed for this condition.

2 Sep 2019

DNA methylation closely linked to telomere length

Aging is associated with multiple disease conditions. Recently it has been found that many of these illnesses are linked to the length of the telomeres at the ends of every chromosome. Telomere length (TL) is affected by both genetic and epigenetic contributions.

2 Sep 2019

ESC guidelines highlight detrimental impact of pollution, noise on patients with chronic coronary syndromes

The detrimental impact of pollution and noise on patients with chronic coronary syndromes is highlighted for the first time in European Society of Cardiology (ESC) Guidelines published online today in European Heart Journal, and on the ESC website.

31 Aug 2019

New drug shows promise to improve effects of psychological treatment for PTSD

A medication that boosts the body's own cannabis-like substances, endocannabinoids, shows promise to help the brain un-learn fear memories when these are no longer meaningful.

29 Aug 2019

Inflammation in the lungs triggers silent mutation to cause pulmonary hypertension

Researchers at the Stanford University School of Medicine have found that inflammation in the lungs of rats, triggered by something as simple as the flu, may wake up a silent genetic defect that causes sudden onset cases of pulmonary hypertension, a deadly form of high blood pressure in the lungs.

29 Aug 2019

Potential drug could revolutionize the treatment of neurological conditions

The international team of scientists from Gero Discovery LLC, the Institute of Biomedical Research of Salamanca, and Nanosyn, Inc. has found a potential drug that may prevent neuronal death through glucose metabolism modification in stressed neurons.

28 Aug 2019

New study helps explain why lung tumors turn aggressive

Lung cancer is the number 1 killer among cancers, especially when it is of the non-small cell type. Among these, adenocarcinomas are the most common and aggressive type. These tumors also show a strong tendency to show dedifferentiation, or loss of the features that characterize a mature lung cell.

28 Aug 2019

Researchers find a weak spot in cancer cells

Cancer cells form tumors. This statement, simple as it seems, hides a complex failure of normal immune responses that should eliminate tumor cells from the body before they ever form viable cancer masses.

28 Aug 2019

Promising vaccine may protect against the Klebsiella superbug

A powerful superbug, a hypervirulent form of the bacteria Klebsiella pneumoniae, is a very difficult to curb infection. It causes a variety of infections including rare but life-threatening liver, respiratory tract, bloodstream and other infections.

28 Aug 2019

Promising new strategy to treat severe dengue disease on the horizon

Researchers led by Duke-NUS Medical School have discovered that tryptase, an enzyme in human cells that acts like scissors to cut up nearby proteins, is responsible for blood vessel leakage in severe dengue hemorrhagic fever.

27 Aug 2019

Study shows microRNA can protect the heart from reperfusion injury

Heart muscle can continue to die even after restoring blood following a heart attack, and scientists have new evidence that one way to help it live is by boosting levels of a tiny RNA that helped the heart form.

27 Aug 2019

"Australian" genetic mutation provides clues to Alzheimer’s mechanism

In an astonishing new breakthrough in Alzheimer’s research, the molecular basis of early-onset Alzheimer’s disease (AD) and age-linked AD has been identified by looking at one type of genetic mutation.

26 Aug 2019

New mechanisms to enable regeneration of injured nerve fibers

Injuries to nerve fibers in the brain, spinal cord, and optic nerves usually result in functional losses as the nerve fibers are unable to regenerate.

23 Aug 2019

Animal-assisted interventions help reduce patient stress in aeromedical staging facilities

They're physically and emotionally wounded – most likely suffering from post-traumatic stress. Members of the United States military who serve abroad often return to the U.S. to treat their injuries and must be transported by aeromedical evacuation between medical facilities.

23 Aug 2019

Harnessing power of CRISPR to control behavior of DNA-responsive materials

The CRISPR-Cas system has become the go-to tool for researchers who study genes in an ever-growing list of organisms, and is being used to develop new gene therapies that potentially can correct a defect at a single nucleotide position of the vast reaches of the genome.

23 Aug 2019

Scientists identify unique way to treat incurable type of children's brain cancer

An international team of researchers led by Yale University, University of Iowa, and the Translational Genomics Research Institute, an affiliate of City of Hope, has discovered a new pathway that may improve success against an incurable type of children's brain cancer.

23 Aug 2019