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Australian study shows combined genomic screening for major hereditary diseases is cost-effective and health-saving

In an Australian study published in EClinicalMedicine, researchers evaluated the impact of a combined genomic screening program for hereditary breast and ovarian cancer, Lynch syndrome, and familial hypercholesterolemia in young adults. The program proved to be cost-effective, reducing healthcare costs and averting numerous health events, while emphasizing the need for further optimization and equitable access within public healthcare systems.

12 Nov 2023

Gene therapy's double-edged sword: Breakthrough treatments face manufacturing and efficacy

Research explores the advancements, challenges, and economic implications of gene therapy for various diseases, including inherited blood disorders, malignancies treated with CAR-T cells, and diseases targeted by in vivo AAV vectors. The review highlights the transformative potential of gene therapies while acknowledging the complexities in manufacturing, safety, efficacy, and long-term durability.

12 Nov 2023

New study sheds light on the genes and nutrients that give MAIT cells their fighting power

Scientists at La Jolla Institute for Immunology (LJI) are investigating a talented type of T cell.

10 Nov 2023

Research redefines rheumatoid arthritis: Over 314,000 cells analyzed for precise treatment strategies

A new paper recently published in Nature, reported the examination of synovial tissue from the joints of nearly 80 people with RA, in combination with RNA sequencing and surface protein analyses.

10 Nov 2023

New research aims to decipher how animals discard half their genes

New research is underway to decipher a fascinating biological puzzle - how some animals can naturally discard more than half of their genetic information during embryonic development.

9 Nov 2023

Tumor-immune interactions predict treatment responses in multiple myeloma

A multicenter study led by researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine shows how interactions between tumor cells and immune components of the microenvironment can impact treatment responses and outcomes in patients newly diagnosed with multiple myeloma who undergo combination treatments that include targeted immunotherapy.

9 Nov 2023

Study compiles the most comprehensive list of genetic variants associated with prostate cancer risk

A globe-spanning scientific team has compiled the most comprehensive list of genetic variants associated with prostate cancer risk - 451 in all - through a whole-genome analysis that ranks as the largest and most diverse investigation into prostate cancer genetics yet.

9 Nov 2023

Study links lower testosterone levels with increased arthritis risk

The relationship between serological testosterone levels and arthritis among United States (US) adults.

9 Nov 2023

Genetic melting pot: Study unveils complex admixture in European ancestry populations

In a recent Nature Communications study, researchers revealed that Europeans and European Americans possess a significant subcontinental genetic admixture, challenging the notion that these populations are homogenous. This finding suggests the need to re-evaluate genetic epidemiology studies that may have overlooked the influence of admixture on disease associations and trait heritability in these groups.

8 Nov 2023

Cannabis use alters DNA methylation, with implications beyond smoking effects

A large-scale meta-analysis in Molecular Psychiatry reveals that lifetime cannabis use is associated with DNA methylation changes in peripheral blood, which could have implications for understanding the long-term health effects of cannabis consumption.

8 Nov 2023

Study finds 4% of Icelanders to carry an actionable genotype associated with shortened lifespan

Scientists at deCODE genetics, a subsidiary of Amgen, have published a study on actionable genotypes detected in the Icelandic population and their association with lifespan.

8 Nov 2023

Study unravels molecular basis of chronic pain transition

Researchers from the Center for Translational Immunology at University Medical Center Utrecht (the Netherlands) have identified that a transient inflammatory pain causes mitochondrial and redox changes in sensory neurons that persist beyond pain resolution.

8 Nov 2023

Scientists unravel the mystery of how cells keep glutathione levels in check

If a delivery person leaves a package on your front step without pinging you, you likely won't know it's there.

8 Nov 2023

UC Riverside scientists slow progression of Huntington's disease in flies and worms

Huntington's disease causes involuntary movements and dementia, has no cure, and is fatal. For the first time, UC Riverside scientists have shown they can slow its progression in flies and worms, opening the door to human treatments.

8 Nov 2023

Genetic variants likely affect sleep quality and quantity in children, study finds

Previous research has identified genetic variants associated with insomnia and sleep duration in adults. Now a study published in the Journal of Child Psychology and Psychiatry has found that these variants also likely affect sleep quality and quantity in children.

8 Nov 2023

Gene expression in nearby healthy tissue may be a better predictor of lung cancer recurrence

Genetic information collected from seemingly healthy tissue near lung tumors may be a better predictor of whether cancer will come back after treatment than analysis of the tumors themselves, according to new research led by NYU Langone Health and its Perlmutter Cancer Center.

8 Nov 2023

Temperature plays crucial role in virus DNA release and infection

Researchers at Lund University, together with colleagues at the NIST Synchrotron Facility in the USA, have mapped on an atomic level what happens in a virus particle when the temperature is raised.

8 Nov 2023

Can adding RNA sequencing to germline genetic testing improve accuracy and clinical sensitivity over time compared to DNA sequencing alone?

Concurrent sequencing of DNA and RNA to detect the predisposition to hereditary cancer.

8 Nov 2023

Pharmacogenomics holds promise for personalized dementia therapies

Pharmacogenomics-based studies in the research for personalized therapeutics for dementia

8 Nov 2023

CAR-T cell therapy could lead to sustained suppression of autoantibodies in treatment-resistant lupus

New research at ACR Convergence 2023, the American College of Rheumatology's annual meeting, demonstrates that CAR-T cell therapy could lead to sustained suppression of autoantibodies in treatment-resistant lupus while maintaining a robust response to vaccines.

7 Nov 2023

Genetic News and Research

Australian study shows combined genomic screening for major hereditary diseases is cost-effective and health-saving

Gene therapy's double-edged sword: Breakthrough treatments face manufacturing and efficacy

New study sheds light on the genes and nutrients that give MAIT cells their fighting power

Research redefines rheumatoid arthritis: Over 314,000 cells analyzed for precise treatment strategies

New research aims to decipher how animals discard half their genes

Tumor-immune interactions predict treatment responses in multiple myeloma

Study compiles the most comprehensive list of genetic variants associated with prostate cancer risk

Study links lower testosterone levels with increased arthritis risk

Genetic melting pot: Study unveils complex admixture in European ancestry populations

Cannabis use alters DNA methylation, with implications beyond smoking effects

Study finds 4% of Icelanders to carry an actionable genotype associated with shortened lifespan

Study unravels molecular basis of chronic pain transition

Scientists unravel the mystery of how cells keep glutathione levels in check

UC Riverside scientists slow progression of Huntington's disease in flies and worms

Genetic variants likely affect sleep quality and quantity in children, study finds

Gene expression in nearby healthy tissue may be a better predictor of lung cancer recurrence

Temperature plays crucial role in virus DNA release and infection

Can adding RNA sequencing to germline genetic testing improve accuracy and clinical sensitivity over time compared to DNA sequencing alone?

Pharmacogenomics holds promise for personalized dementia therapies

CAR-T cell therapy could lead to sustained suppression of autoantibodies in treatment-resistant lupus

Sequencing & Genomics: Elevating Science and Healthcare eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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