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Researchers crack the genetic code of rare form of kidney cancer

The genetic code of a rare form of kidney cancer, called reninoma, has been studied for the first time. In the new paper, published today (25th September) in Nature Communications, researchers at the Wellcome Sanger Institute, Great Ormond Street Hospital and The Royal Free Hospital also revealed a new drug target that could serve as an alternative treatment if surgery is not recommended.

25 Sep 2023

New model paves way to understanding and preventing SUDEP in familial epilepsy

Researchers at the University of Michigan have developed a model for studying one type of familial epilepsy, opening the door to understanding—and eventually targeting—the mechanisms that lead to the disorder and its associated fatalities.

25 Sep 2023

Is BMI the optimal adiposity marker to assess mortality risk?

Researchers evaluated adiposity markers to determine the marker with the most consistent association mortality.

25 Sep 2023

Could CaMKK2 enzyme be the key to treating bipolar disorder?

Researchers explore the role of the CaMKK2 signaling pathway in bipolar disorder, suggesting it as a new treatment target. By targeting this enzyme, scientists aim to develop more effective therapies for bipolar symptoms and metabolic dysfunction.

24 Sep 2023

Could metformin be a game changer for heart health in non-diabetics?

Using Mendelian randomization, researchers found that altering seven metformin targets led to improved blood pressure and BMI in non-diabetic individuals. The study suggests the potential for metformin's role in reducing cardiovascular risks in the general population, although more research is needed.

24 Sep 2023

Genetic link between migraines and breast cancer risk uncovered

Using Mendelian randomization analysis, the study finds a genetic link between migraine susceptibility and increased risk of overall and estrogen receptor-positive breast cancer. However, the findings suggest caution in interpretation, highlighting the need for further research to solidify these associations.

24 Sep 2023

Everyday chemicals linked to increased cancer risk, especially in women

This study identifies links between exposure to chemicals like PFAS, parabens, and phenols and increased cancer risk, particularly among women and across racial groups. The findings spotlight the role of environmental toxins in hormone-related cancers, suggesting new avenues for cancer prevention and mitigation strategies.

24 Sep 2023

Study reveals non-coding genetic variants associated with Alzheimer’s disease functioning in microglia

Scientists studying Alzheimer's disease (AD) have identified thousands of genetic variants in the genome in the development of this progressive neurodegenerative disease.

23 Sep 2023

Rare genetic variants involved in male-pattern hair loss identified

A receding hairline, a total loss of hair from the crown, and ultimately, the classical horseshoe-shaped pattern of baldness: Previous research into male pattern hair loss, also termed androgenetic alopecia, has implicated multiple common genetic variants.

22 Sep 2023

Peptide vaccine targets H3K27M mutation in midline gliomas, shows promise in early trials

Tumor vaccines can help the body fight cancer. These vaccines alert the patient's immune system to proteins that are carrying cancer-typical alterations.

22 Sep 2023

Omics analysis identifies new biomarkers for predicting mortality in patients with pneumonia

Community-acquired pneumonia (CAP) is a major infectious disease worldwide and contributes to high mortality and massive economic burden. Hospital mortality among the severe CAP (SCAP) remains high, ranging from 25% to more than 50%.

22 Sep 2023

Researchers find a promising drug candidate for the treatment of ALS

A research group at the University of Helsinki and its partners have found a promising drug candidate for the treatment of amyotrophic lateral sclerosis (ALS).

22 Sep 2023

Researchers identifiy the genetic background of dilated cardiomyopathy

Researchers have made a significant finding in determining the genetic background of dilated cardiomyopathy in Dobermanns.

22 Sep 2023

Scientists discover novel microglia-associated risk factors for Alzheimer's disease

Scientists studying Alzheimer's disease (AD) have identified thousands of genetic variants in the genome in the development of this progressive neurodegenerative disease.

22 Sep 2023

Using kinase inhibitors in subsets of colorectal cancer patients

A new editorial paper was published in Oncoscience (Volume 10) on June 27, 2023, entitled, "Kinase-targeted therapy in subsets of colorectal cancer."

22 Sep 2023

New science committee to support One Medicine research at Humanimal Trust

Humanimal Trust, the charity founded in 2014 by orthopaedic veterinary surgeon, Professor Noel Fitzpatrick, has announced a new Committee of independent advisors, made up of leading human and animal health professionals, academics and researchers from around the world.

22 Sep 2023

VAX-seq: the future of mRNA vaccine analysis and quality assurance?

Researchers proposed a simplified approach for analyzing mRNA vaccines using long-read sequencing.

22 Sep 2023

Decoding tauopathies: New study identifies non-coding RNA as a key player in Alzheimer's

Researchers at Washington University School of Medicine identify a key step in the development of harmful tau tangles, offering a potential target for preventing brain damage in diseases like Alzheimer's. The study highlights the role of long noncoding RNAs, particularly SNHG8, in stress granule formation and tau aggregation, opening new avenues for treatment.

22 Sep 2023

CPRIT awards $2 million to SMU to recruit cancer biology researcher Annika Wylie

The Cancer Prevention and Research Institute of Texas (CPRIT) has awarded $2 million to recruit Annika Wylie to SMU and fund five years of her research, which focuses on the p53 gene, a naturally occurring tumor suppressor.

21 Sep 2023

Scientists identify mutations in 11 genes associated with aggressive forms of prostate cancer

An international research team led by scientists in the Center for Genetic Epidemiology at the Keck School of Medicine of USC and USC Norris Comprehensive Cancer Center has singled out mutations in 11 genes that are associated with aggressive forms of prostate cancer.

21 Sep 2023