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Regenerative medicine takes leap forward with nasal cartilage-derived cartilage grafts

The Department of Biomedicine at the University of Basel and the University Hospital Basel, today announced that it delivered the first surgical procedure to treat Osteoarthritis (OA) in humans.

15 Nov 2023

Plant-based diets regulate gestational weight gain in early pregnancy

The study in the European Journal of Clinical Nutrition found that Iranian pregnant women adhering to plant-based diets had a lower risk of inadequate gestational weight gain, with no significant association observed between these diets and excessive gestational weight gain.

14 Nov 2023

New approach to CAR T cell therapy may extend treatment effectiveness

CAR T cell therapy, a powerful type of immunotherapy, has begun to revolutionize cancer treatment. Pioneered at Memorial Sloan Kettering Cancer Center (MSK), the therapy involves engineering a patient's T cells so they recognize and attack cancer cells.

14 Nov 2023

Study reveals mechanisms underlying non-suppressible HIV viremia

Human immunodeficiency virus (HIV) works by entering specific immune cells and replicating inside them.

14 Nov 2023

Aspirin avoidance improves clinical outcomes in patients with advanced heart failure

Left ventricular assist devices (LVADs) are pumps that are used to circulate blood in patients with weakened hearts due to advanced heart failure. Mechanical stress on these implants can make patients susceptible to blood clots, and patients are required to take anti-clotting medications including vitamin-k antagonists (VKA) and aspirin.

14 Nov 2023

Gene therapy for rare diseases: A decade of progress and remaining challenges

A new review article in the peer-reviewed journal Human Gene Therapy summarizes the significant milestones in the development of gene therapy medicinal products that have facilitated the treatment of a significant number of rare diseases.

14 Nov 2023

High-dose CBD fails to relieve pain in knee osteoarthritis patients

Cannabidiol (CBD) is marketed by some suppliers as a painkiller, e.g. for osteoarthritis of the knee. Animal experiments have shown that the substance, which is extracted from the hemp plant, has an anti-inflammatory and pain-relieving effect in arthritis.

14 Nov 2023

Cancer stem cells induce macrophage aging, creating conditions for tumor formation

Cancer stem cells cause the aging of macrophages in mice with healthy immune systems, creating conditions for the formation of tumors.

14 Nov 2023

New gel delivery system overcomes challenges of intratumoral cancer immunotherapy

Intratumoral therapy – in which cancer drugs are injected directly into tumors – is a promising treatment option for solid cancers but has shown limited success in clinical trials due to an inability to precisely deliver the drug and because most immunotherapies quickly dissipate from the site of injection.

13 Nov 2023

Acupuncture may offer limited relief from chronic spontaneous urticaria, study finds

A randomized controlled trial that included more than 300 people diagnosed with chronic spontaneous urticaria (CSU), or hives, found that acupuncture may offer limited relief from the condition, but clinical significance of this finding was unclear.

13 Nov 2023

Rat study suggests hemodialysis plus ketogenic diet could enhance cancer treatment

The study in Scientific Reports investigates the potential of hemodialysis (HD) to sustain elevated blood ketone levels in rats on a ketogenic diet, exploring its use as an adjunct in cancer treatment. Results show that HD maintains ketone levels while reducing glucose and insulin, suggesting a possible enhancement in cancer treatment efficacy.

13 Nov 2023

Novel assay may improve detection and treatment of acute myeloid leukemia

A novel assay that detects a unique molecular marker in patients with acute myeloid leukemia (AML) may revolutionize the way this disease is detected and treated according to a new report in The Journal of Molecular Diagnostics published by Elsevier.

13 Nov 2023

Automated referrals to pharmacy services dramatically increase appropriate statin prescription rates

The odds of prescribing the appropriate dose of statins - a medicine used to lower "bad" cholesterol levels - increased sixfold when automated referrals were made to pharmacy services, instead of relying on traditional prescribing methods, according to researchers at the Perelman School of Medicine at the University of Pennsylvania.

13 Nov 2023

One in five individuals taking nirmatrelvir-ritonavir therapy found to experience rebound COVID

A new study by investigators from Mass General Brigham found that one in five individuals taking Nirmatrelvir-ritonavir therapy, commonly known as Paxlovid, to treat severe symptoms of COVID-19, experienced a positive test result and shedding of live and potentially contagious virus following an initial recovery and negative test - a phenomenon known as virologic rebound.

13 Nov 2023

Discovery of two new enzymes offers easier ways to study and manufacture complex natural chemicals

Slumbering among thousands of bacterial strains in a collection of natural specimens at The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, several fragile vials held something unexpected, and possibly very useful.

13 Nov 2023

"Christchurch mutation" can block detrimental effects of Alzheimer’s risk factor

Researchers at Gladstone Institutes have discovered that a rare genetic variant known as the "Christchurch mutation" can block detrimental effects of apolipoprotein E4, the best-established risk factor for the most common form of Alzheimer's disease.

13 Nov 2023

Unlocking the cure for hepatitis B virus: Challenges and opportunities

Hepatitis B virus (HBV) is a significant public health problem, with over 296 million people chronically infected worldwide.

13 Nov 2023

AI-based model can predict therapy outcome in ovarian cancer patients

A model based on artificial intelligence is able to predict the therapy outcome (measured by volumetric reduction of tumor lesions) in 80% of ovarian cancer patients.

13 Nov 2023

Recaticimab injection every 1-3 months may safely lower bad cholesterol

A new PCSK9 inhibitor (recaticimab) injected every one to three months may work safely and provide more flexible dosing to lower cholesterol, according to late-breaking science presented today at the American Heart Association's Scientific Sessions 2023.

13 Nov 2023

New drug zilebesiran effectively lowers blood pressure for six months, study finds

A single injection of the experimental medication zilebesiran was safe and effective in reducing systolic blood pressure in people with mild-to-moderate high blood pressure for up to six months, as detailed in the Phase 2 of the KARDIA study, reported as late-breaking science today at the American Heart Association's Scientific Sessions 2023.

13 Nov 2023

Therapy News and Research

Regenerative medicine takes leap forward with nasal cartilage-derived cartilage grafts

Plant-based diets regulate gestational weight gain in early pregnancy

New approach to CAR T cell therapy may extend treatment effectiveness

Study reveals mechanisms underlying non-suppressible HIV viremia

Aspirin avoidance improves clinical outcomes in patients with advanced heart failure

Gene therapy for rare diseases: A decade of progress and remaining challenges

High-dose CBD fails to relieve pain in knee osteoarthritis patients

Cancer stem cells induce macrophage aging, creating conditions for tumor formation

New gel delivery system overcomes challenges of intratumoral cancer immunotherapy

Acupuncture may offer limited relief from chronic spontaneous urticaria, study finds

Rat study suggests hemodialysis plus ketogenic diet could enhance cancer treatment

Novel assay may improve detection and treatment of acute myeloid leukemia

Automated referrals to pharmacy services dramatically increase appropriate statin prescription rates

One in five individuals taking nirmatrelvir-ritonavir therapy found to experience rebound COVID

Discovery of two new enzymes offers easier ways to study and manufacture complex natural chemicals

"Christchurch mutation" can block detrimental effects of Alzheimer’s risk factor

Unlocking the cure for hepatitis B virus: Challenges and opportunities

AI-based model can predict therapy outcome in ovarian cancer patients

Recaticimab injection every 1-3 months may safely lower bad cholesterol

New drug zilebesiran effectively lowers blood pressure for six months, study finds

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