Fluorescent Protein News and Research

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Alpha cells in pancreas can convert into insulin-producing beta cells: Study

Alpha cells in the pancreas, which do not produce insulin, can convert into insulin-producing beta cells, advancing the prospect of regenerating beta cells as a cure for type 1 diabetes. The findings come from a study at the University of Geneva, co-funded by the Juvenile Diabetes Research Foundation, that is published today in the online edition of the scientific journal Nature.

6 Apr 2010

'Doublesex' gene also sculpts brain and nervous system architecture leading to sex-specific behaviours

The brains of males and females, and how they use them, may be far more different then previously thought, at least in the fruit fly Drosophila melanogaster, according to research funded by the Wellcome Trust.

22 Mar 2010

Reversing protein deficiency through gene therapy can improve SMA

Reversing a protein deficiency through gene therapy can correct motor function, restore nerve signals and improve survival in mice that serve as a model for the lethal childhood disorder spinal muscular atrophy, new research shows.

1 Mar 2010

Retinitis Pigmentosa: Embryonic stem cells for replacement of diseased retinal cells and restoration of sight

An international research team led by Columbia University Medical Center successfully used mouse embryonic stem cells to replace diseased retinal cells and restore sight in a mouse model of retinitis pigmentosa. This strategy could potentially become a new treatment for retinitis pigmentosa, a leading cause of blindness that affects approximately one in 3,000 to 4,000 people, or 1.5 million people worldwide.

25 Feb 2010

Researchers measure diffusion coefficient of a protein in a primary cilium

A team of researchers led by Peter Calvert (SUNY Upstate Medical University) has, for the first time, measured the diffusion coefficient of a protein in a primary cilium and in other major compartments of a highly polarized cell. The study appears in the March issue of the Journal of General Physiology.

22 Feb 2010

Neuroimaging study may lead to new therapeutic treatments for stroke and hearing loss

Duke University Medical Center scientists crowded around a laser-powered microscope in a darkened room to peer into the brain of an anesthetized juvenile songbird right after he heard an adult tutors' song for the first time.

18 Feb 2010

New fluorescent probes improve tumor detection in mice

Building on his Nobel Prize-winning work creating fluorescent proteins that light up the inner workings of cells, a team of researchers led by Howard Hughes Medical Institute investigator Roger Tsien, PhD, professor of pharmacology, chemistry and biochemistry at the University of California, San Diego and the Moores UCSD Cancer Center has developed biological probes that can stick to and light up tumors in mice.

17 Feb 2010

Stanford researchers use DNA minicircles to induce pluripotency in stem cells from human fat

Tiny circles of DNA are the key to a new and easier way to transform stem cells from human fat into induced pluripotent stem cells for use in regenerative medicine, say scientists at the Stanford University School of Medicine. Unlike other commonly used techniques, the method, which is based on standard molecular biology practices, does not use viruses to introduce genes into the cells or permanently alter a cell's genome.

8 Feb 2010

Study lays groundwork to develop new treatments for cardiovascular disease and other conditions

In a significant step toward restoring healthy blood circulation to treat a variety of diseases, a team of scientists at Weill Cornell Medical College has developed a new technique and described a novel mechanism for turning human embryonic and pluripotent stem cells into plentiful, functional endothelial cells, which are critical to the formation of blood vessels.

21 Jan 2010

Quorum sensing offers a dynamic approach to increase sensitivity to external signals

Researchers at UC San Diego who last year genetically engineered bacteria to keep track of time by turning on and off fluorescent proteins within their cells have taken another step toward the construction of a programmable genetic sensor. The scientists recently synchronized these bacterial "genetic clocks" to blink in unison and engineered the bacterial genes to alter their blinking rates when environmental conditions change.

21 Jan 2010

Stem cell therapy holds promise as potential alternative to bone grafting operations

A study published this week reinforces the potential value of stem cells in repairing major injuries involving the loss of bone structure.

12 Jan 2010

New therapeutic treatment may provide a potential alternative to bone grafting operation

A study published this week reinforces the potential value of stem cells in repairing major injuries involving the loss of bone structure.

12 Jan 2010

Gene therapy may help correct molecular flaws that cause brain disease

Neuroscientists have forged an unlikely molecular union as part of their fight against diseases of the brain and nervous system.

9 Jan 2010

Cell transplants may yield new therapies for dementia patients

Nerve cells transplanted into brain-damaged rats helped them to fully recover their ability to learn and remember, probably by promoting nurturing, protective growth factors, according to a new study.

10 Dec 2009

Dermal stem cells may be useful for treating diabetic ulcers and neurological disorders

Scientists have discovered a new type of stem cell in the skin that acts surprisingly like certain stem cells found in embryos: both can generate fat, bone, cartilage, and even nerve cells.

10 Dec 2009

Scientists identify potential drug development target for epilepsy seizures

A team of scientists from The University of Alabama used worms to reel in information that they hope will lead to a greater understanding of cellular mechanisms that may be exploited to treat epilepsy.

10 Dec 2009

CompuCyte expands iGeneration line of imaging cytometers to include four-laser versions

CompuCyte Corporation, the pioneer in the field of imaging cytometry instrumentation and the leading supplier of laser scanning cytometers, announced that it has expanded its state-of-the art iGeneration line of imaging cytometers to include four-laser versions of the iCyte®, iCys® and iColor® systems.

8 Dec 2009

Study suggests brain can integrate new information without jeopardizing established memories

Our ability to learn new information and adapt to changes in our daily environment, as well as to retain lifelong memories, appears to lie in the minute junctions where nerve cells communicate, according to a new study by NYU Langone Medicine Center researchers. The study is published online this week in the journal Nature.

4 Dec 2009

Comprehensive investigation employing FRET to study amino acid transporter GAT1 reported

In the December 2009 issue of the Journal of General Physiology (www.jgp.org), Moss et al. report a comprehensive investigation employing F-rster resonance energy transfer (FRET) to study the {gamma}-amino acid (GABA) transporter GAT1, a member of the family that includes transporters for neurotransmitters dopamine (DAT), serotonin (SERT), norepinephrine (NET) and glycine (GlyT).

1 Dec 2009

Study explores brain's rewiring processes during motor learning

New connections begin to form between brain cells almost immediately as animals learn a new task, according to a study published this week in Nature. Led by researchers at the University of California, Santa Cruz, the study involved detailed observations of the rewiring processes that take place in the brain during motor learning.

30 Nov 2009

Fluorescent Protein News and Research

Alpha cells in pancreas can convert into insulin-producing beta cells: Study

'Doublesex' gene also sculpts brain and nervous system architecture leading to sex-specific behaviours

Reversing protein deficiency through gene therapy can improve SMA

Retinitis Pigmentosa: Embryonic stem cells for replacement of diseased retinal cells and restoration of sight

Researchers measure diffusion coefficient of a protein in a primary cilium

Neuroimaging study may lead to new therapeutic treatments for stroke and hearing loss

New fluorescent probes improve tumor detection in mice

Stanford researchers use DNA minicircles to induce pluripotency in stem cells from human fat

Study lays groundwork to develop new treatments for cardiovascular disease and other conditions

Quorum sensing offers a dynamic approach to increase sensitivity to external signals

Stem cell therapy holds promise as potential alternative to bone grafting operations

New therapeutic treatment may provide a potential alternative to bone grafting operation

Gene therapy may help correct molecular flaws that cause brain disease

Cell transplants may yield new therapies for dementia patients

Dermal stem cells may be useful for treating diabetic ulcers and neurological disorders

Scientists identify potential drug development target for epilepsy seizures

CompuCyte expands iGeneration line of imaging cytometers to include four-laser versions

Study suggests brain can integrate new information without jeopardizing established memories

Comprehensive investigation employing FRET to study amino acid transporter GAT1 reported

Study explores brain's rewiring processes during motor learning

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