Immunosuppression News and Research

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Immunosuppression involves an act that reduces the activation or efficacy of the immune system. Some portions of the immune system itself have immuno-suppressive effects on other parts of the immune system, and immunosuppression may occur as an adverse reaction to treatment of other conditions.

Moderation and appropriate rest periods may be key to healthier CrossFit workouts

Are you a fitness enthusiast? If so, moderation and appropriate rest periods may be the key to healthier exercise, as consecutive CrossFit-style workouts could impair the immune system by affecting inflammatory proteins.

1 Sep 2016

Scientists generate functional tissue-engineered liver from adult stem and progenitor cells

A research team led by investigators at The Saban Research Institute of Children's Hospital Los Angeles has generated functional human and mouse tissue-engineered liver from adult stem and progenitor cells.

31 Aug 2016

Research findings pave way to effective strategies for treatment of visceral leishmaniasis

A study shows that stimulating the production of interleukin-17A (IL-17A), one of the cytokines released by cells of the immune system, can be an effective strategy for the treatment of visceral leishmaniasis, considered one of the six most important parasitic diseases affecting humans.

25 Aug 2016

ECTRIMS previews important sessions ahead of world’s largest annual congress of multiple sclerosis

The European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) previews the key sessions ahead of its annual congress – a dedicated platform to promote and enhance research in Multiple Sclerosis. The 32nd edition of the world’s largest congress of multiple sclerosis will take place in London from 14 – 17 September 2016.

17 Aug 2016

Coordinated treatment for both illnesses could save lives of people with HIV and TB

Tuberculosis (TB) is a leading killer of people with HIV, and providing therapy for both illnesses simultaneously saves lives - according to new guidelines on the treatment of drug-susceptible TB developed jointly by the American Thoracic Society, Centers for Disease Control and Prevention and Infectious Diseases Society of America.

11 Aug 2016

Umbilical CBT more effective than MUD bone marrow transplants for leukemia patients

A University of Colorado Cancer Center study compared outcomes of leukemia patients receiving bone marrow transplants from 2009-2014, finding that three years post transplant, the incidence of severe chronic graft-versus-host disease was 44 percent in patients who had received transplants from matched, unrelated donors (MUD) and 8 percent in patients who had received umbilical cord blood transplants (CBT).

27 Jul 2016

New, minimally invasive procedure may be effective for patients with FED

A new, minimally invasive procedure appears to be effective for many patients with Fuchs endothelial dystrophy (FED), a common eye disease, without the potential side effects and cost of the current standard of care, a cornea transplant.

13 Jul 2016

Chromatrap reports benefits of ChIP technology in ground breaking research

Chromatrap reports on 3 further customer papers published in different prestigious peer reviewed journals, which cite how its proprietary solid state Chromatin Immunoprecipitation (ChIP) technology has enabled ground breaking research.

From Chromatrap® - Porvair Sciences Ltd 12 Jul 2016

Immunotherapy in conjunction with drugs could be effective in treating pancreatic cancer

While immune therapy has proven effective in treating certain types of cancer, especially lung cancer and melanoma, tumors of the pancreas remain among the most difficult to treat and, so far, are impervious to immune-based therapies.

4 Jul 2016

New strategy treats fatal autoimmune disease without outward off-target effects

In a study with potentially major implications for the future treatment of autoimmunity and related conditions, scientists from the Perelman School of Medicine at the University of Pennsylvania have found a way to remove the subset of antibody-making cells that cause an autoimmune disease, without harming the rest of the immune system.

4 Jul 2016

Study opens up new strategy to make immunotherapy more effective for different cancer types

By combining local radiation therapy and anti-cancer vaccines with checkpoint inhibitors, researchers from the University of Chicago, working with mice, were able to increase the response rate for these new immunotherapy agents.

14 Jun 2016

Combining VCA with organ transplants improves patient outcomes

Simultaneous transplantation of a "composite" skull and scalp flap plus a kidney and pancreas—all from the same donor—provided excellent outcomes for a patient with a non-healing scalp defect and declining organ kidney and pancreas function, according to a report in the June issue of Plastic and Reconstructive Surgery, the official medical journal of the American Society of Plastic Surgeons.

28 May 2016

Nanoparticle-based gene therapy may hold promise for patients with asthma

A new study has demonstrated a way to deliver a nanoparticle-based gene therapy, in order to repair lungs damaged by chronic allergic asthma and to reduce inflammation that causes asthma attacks.

19 May 2016

Oral administration of Jakinibs reduces Parkinson's disease pathogenesis in rat model

University of Alabama at Birmingham researchers report the first documentation that suppressing a key cell-signaling pathway in a rat model of Parkinson's disease reduces pathogenesis. Oral administration of AZD1480 — one of the JAK/STAT pathway inhibitors generally known as Jakinibs — lessened the destructive inflammation and nerve cell degradation in the area of the brain affected by Parkinson's.

4 May 2016

Transplanted human islets provide excellent glycemic control for Type 1 diabetes patients with severe hypoglycemia

Northwestern Medicine researchers are co-investigators in a breakthrough clinical trial that found transplanted human islets prevent hypoglycemic events and provide excellent glycemic control for patients with Type 1 diabetes with severe hypoglycemia. The results of the multi-center, single arm, phase III study are published in Diabetes Care on Monday, April 18. The research was funded by National Institute of Health grants through the National Institute of Allergy and Infectious Diseases and the National Institute for Diabetes and Digestive and Kidney Disease.

3 May 2016

Study shows beneficial effect of hNSC transplantation for TBI

Traumatic brain injury (TBI) is a major cause of mortality and morbidity, often causing lifelong disability for those who survive. Treatment is limited to supportive care, but stem cell therapy has received recent attention as a way to promote recovery for injuries to the central nervous system (CNS). In this study, researchers transplanted human neural stem cells (hNSCs) into the brains of mice modeled with TBI to investigate whether the hosts' immune systems and the stem cells acting in concert would enhance repair.

20 Apr 2016

Transplanted human islets prevent hypoglycemic events in Type 1 diabetes patients

19 Apr 2016

Genetically modified pig hearts can survive for more than 2 years after transplantation into baboons

Could organs explanted from other mammals save human lives someday? A new study shows that genetically modified pig hearts developed by US and Ludwig-Maximilians-Universitaet in Munich researchers can survive for more than up to 2½ years when transplanted into baboons.

7 Apr 2016

Phenotypic personalized medicine can identify a person's optimal drug, dose combinations

For decades, doctors and scientists have predicted that personalized medicine — tailoring drug doses and combinations to people's specific diseases and body chemistry — would be the future of health care.

7 Apr 2016

Autologous haematopoietic stem cell transplantation promise for myasthenia gravis

Study findings in seven patients with severe myasthenia gravis support the use of autologous haematopoietic stem cell transplantation for achieving long-term remission.

7 Apr 2016

Immunosuppression News and Research

Further Reading

Moderation and appropriate rest periods may be key to healthier CrossFit workouts

Scientists generate functional tissue-engineered liver from adult stem and progenitor cells

Research findings pave way to effective strategies for treatment of visceral leishmaniasis

ECTRIMS previews important sessions ahead of world’s largest annual congress of multiple sclerosis

Coordinated treatment for both illnesses could save lives of people with HIV and TB

Umbilical CBT more effective than MUD bone marrow transplants for leukemia patients

New, minimally invasive procedure may be effective for patients with FED

Chromatrap reports benefits of ChIP technology in ground breaking research

Immunotherapy in conjunction with drugs could be effective in treating pancreatic cancer

New strategy treats fatal autoimmune disease without outward off-target effects

Study opens up new strategy to make immunotherapy more effective for different cancer types

Combining VCA with organ transplants improves patient outcomes

Nanoparticle-based gene therapy may hold promise for patients with asthma

Oral administration of Jakinibs reduces Parkinson's disease pathogenesis in rat model

Transplanted human islets provide excellent glycemic control for Type 1 diabetes patients with severe hypoglycemia

Study shows beneficial effect of hNSC transplantation for TBI

Transplanted human islets prevent hypoglycemic events in Type 1 diabetes patients

Genetically modified pig hearts can survive for more than 2 years after transplantation into baboons

Phenotypic personalized medicine can identify a person's optimal drug, dose combinations

Autologous haematopoietic stem cell transplantation promise for myasthenia gravis

Event guide: 4th Extra-Hepatic Lipid-Based Nanoparticles Delivery Summit eBook

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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