Leptin News and Research

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Leptin is a 16 kDa protein hormone that plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism. It is one of the most important adipose derived hormones. The ''Ob(Lep)'' gene (Ob for obese, Lep for leptin) is located on chromosome 7 in humans.

Molecular link between high fat diets and type 2 diabetes established

Howard Hughes Medical Institute researchers have discovered a molecular link between a high-fat, Western-style diet, and the onset of type 2 diabetes. In studies in mice, the scientists showed that a high-fat diet disrupts insulin production, resulting in the classic signs of type 2 diabetes.

29 Dec 2005

Insight into how marajuana induced munchies works

Marijuana--or more specifically its active ingredient, tetrahydrocannabinol--has a well-documented tendency to stimulate hunger. And while scientists have traced this property to cannabinoid receptors in the brain, they have had little understanding of the neural circuitry underlying this effect.

22 Dec 2005

Aquaporin related to obesity

Dr. Gema Fruhbeck, director of the Metabolic Research Laboratory of the University Hospital of the University of Navarra, has published a commentary in the latest issue of Nature. The article presents aquaporin as a new modulator of the biology of the adipocyte.

21 Dec 2005

Understanding obesity in humans

A new study by researchers at UT Southwestern Medical Center suggests that when fat cells increase in size - as they do during the development of obesity - the cells progressively lose receptors for the hormone leptin, a powerful stimulus for fat burning.

7 Dec 2005

Fighting the flab? it could be that hormone!

Fighting the flab? well take heart it could all be down to your hormones - or it seems down to one in particular.

5 Dec 2005

Why we put weight back on

You've successfully dropped those extra pounds only to discover that they creep back on again. Columbia University researchers may have now worked out why.

2 Dec 2005

Newly discovered hormone obestatin could help fight obesity

They hope that the hormone, obestatin, which belongs to the same family ghrelin, which stimulates the appetite, may be a key to the fight against obesity.

13 Nov 2005

New discovery helps explain complex neurocircuitry behind body weight control

A study led by a scientific team at Beth Israel Deaconess Medical Center (BIDMC) provides another important step in our understanding of the critical role that the brain's molecular pathways play in the development of obesity and related disorders.

7 Nov 2005

Scientists unravel complex mechanisms in the brain that regulate body weight

Scientists are one step closer to unraveling the complex mechanisms in the brain that regulate body weight. Working with mice -- whose appetites are controlled by systems very similar to those in humans – they have identified a specific type of neuron that is essential for feeding behavior.

30 Oct 2005

To improve the diets of British children we need to look beyond school dinners

The health of pupils eating school dinners is no worse - and in some respects may be better - than that of pupils eating meals provided from home, concludes a study published online by the British Medical Journal today.

5 Oct 2005

Study shows that high-fat diets correlate to a chronic inflammatory state in the liver,

Mice that were fed diets high in fat and sugar developed immune system abnormalities in their livers, including reduced numbers of natural killer T (NKT) cells. These diet-related changes may contribute to obesity-related liver disease, according to a new study.

3 Oct 2005

SH2-B enhances brain's leptin sensitivity - may lead to clues for treatment of obesity and diabetes

What do laboratory mice at the University of Michigan Medical School have in common with millions of overweight Americans? Like many of us, these mice just can't stop eating.

18 Aug 2005

Weight control protein may yield new approaches for treating obesity and type 2 diabetes

The findings in mice further suggest that particular variants of the protein SH2-B might underlie obesity in humans, the researchers said.

16 Aug 2005

Fructose sweetning could be even worse than using other sweeteners

A University of Cincinnati (UC) study provides new evidence that drinking large amounts of beverages containing fructose adds body fat, and might explain why sweetening with fructose could be even worse than using other sweeteners.

31 Jul 2005

New treatment that boosts the stomach's 'full' signal offers new way of tackling growing obesity epidemic

A hormone found in the small intestine has provided a crucial breakthrough in developing new drugs to tackle the growing obesity epidemic, claim scientists. Obesity now affects more than half of all UK adults, costing the UK up to 3.7 billion pounds a year in sickness absence and treatments.

25 Jul 2005

Protein found in fat cells is a newly discovered cause of insulin resistance

A study led by researchers at Beth Israel Deaconess Medical Center (BIDMC) has shown that a protein found in fat cells is a newly discovered cause of insulin resistance, establishing a previously unidentified molecular link between obesity and type 2 diabetes and offering a potential new target for the development of drugs to treat diabetes.

20 Jul 2005

Research into a protein for treatment of cancer brings prestigious award

Although primarily known for its roles in obesity and reproduction, the protein leptin has been linked to breast cancer in a study which is the recipient of the prestigious Susan G. Komen Foundation award.

28 Jun 2005

People who smoke or are obese are biologically older than slim individuals and non-smokers

Obesity and smoking are important risk factors for many age-related diseases. Tim Spector (St. Thomas’ Hospital, UK) and colleagues in the USA looked for evidence of ageing at a molecular level in smokers and obese individuals.

13 Jun 2005

Poor diet during pregnancy increases risk of child being obese

It is common knowledge that a well balanced diet in pregnancy is crucial, but now scientists say they believe a poor diet during pregnancy appears to raise the chances of having an obese child.

12 Jun 2005

Unique therapeutic strategy to combat cachexia

Researchers at Oregon Health & Science University's Doernbecher Children's Hospital have uncovered a unique therapeutic strategy to combat cachexia - severe malnutrition and physical wasting away - in children and adults with chronic kidney disease (CKD). The study is published in the June issue of the Journal of Clinical Investigation.

9 Jun 2005