Receptor News and Research

RSS

Alzheimer’s plaques decline after CAR-T immune cell treatment in preclinical study

Researchers engineered CD4+ chimeric antigen receptor T cells targeting fibrillar amyloid beta and tested them in a mouse Alzheimer model. The preclinical study showed reduced amyloid pathology and altered neuroimmune responses, supporting CAR-T immunotherapy as a potential future Alzheimer strategy.

11 Feb 2026

Sustained high progesterone during pregnancy can improve menstrual cyclicity in PCOS patients

Polycystic ovary syndrome (PCOS) affects 6%−20% of reproductive-aged women, and is commonly accompanied by irregular menstrual cycles and anovulatory infertility.

11 Feb 2026

Semaglutide lowers cardiovascular events even without major weight loss, researchers report

Semaglutide reduced major adverse cardiovascular events in adults with overweight or obesity and established cardiovascular disease regardless of baseline adiposity. Cardiovascular benefit was largely independent of overall weight loss, with waist circumference reduction explaining only part of the effect.

11 Feb 2026

Transcription factor HOXD13 drives melanoma growth and immune evasion

A molecule that helps regulate gene activity has also been shown to drive skin cancer growth and tumors' ability to evade attack by the body's immune system, a new study shows.

11 Feb 2026

Review links betel nut addiction to cancer, heart disease, and metabolic risks

This review examines the epidemiology, health risks, neurobiological mechanisms, and emerging treatments related to betel nut addiction worldwide. It highlights strong links with oral cancer, cardiometabolic disease, and addiction pathways while noting limited established therapies and the need for coordinated public health strategies.

11 Feb 2026

Study identifies neural mechanism underlying chills during infection

When running a fever during infection, we often feel chills, which prompt us to take action to warm ourselves, such as turning on a heater or adding layers of clothing.

10 Feb 2026

Engineered CAR-T cells reduce Alzheimer’s plaques in mice

Chimeric antigen receptor (CAR) T cell therapy, a type of immunotherapy that leverages the immune system to combat diseases, is a powerful treatment option for certain cancers.

9 Feb 2026

Tirzepatide shows dual benefits in sleep apnea trial improving metabolism and reducing inflammation

Tirzepatide significantly improved cardiometabolic risk markers in adults with obesity and moderate to severe obstructive sleep apnea in the SURMOUNT-OSA phase 3 trials. Mediation analyses suggest both weight loss and reduced sleep-disordered breathing contributed to improvements in inflammation, insulin resistance, lipids, and blood pressure.

9 Feb 2026

Historical redlining's impact on breast cancer survival changes over time

Historical redlining, a 1930s–1960s residential segregation policy, has been linked to shorter survival time in people with breast cancer.

9 Feb 2026

Chronic alcohol use profoundly alters gene expression in the brain's reward system

Chronic alcohol consumption profoundly alters gene expression in key brain regions involved in reward, impulse control, and decision-making, according to a study led by researchers at the Institute for Neurosciences, a joint center of Miguel Hernández University of Elche (UMH) and the Spanish National Research Council (CSIC).

9 Feb 2026

Burn pit particles trigger lung inflammation through immune activation

A new study from National Jewish Health helps explain how exposure to burn pit smoke and desert dust may damage the lungs of military service members deployed to regions such as Afghanistan and Iraq.

7 Feb 2026

Single-cell study uncovers cardiomyocyte-fibroblast signaling in ischemia-reperfusion injury

Announcing a new article publication for BIO Integration journal. Cardiac cell death and myocardial fibrosis after ischemia-reperfusion (I/R) injury are the primary causes of impaired cardiac function.

6 Feb 2026

Senescent neutrophils promote tumor survival across cancer types

Renowned as first responders to threatening infections, neutrophils also happen to feature prominently in the microenvironment of tumors, where they and other immune cells play opposing and frequently mutable roles in promoting-or resisting-cancer progression.

6 Feb 2026

Maternal perinatal depression linked to autistic traits in toddlers

A research team from the Department of Psychiatry at Tohoku University, led by Dr. Zhiqian Yu and Professor Hiroaki Tomita, has uncovered compelling evidence that maternal perinatal depression - psychological distress occurring during pregnancy or postpartum - elevates the risk of autistic-related traits in toddlers, with a particularly strong impact on girls.

5 Feb 2026

Study identifies genetic fingerprint of neuropathic pain neurons

Researchers from The University of Texas at Dallas and their international colleagues have determined the molecular signature of human sleeping - or silent - nociceptors: sensory neurons that are unresponsive to touch or pressure yet are key culprits in neuropathic pain.

4 Feb 2026

Molecular signature of sleeping nociceptors offers new pain targets

Researchers from the Centre for Addiction and Mental Health (CAMH) and the Institute of Neurophysiology at Uniklinik RWTH Aachen in Germany have deciphered the molecular signature of so-called sleeping nociceptors-a type of pain-sensing nerve cell that normally remains quiet and does not respond to touch or pressure, but can become overactive and drive chronic pain.

4 Feb 2026