Signaling Pathway News and Research

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Researchers discover cell signaling pathway responsible for the development of esophageal cancers

Of the roughly 20,000 people in the U.S. diagnosed with esophageal cancer this year, just 4,000 are likely to still be alive in 2027.

28 Jul 2022

Hollings researcher awarded grant to continue research into mechanisms behind medulloblastoma relapse

When MUSC Hollings Cancer Center researcher Jezabel R. Blanco, Ph.D., began studying neurosciences, first as a graduate student and later as a postdoctoral fellow, her research was focused on understanding the mechanisms underlying brain disease, both in the context of neurodegeneration and cancer, but mostly from a basic research angle.

20 Jul 2022

Discovery about how a certain protein is activated in tumor cells could lead to better treatments

Better treatments for some of cancer's deadliest forms could be closer due to a University of California, Irvine-led discovery about how a certain protein is activated in tumor cells.

19 Jul 2022

Exploring the connection between Parkinson's disease and gut microbiota to uncover potential therapeutic targets

Scientists have published a new review focusing on the relationship between PD and gut microbiota.

15 Jul 2022

Study reveals a new molecular perspective to the cause of Gaucher's disease

A study by researchers at Baylor College of Medicine, the Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital and collaborating institutions is the first to associate neuronal activity to the levels of sphingolipids, a type of fat, in brain cells.

13 Jul 2022

Scientists identify molecules promoting plant immunity

Two studies published by researchers at the Max Planck Institute for Plant Breeding Research in Cologne, Germany in collaboration with colleagues in China have discovered natural cellular molecules that drive critical plant immune responses.

7 Jul 2022

COVID-19 impairs the insulin/IGF signaling pathway

Scientists evaluate the impact of SARS-CoV-2 on the insulin/IGF signaling pathway.

6 Jul 2022

Targeting C5a/C5aR1 signaling ameliorates COVID-19 immunopathology

A new study investigated the role of complement component 5a (C5a) and its receptor (C5a receptor type 1, C5aR1) in the pathophysiology of COVID-19.

6 Jul 2022

Study opens up a new avenue for the development of selective drug therapies

Researchers at the Department of Energy's Oak Ridge National Laboratory have definitively linked the function of a specific domain of proteins important in plant-microbe biology to a cancer trigger in humans, knowledge that had eluded scientists for decades.

5 Jul 2022

Novel oral nano-in-micro system provides efficient curcumin delivery to alleviate ulcerative colitis

A new study showed that the newly designed oral nano-in-micro hydrogel delivery platform could be efficiently used to deliver curcumin for the treatment of Ulcerative Colitis.

5 Jul 2022

Human gingival epithelial cells become damaged by cannabis smoke condensate

In a new study, scientists evaluated the effect of cannabis smoke condensate (CSC) on the gingival epithelial cells.

5 Jul 2022

Roundworms shed light on vision loss in a rare human genetic disorder

In this interview, News-Medical speaks to Xinxing Zhang, a postdoctoral research fellow at the University of Michigan, about his research investigating vision loss in Bardet-Biedl syndrome.

4 Jul 2022

Complex molecular dance could inform the development of future treatments for fragile X syndrome

Like many neurological diseases, there's a lot we don't understand about fragile X syndrome. But, after studying the disorder for several years, Lynne Maquat's lab knew two important things: the enzyme AKT, which plays a key role in cell growth and survival, and the quality control pathway known as NMD (nonsense-mediated mRNA decay), are both in overdrive in fragile X.

29 Jun 2022

COVID-19 can cause metabolism problems by interfering with insulin signaling, study reveals

It has become abundantly clear that coronavirus disease 19 (COVID-19), despite being transmitted by breathing in the SARS-CoV-2 virus, can have harmful effects far beyond the lungs.

27 Jun 2022

Scientists evaluate JNK inhibitors in treating moderate to severe COVID-19 patients

Scientists have described the clinical outcomes in hospitalized COVID-19 patients who have been treated with JNK inhibitors together with standard of care.

22 Jun 2022

Study offers new insight into the growth of blood vessels

Blood vessels must adapt their growth to the nutrients available in their surroundings so that they can keep organs adequately supplied. A team led by Michael Potente has identified two proteins that are important for this process and published their findings in Nature Metabolism.

20 Jun 2022

Researchers highlight the impact of macrophage subtypes on acute kidney injury to CKD transition

Acute kidney injury (AKI) is a condition in which kidneys are unable to filter waste from the blood effectively, leading to various health complications.

20 Jun 2022

New combination of drugs effective against T-cell acute lymphoblastic leukemia

Acute lymphoblastic leukemia (ALL) is the most common cancer affecting children. The T-ALL form of leukemia that emerges from early T lineage cells has a poorer prognosis than B-lineage ALL. The prognosis for relapsed T-ALL is very poor and new therapies are sorely needed.

20 Jun 2022

New research helps to better understand the basic biology of nerve cells

Scientists are starting to understand the precise workings of a type of gene that, unlike other genes, does not code for proteins – the building blocks of life.

16 Jun 2022

AKT inhibitor miransertib could be a promising new treatment against low-flow vascular malformations

A team of researchers led by Dr. Sandra Castillo and Dr. Mariona Graupera, from the Josep Carreras Leukaemia Research Institute and member of the CIBERONC, have found the AKT inhibitor miransertib could be a new molecular treatment effective against low-flow vascular malformations, a long-awaited milestone.

14 Jun 2022

Signaling Pathway News and Research

Researchers discover cell signaling pathway responsible for the development of esophageal cancers

Hollings researcher awarded grant to continue research into mechanisms behind medulloblastoma relapse

Discovery about how a certain protein is activated in tumor cells could lead to better treatments

Exploring the connection between Parkinson's disease and gut microbiota to uncover potential therapeutic targets

Study reveals a new molecular perspective to the cause of Gaucher's disease

Scientists identify molecules promoting plant immunity

COVID-19 impairs the insulin/IGF signaling pathway

Targeting C5a/C5aR1 signaling ameliorates COVID-19 immunopathology

Study opens up a new avenue for the development of selective drug therapies

Novel oral nano-in-micro system provides efficient curcumin delivery to alleviate ulcerative colitis

Human gingival epithelial cells become damaged by cannabis smoke condensate

Roundworms shed light on vision loss in a rare human genetic disorder

Complex molecular dance could inform the development of future treatments for fragile X syndrome

COVID-19 can cause metabolism problems by interfering with insulin signaling, study reveals

Scientists evaluate JNK inhibitors in treating moderate to severe COVID-19 patients

Study offers new insight into the growth of blood vessels

Researchers highlight the impact of macrophage subtypes on acute kidney injury to CKD transition

New combination of drugs effective against T-cell acute lymphoblastic leukemia

New research helps to better understand the basic biology of nerve cells

AKT inhibitor miransertib could be a promising new treatment against low-flow vascular malformations

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