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Researchers reveal immune machinery that goes awry to trigger neutrophilic dermatosis

A research team led by St. Jude Children's Research Hospital immunologists has revealed a previously unknown immune machinery that goes awry to trigger the inflammatory disease neutrophilic dermatosis.

18 Apr 2017

UC Riverside professor receives grant to explore therapeutic target for treating IBD patients

Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the intestine that includes Crohn's disease and ulcerative colitis. A protective protein that plays a key role in this disease is "T-cell protein tyrosine phosphatase" or TCPTP.

7 Apr 2017

Researchers report discovery of new gene linked to Tau accumulation in AD

Tau pathology is one of the defining features of Alzheimer disease (AD), which is the most common form of dementia in older age.

25 Mar 2017

New gene linked to Tau pathology

Investigators at Rush University Medical Center and the Brigham and Women's Hospital in Boston reported the discovery of a new gene that is associated with susceptibility to a common form of brain pathology called Tau that accumulates in several different conditions, including Alzheimer's disease, certain forms of dementia and Parkinsonian syndromes as well as chronic traumatic encephalopathy that occurs with repeated head injuries.

24 Mar 2017

Study identifies potential Achilles heel of kinase-driven cancers

Scientists identify two signaling proteins in cancer cells that make them resistant to chemotherapy, and show that blocking the proteins along with chemotherapy eliminate human leukemia in mouse models.

22 Mar 2017

Penn studies provide new understanding of lung cancer progression and prevention

Treating the brain with a preventative course of radiation may help Small Cell Lung Cancer (SCLC) patients - whose tumors often spread to their brain -- live longer, according to a new study from researchers in the Abramson Cancer Center and Perelman School of Medicine at the University of Pennsylvania.

16 Mar 2017

Researchers identify underlying cause of obsessive-compulsive disorder

An overactive molecular signal pathway in the brain region of the amygdala can lead to obsessive-compulsive disorder (OCD). A research team from Würzburg has established this connection.

16 Mar 2017

Drug could activate innate anti-tumor immunity to eradicate aggressive prostate cancer in mice

Cabozantinib, a drug already used to treat patients with certain types of thyroid or kidney cancer, was able to eradicate invasive prostate cancers in mice by causing tumor cells to secrete factors that entice neutrophils - the first-responders of the immune system - to infiltrate the tumor, where they triggered an immune response that led to tumor clearance.

9 Mar 2017

GUMC launches phase II clinical study to examine safety of cancer drug for Parkinson's disease

Georgetown University Medical Center today announces the launch of a phase II clinical trial to study the safety of the cancer drug nilotinib and its effects on clinical outcomes and biomarkers in people with Parkinson's disease.

27 Feb 2017

Research may show new ways to repress inflammation at outset

Researchers at the University of Tübingen, working with colleagues in other parts of Germany and in the United States, have identified an enzyme as a kind of biological gauge regulating inflammation in the human body.

21 Feb 2017

Researchers show how metabolism drives proliferation of tumor cells

The metabolic state of tumor cells contributes to signals that control the proliferation of tumor cells. Already the German biochemist and Nobel Prize laureate Otto H. Warburg observed in the 1920s that tumor cells radically change their metabolism.

20 Feb 2017

Researchers aim to recreate ‘tick cement’ as potential bioadhesive for human tissues

Ticks are well known for their ability to anchor themselves firmly to the skin, so that they can suck blood for several days.

20 Feb 2017

Study identifies protein in tumor microenvironment that promotes breast cancer spread

To understand what makes breast cancer spread, researchers are looking at where it lives - not just its original home in the breast but its new home where it settles in other organs. What's happening in that metastatic niche where migrated cancer cells are growing?

16 Feb 2017

Salk professor receives inaugural Sjöberg Prize for groundbreaking cancer research

Salk Professor Tony Hunter, who holds an American Cancer Society Professorship, has been awarded $500,000 as part of the $1 million Royal Swedish Academy of Sciences' inaugural Sjöberg Prize for Cancer Research for "groundbreaking studies of cellular processes that have led to the development of new and effective cancer drugs."

14 Feb 2017

Scientists discover new way to inhibit growth of glioblastoma

Scientists have found a way to inhibit the growth of glioblastoma, a type of brain cancer with low survival rates, by targeting a protein that drives growth of brain tumors, according to research from the Peter O'Donnell Jr. Brain Institute and Harold C. Simmons Comprehensive Cancer Center.

25 Jan 2017

KIT researchers prove that neurons regulate blood vessel growth

A team of researchers at Karlsruhe Institute of Technology shake at the foundations of a dogma of cell biology.

10 Jan 2017

The 10th annual symposium at UC Riverside focuses on glial-neuronal interactions in health and disease

The brain is home to two kinds of cells: neurons and glia, with the latter protecting the former. Glia, the stuff between neurons, are important also because they regulate and define neuron-neuron communication.

9 Jan 2017

Researchers pinpoint mechanism underlying astrocyte-mediated recovery of brain tissue after injury

A Kobe University research team has pinpointed the mechanism underlying astrocyte-mediated restoration of brain tissue after an injury. This could lead to new treatments that encourage regeneration by limiting damage to neurons incurred by reduced blood supply or trauma.

15 Dec 2016

Leukaemia patients could safely reduce side effects of drug by cutting dose in half, study shows

Patients with a chronic type of leukaemia could safely reduce the side effects of life-long treatment by cutting their dose in half, according to the results of a University of Liverpool led study presented at an international conference in America this week.

6 Dec 2016

New treatment with therapeutic short interfering RNA could help thwart cancer

In the fight against cancer, doctors dish out combination-blows of surgery, chemotherapy and other drugs to beat back a merciless foe. Now, scientists have taken early steps toward adding a stinging punch to clinicians' repertoire.

7 Nov 2016