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Researchers improve the system for stratifying mortality risk of variceal bleeding

Approximately half of patients with advanced liver disease have varicose veins in the esophagus and stomach, and a more than a fifth of them experience bleeding from these varices into the digestive tract.

13 Nov 2023

CRISPR-based gene-editing therapy could offer hope for people with inherited high LDL cholesterol

A single infusion of a CRISPR-based gene-editing therapy significantly reduced low-density lipoprotein cholesterol (LDL, the "bad cholesterol") in people who carry one gene for the inherited condition that results in very high LDL cholesterol levels and a high risk of heart attack at an early age, according to late-breaking science presented today at the American Heart Association's Scientific Sessions 2023.

13 Nov 2023

Exploring the use of psychedelics as novel treatments for psychiatric disorders

Psychedelic compounds such as psilocybin, a substance found in various mushroom species, are garnering more research support as novel treatments for psychiatric disorders, but questions remain concerning who they may help the most.

13 Nov 2023

Next-generation ovarian cancer therapy: Engineered Vδ2 T cells show promise in preclinical trials

A prospective path for allogeneic cellular immunotherapies.

13 Nov 2023

Revolutionizing critical care: the potential of gut microbiota therapeutics

The curative potential and limitations of gut microbiome-based therapeutics in critical illnesses.

13 Nov 2023

AdvanCell reaches milestone as first prostate cancer patient dosed with 212Pb-ADVC001

AdvanCell, a radiopharmaceutical company developing a pipeline of Targeted Alpha Therapies for cancer patients, today announced the first patient was treated with 212Pb-ADVC001, a Targeted Alpha Therapy in development for the treatment of PSMA-positive metastatic Castration-Resistant Prostate Cancer (mCRPC).

13 Nov 2023

UCI researchers discover gene critical for muscle repair

University of California, Irvine researchers have identified a gene expressed during regeneration that is critical for muscle repair.

12 Nov 2023

Gene therapy's double-edged sword: Breakthrough treatments face manufacturing and efficacy

Research explores the advancements, challenges, and economic implications of gene therapy for various diseases, including inherited blood disorders, malignancies treated with CAR-T cells, and diseases targeted by in vivo AAV vectors. The review highlights the transformative potential of gene therapies while acknowledging the complexities in manufacturing, safety, efficacy, and long-term durability.

12 Nov 2023

Heart attack patients without traditional risk factors have high levels of coronary calcium, study finds

While high cholesterol, high blood pressure, diabetes and smoking are well known heart disease risks, not everyone who has a heart attack has them.

11 Nov 2023

Preclinical research points to a promising new treatment option for pancreatic cancer patients

Preclinical research published in the Journal for ImmunoTherapy of Cancer points to a promising new treatment option for people with pancreatic cancer.

10 Nov 2023

RA patients in remission should continue TNF inhibitors to avoid flares, study finds

New research at ACR Convergence 2023, the American College of Rheumatology's (ACR) annual meeting, found that rheumatoid arthritis (RA) patients in sustained remission who stopped TNF inhibitors (TNFi) had significantly more flares and lower Boolean 2.0 remission rates compared with those who continued treatment.

10 Nov 2023

Autologous stem cell transplant shows promise for young patients with severe juvenile systemic sclerosis

New research at ACR Convergence 2023, the American College of Rheumatology's (ACR) annual meeting, shows that patients with refractory juvenile systemic sclerosis improved significantly on nearly all measures for two years following autologous stem cell transplant.

10 Nov 2023

New study sheds light on the genes and nutrients that give MAIT cells their fighting power

Scientists at La Jolla Institute for Immunology (LJI) are investigating a talented type of T cell.

10 Nov 2023

Clinical trial underway for novel human milk-based microbiome therapy

In a breakthrough for human milk science, researchers at City of Hope, Los Angeles, have dosed the first patient in a Phase 2a clinical trial evaluating a novel therapy for blood cancer patients undergoing allogeneic hematopoietic stem cell transplantation.

10 Nov 2023

Obinutuzumab shows promise in preserving kidney function, preventing flares in lupus nephritis patients

In a post hoc analysis of the phase 2 NOBILITY trial, researchers found that treatment with obinutuzumab - an antibody that targets a protein expressed on certain immune cells - was superior to placebo for preserving kidney function and preventing flares in patients with lupus nephritis, a kidney condition associated with the autoimmune disease lupus.

10 Nov 2023

Diverse gut bacteria could help fight cryptosporidiosis

The severity of a diarrheal disease could be down to the bacteria in your gut - according to new research from the University of East Anglia.

10 Nov 2023

Data, Design, and Discovery: Andrew Buchanan's Impact on Biologics Innovation

Andrew Buchanan on the Future of Biologics and AI

10 Nov 2023

SDF-4 protein shows promise for early detection of gastric cancer

A research team led by the Nagoya University Graduate School of Medicine has discovered that the stromal cell-derived factor 4 (SDF-4) protein is a reliable cancer marker.

9 Nov 2023

Preclinical discovery could point the way toward better treatments for type 2 diabetes

A drug currently in clinical trials as a cancer therapy can also stimulate pancreatic beta cells to secrete insulin, revealing a previously unknown mechanism for insulin regulation in type 2 diabetes, according to a new study by Weill Cornell Medicine investigators.

9 Nov 2023

Tumor-immune interactions predict treatment responses in multiple myeloma

A multicenter study led by researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine shows how interactions between tumor cells and immune components of the microenvironment can impact treatment responses and outcomes in patients newly diagnosed with multiple myeloma who undergo combination treatments that include targeted immunotherapy.

9 Nov 2023

Therapy News and Research

Researchers improve the system for stratifying mortality risk of variceal bleeding

CRISPR-based gene-editing therapy could offer hope for people with inherited high LDL cholesterol

Exploring the use of psychedelics as novel treatments for psychiatric disorders

Next-generation ovarian cancer therapy: Engineered Vδ2 T cells show promise in preclinical trials

Revolutionizing critical care: the potential of gut microbiota therapeutics

AdvanCell reaches milestone as first prostate cancer patient dosed with 212Pb-ADVC001

UCI researchers discover gene critical for muscle repair

Gene therapy's double-edged sword: Breakthrough treatments face manufacturing and efficacy

Heart attack patients without traditional risk factors have high levels of coronary calcium, study finds

Preclinical research points to a promising new treatment option for pancreatic cancer patients

RA patients in remission should continue TNF inhibitors to avoid flares, study finds

Autologous stem cell transplant shows promise for young patients with severe juvenile systemic sclerosis

New study sheds light on the genes and nutrients that give MAIT cells their fighting power

Clinical trial underway for novel human milk-based microbiome therapy

Obinutuzumab shows promise in preserving kidney function, preventing flares in lupus nephritis patients

Diverse gut bacteria could help fight cryptosporidiosis

Data, Design, and Discovery: Andrew Buchanan's Impact on Biologics Innovation

SDF-4 protein shows promise for early detection of gastric cancer

Preclinical discovery could point the way toward better treatments for type 2 diabetes

Tumor-immune interactions predict treatment responses in multiple myeloma

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

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