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BU researchers receive NIH grant to identify genetic factors for Alzheimer's disease

The National Institutes of Health/National Institute on Aging recently awarded a $13.7 million grant to a project led by Boston University Chobanian & Avedisian School of Medicine principal investigators Lindsay Farrer, PhD, chief of biomedical genetics and distinguished professor of genetics, and Richard Sherva, PhD, assistant professor of medicine in biomedical genetics, for research using whole genome sequencing and other approaches to identify genetic factors for Alzheimer disease (AD) in Jews currently living in Israel who trace their ancestors to southern Spain and locations in the Middle East and North Africa (MENA) and Arab citizens of Israel.

15 Sep 2023

NICER: A safer alternative to CRISPR/Cas9 for gene editing

The gene editing technique CRISPR/Cas9 has allowed researchers to make precise and impactful changes to an organism's DNA to fix mutations that cause genetic disease.

15 Sep 2023

A comprehensive analysis of first monkeypox outbreak in Shenzhen, China

This paper comprehensively analyses the first-ever monkeypox outbreak in Shenzhen, China encompassing clinical symptomatology, therapeutic approaches, epidemiological research, and comprehensive laboratory tests, aiming to establish a robust reference for future mitigation and management strategies for monkeypox.

15 Sep 2023

How does Helicobacter pylori infection influence rheumatoid arthritis?

The association between Helicobacter pylori infection and rheumatoid arthritis (RA).

15 Sep 2023

New genetic test reveals a person’s predisposition to happiness

Your happiness levels aren't only based on external events. Genome testing can reveal how happy and optimistic you are predisposed to be. A leading testing expert reveals how variations of a key gene, CNR1, may have a significant impact on your level of happiness.

15 Sep 2023

What drives the willingness to quit cigarette or snus use among young males?

The factors that enhance the willingness of young males to quit snus and cigarette smoking.

15 Sep 2023

Comparative genomic analysis between systemic juvenile rheumatoid arthritis and type 1 diabetes

Shared genetic markers and immune system involvement in sJRA and T1D.

15 Sep 2023

How does the APOE4 gene play both hero and villain in your health risks?

The study reveals that APOE4, a genetic risk factor for Alzheimer's Disease and cardiovascular diseases, has complex effects on mortality risk. While APOE4 carriers with higher AD neuropathology have increased mortality risk, those with low neuropathology had a reduced risk of certain cancers, warranting further research into this genetic factor's diverse impact on health outcomes.

14 Sep 2023

Genetic sequencing shows promise as first-tier newborn screening test

Newborn screening (NBS) is routinely performed across the world using biochemical testing methods. Recent advancements in genetic sequencing are a potential game-changer for newborn screening, swiftly assessing a comprehensive range of monogenic disorders.

14 Sep 2023

JAX offers a fully validated, clinical whole genome sequencing test

Until quite recently, it was extremely difficult to detect the variants underlying many genetic disorders. In the absence of a defined cause, clinicians have little to guide treatment for those left without a genetic diagnosis, forcing patients and families to embark on a diagnostic odyssey with no guarantee of finding answers.

14 Sep 2023

Study reveals how a causal factor in Angelman syndrome eliminates neural chat

Researchers from the University of Tokyo reveal how the presynaptic Ube3a E3 ligase, a causal factor in Angelman syndrome, eliminates neural chat.

14 Sep 2023

MIT study reveals why immunotherapy doesn't work for all cancer patients

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14 Sep 2023

NYU Langone doctors complete longest-documented case of pig kidney transplant in human body

After 61 days of observation, NYU Langone Health doctors this month completed the longest-documented case of a genetically engineered pig kidney functioning in a human body.

14 Sep 2023

Reviving reservoirs: new findings shake up HIV treatment understanding

Researchers provide insight into the interaction between T lymphocytes and persisting reservoirs of HIV, with repercussions for harnessing effective, long-lasting responses to HIV eradication.

14 Sep 2023

MRI innovation to unveil iron homeostasis in the human brain

Researchers demonstrated a MRI method sensitive to the live brain's iron homeostasis (the r1-r2 extent of relaxation or relaxivity).

14 Sep 2023

COVID-19 doubles risk of early type 1 diabetes signs in high-risk children

New research in JAMA finds a temporal association between SARS-CoV-2 infections and the onset of islet autoimmunity, a precursor to type 1 diabetes, in genetically predisposed infants. The study underscores COVID-19 as a potential risk factor for the development of this form of diabetes in young children.

13 Sep 2023